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Effect of marathon and ultra-marathon on inflammation and iron homeostasis

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Effect of marathon and ultra-marathon on inflammation and iron homeostasis. / Kaufmann, Christoph C; Wegberger, Claudia; Tscharre, Maximilian; Haller, Paul M; Piackova, Edita; Vujasin, Irena; Kassem, Mona; Tentzeris, Ioannis; Freynhofer, Matthias K; Jäger, Bernhard; Wojta, Johann; Huber, Kurt.

In: SCAND J MED SCI SPOR, Vol. 31, No. 3, 03.2021, p. 542-552.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kaufmann, CC, Wegberger, C, Tscharre, M, Haller, PM, Piackova, E, Vujasin, I, Kassem, M, Tentzeris, I, Freynhofer, MK, Jäger, B, Wojta, J & Huber, K 2021, 'Effect of marathon and ultra-marathon on inflammation and iron homeostasis', SCAND J MED SCI SPOR, vol. 31, no. 3, pp. 542-552. https://doi.org/10.1111/sms.13869

APA

Kaufmann, C. C., Wegberger, C., Tscharre, M., Haller, P. M., Piackova, E., Vujasin, I., Kassem, M., Tentzeris, I., Freynhofer, M. K., Jäger, B., Wojta, J., & Huber, K. (2021). Effect of marathon and ultra-marathon on inflammation and iron homeostasis. SCAND J MED SCI SPOR, 31(3), 542-552. https://doi.org/10.1111/sms.13869

Vancouver

Kaufmann CC, Wegberger C, Tscharre M, Haller PM, Piackova E, Vujasin I et al. Effect of marathon and ultra-marathon on inflammation and iron homeostasis. SCAND J MED SCI SPOR. 2021 Mar;31(3):542-552. https://doi.org/10.1111/sms.13869

Bibtex

@article{1f65753842164a509dbae0fbd16befe8,
title = "Effect of marathon and ultra-marathon on inflammation and iron homeostasis",
abstract = "The physiological response to high-level endurance exercise, such as running a marathon, poses several beneficial but also potentially harmful metabolic changes. The objective of this study was to determine the impact of marathon (M) and ultra-marathon (UM) on inflammation and iron homeostasis in paired samples. Fifteen well-trained, non-professional endurance athletes (14 males, 1 female) performed both a 130 km ultra-marathon and a traditional 42.195 km marathon. We determined markers of inflammation and iron homeostasis before, immediately after, and within 5 days after finishing each run, respectively. Biomarkers of inflammation (leucocytes, neutrophil granulocytes, monocytes, and c-reactive protein [CRP]) increased significantly after both marathon and ultra-marathon with higher levels of CRP after ultra-marathon compared with marathon both immediately after the race (18.15 ± 12.41 vs 5.58 ± 9.65 mg/L, P < .001) and at follow-up (15.67 ± 16.97 vs 7.19 ± 7.75 mg/L, P = .045) Concentrations of ferritin also increased significantly after both races and remained high at follow-up. Higher levels of ferritin immediately after the race (111.5 ± 103.2 vs 84.8 ± 86.3, P = .001) and at follow-up (102.7 ± 79.5 vs 74.6 ± 65.6, P = .001) were found in ultra-marathon finishers. The observed increase of serum iron and transferrin saturation (TSAT) after marathon and the decrease of serum iron and TSAT after ultra-marathon resulted in a significant absolute difference between the two races. The present data suggest a higher degree of inflammation after ultra-marathon compared with marathon. Markers of iron homeostasis also showed different response patterns with regard to running distance.",
keywords = "Adult, Biomarkers/blood, C-Reactive Protein/metabolism, Energy Metabolism, Female, Ferritins/blood, Homeostasis, Humans, Inflammation/blood, Iron/blood, Leukocytes/metabolism, Male, Marathon Running/physiology, Monocytes/metabolism, Muscle, Skeletal/injuries, Neutrophils/metabolism, Prospective Studies",
author = "Kaufmann, {Christoph C} and Claudia Wegberger and Maximilian Tscharre and Haller, {Paul M} and Edita Piackova and Irena Vujasin and Mona Kassem and Ioannis Tentzeris and Freynhofer, {Matthias K} and Bernhard J{\"a}ger and Johann Wojta and Kurt Huber",
note = "{\textcopyright} 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.",
year = "2021",
month = mar,
doi = "10.1111/sms.13869",
language = "English",
volume = "31",
pages = "542--552",
journal = "SCAND J MED SCI SPOR",
issn = "0905-7188",
publisher = "Blackwell Munksgaard",
number = "3",

}

RIS

TY - JOUR

T1 - Effect of marathon and ultra-marathon on inflammation and iron homeostasis

AU - Kaufmann, Christoph C

AU - Wegberger, Claudia

AU - Tscharre, Maximilian

AU - Haller, Paul M

AU - Piackova, Edita

AU - Vujasin, Irena

AU - Kassem, Mona

AU - Tentzeris, Ioannis

AU - Freynhofer, Matthias K

AU - Jäger, Bernhard

AU - Wojta, Johann

AU - Huber, Kurt

N1 - © 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

PY - 2021/3

Y1 - 2021/3

N2 - The physiological response to high-level endurance exercise, such as running a marathon, poses several beneficial but also potentially harmful metabolic changes. The objective of this study was to determine the impact of marathon (M) and ultra-marathon (UM) on inflammation and iron homeostasis in paired samples. Fifteen well-trained, non-professional endurance athletes (14 males, 1 female) performed both a 130 km ultra-marathon and a traditional 42.195 km marathon. We determined markers of inflammation and iron homeostasis before, immediately after, and within 5 days after finishing each run, respectively. Biomarkers of inflammation (leucocytes, neutrophil granulocytes, monocytes, and c-reactive protein [CRP]) increased significantly after both marathon and ultra-marathon with higher levels of CRP after ultra-marathon compared with marathon both immediately after the race (18.15 ± 12.41 vs 5.58 ± 9.65 mg/L, P < .001) and at follow-up (15.67 ± 16.97 vs 7.19 ± 7.75 mg/L, P = .045) Concentrations of ferritin also increased significantly after both races and remained high at follow-up. Higher levels of ferritin immediately after the race (111.5 ± 103.2 vs 84.8 ± 86.3, P = .001) and at follow-up (102.7 ± 79.5 vs 74.6 ± 65.6, P = .001) were found in ultra-marathon finishers. The observed increase of serum iron and transferrin saturation (TSAT) after marathon and the decrease of serum iron and TSAT after ultra-marathon resulted in a significant absolute difference between the two races. The present data suggest a higher degree of inflammation after ultra-marathon compared with marathon. Markers of iron homeostasis also showed different response patterns with regard to running distance.

AB - The physiological response to high-level endurance exercise, such as running a marathon, poses several beneficial but also potentially harmful metabolic changes. The objective of this study was to determine the impact of marathon (M) and ultra-marathon (UM) on inflammation and iron homeostasis in paired samples. Fifteen well-trained, non-professional endurance athletes (14 males, 1 female) performed both a 130 km ultra-marathon and a traditional 42.195 km marathon. We determined markers of inflammation and iron homeostasis before, immediately after, and within 5 days after finishing each run, respectively. Biomarkers of inflammation (leucocytes, neutrophil granulocytes, monocytes, and c-reactive protein [CRP]) increased significantly after both marathon and ultra-marathon with higher levels of CRP after ultra-marathon compared with marathon both immediately after the race (18.15 ± 12.41 vs 5.58 ± 9.65 mg/L, P < .001) and at follow-up (15.67 ± 16.97 vs 7.19 ± 7.75 mg/L, P = .045) Concentrations of ferritin also increased significantly after both races and remained high at follow-up. Higher levels of ferritin immediately after the race (111.5 ± 103.2 vs 84.8 ± 86.3, P = .001) and at follow-up (102.7 ± 79.5 vs 74.6 ± 65.6, P = .001) were found in ultra-marathon finishers. The observed increase of serum iron and transferrin saturation (TSAT) after marathon and the decrease of serum iron and TSAT after ultra-marathon resulted in a significant absolute difference between the two races. The present data suggest a higher degree of inflammation after ultra-marathon compared with marathon. Markers of iron homeostasis also showed different response patterns with regard to running distance.

KW - Adult

KW - Biomarkers/blood

KW - C-Reactive Protein/metabolism

KW - Energy Metabolism

KW - Female

KW - Ferritins/blood

KW - Homeostasis

KW - Humans

KW - Inflammation/blood

KW - Iron/blood

KW - Leukocytes/metabolism

KW - Male

KW - Marathon Running/physiology

KW - Monocytes/metabolism

KW - Muscle, Skeletal/injuries

KW - Neutrophils/metabolism

KW - Prospective Studies

U2 - 10.1111/sms.13869

DO - 10.1111/sms.13869

M3 - SCORING: Journal article

C2 - 33140866

VL - 31

SP - 542

EP - 552

JO - SCAND J MED SCI SPOR

JF - SCAND J MED SCI SPOR

SN - 0905-7188

IS - 3

ER -