Effector functions of pathogenic Yersinia species.
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Effector functions of pathogenic Yersinia species. / Aepfelbacher, Martin; Trasak, Claudia; Ruckdeschel, Klaus.
In: THROMB HAEMOSTASIS, Vol. 98, No. 3, 3, 2007, p. 521-529.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Effector functions of pathogenic Yersinia species.
AU - Aepfelbacher, Martin
AU - Trasak, Claudia
AU - Ruckdeschel, Klaus
PY - 2007
Y1 - 2007
N2 - Pathogenic species of the genus Yersinia suppress and reorient the immune system to infect lymphatic tissues, inner organs and at times also the vasculature. For this purpose yersiniae employ a type III secretion system to translocate effector proteins (Yersinia outer proteins; Yops) into immune cells. Yops often exert unique biochemical activities for modulating the activity of Rho GTP-binding proteins, focal adhesion proteins, inflammatory pathways and cell survival/apoptosis. In this review we will put emphasis on the biochemistry, cell- and infection biology of Yersinia effector Yops.
AB - Pathogenic species of the genus Yersinia suppress and reorient the immune system to infect lymphatic tissues, inner organs and at times also the vasculature. For this purpose yersiniae employ a type III secretion system to translocate effector proteins (Yersinia outer proteins; Yops) into immune cells. Yops often exert unique biochemical activities for modulating the activity of Rho GTP-binding proteins, focal adhesion proteins, inflammatory pathways and cell survival/apoptosis. In this review we will put emphasis on the biochemistry, cell- and infection biology of Yersinia effector Yops.
M3 - SCORING: Zeitschriftenaufsatz
VL - 98
SP - 521
EP - 529
JO - THROMB HAEMOSTASIS
JF - THROMB HAEMOSTASIS
SN - 0340-6245
IS - 3
M1 - 3
ER -