Effect of marathon and ultra-marathon on inflammation and iron homeostasis
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Effect of marathon and ultra-marathon on inflammation and iron homeostasis. / Kaufmann, Christoph C; Wegberger, Claudia; Tscharre, Maximilian; Haller, Paul M; Piackova, Edita; Vujasin, Irena; Kassem, Mona; Tentzeris, Ioannis; Freynhofer, Matthias K; Jäger, Bernhard; Wojta, Johann; Huber, Kurt.
in: SCAND J MED SCI SPOR, Jahrgang 31, Nr. 3, 03.2021, S. 542-552.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Effect of marathon and ultra-marathon on inflammation and iron homeostasis
AU - Kaufmann, Christoph C
AU - Wegberger, Claudia
AU - Tscharre, Maximilian
AU - Haller, Paul M
AU - Piackova, Edita
AU - Vujasin, Irena
AU - Kassem, Mona
AU - Tentzeris, Ioannis
AU - Freynhofer, Matthias K
AU - Jäger, Bernhard
AU - Wojta, Johann
AU - Huber, Kurt
N1 - © 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
PY - 2021/3
Y1 - 2021/3
N2 - The physiological response to high-level endurance exercise, such as running a marathon, poses several beneficial but also potentially harmful metabolic changes. The objective of this study was to determine the impact of marathon (M) and ultra-marathon (UM) on inflammation and iron homeostasis in paired samples. Fifteen well-trained, non-professional endurance athletes (14 males, 1 female) performed both a 130 km ultra-marathon and a traditional 42.195 km marathon. We determined markers of inflammation and iron homeostasis before, immediately after, and within 5 days after finishing each run, respectively. Biomarkers of inflammation (leucocytes, neutrophil granulocytes, monocytes, and c-reactive protein [CRP]) increased significantly after both marathon and ultra-marathon with higher levels of CRP after ultra-marathon compared with marathon both immediately after the race (18.15 ± 12.41 vs 5.58 ± 9.65 mg/L, P < .001) and at follow-up (15.67 ± 16.97 vs 7.19 ± 7.75 mg/L, P = .045) Concentrations of ferritin also increased significantly after both races and remained high at follow-up. Higher levels of ferritin immediately after the race (111.5 ± 103.2 vs 84.8 ± 86.3, P = .001) and at follow-up (102.7 ± 79.5 vs 74.6 ± 65.6, P = .001) were found in ultra-marathon finishers. The observed increase of serum iron and transferrin saturation (TSAT) after marathon and the decrease of serum iron and TSAT after ultra-marathon resulted in a significant absolute difference between the two races. The present data suggest a higher degree of inflammation after ultra-marathon compared with marathon. Markers of iron homeostasis also showed different response patterns with regard to running distance.
AB - The physiological response to high-level endurance exercise, such as running a marathon, poses several beneficial but also potentially harmful metabolic changes. The objective of this study was to determine the impact of marathon (M) and ultra-marathon (UM) on inflammation and iron homeostasis in paired samples. Fifteen well-trained, non-professional endurance athletes (14 males, 1 female) performed both a 130 km ultra-marathon and a traditional 42.195 km marathon. We determined markers of inflammation and iron homeostasis before, immediately after, and within 5 days after finishing each run, respectively. Biomarkers of inflammation (leucocytes, neutrophil granulocytes, monocytes, and c-reactive protein [CRP]) increased significantly after both marathon and ultra-marathon with higher levels of CRP after ultra-marathon compared with marathon both immediately after the race (18.15 ± 12.41 vs 5.58 ± 9.65 mg/L, P < .001) and at follow-up (15.67 ± 16.97 vs 7.19 ± 7.75 mg/L, P = .045) Concentrations of ferritin also increased significantly after both races and remained high at follow-up. Higher levels of ferritin immediately after the race (111.5 ± 103.2 vs 84.8 ± 86.3, P = .001) and at follow-up (102.7 ± 79.5 vs 74.6 ± 65.6, P = .001) were found in ultra-marathon finishers. The observed increase of serum iron and transferrin saturation (TSAT) after marathon and the decrease of serum iron and TSAT after ultra-marathon resulted in a significant absolute difference between the two races. The present data suggest a higher degree of inflammation after ultra-marathon compared with marathon. Markers of iron homeostasis also showed different response patterns with regard to running distance.
KW - Adult
KW - Biomarkers/blood
KW - C-Reactive Protein/metabolism
KW - Energy Metabolism
KW - Female
KW - Ferritins/blood
KW - Homeostasis
KW - Humans
KW - Inflammation/blood
KW - Iron/blood
KW - Leukocytes/metabolism
KW - Male
KW - Marathon Running/physiology
KW - Monocytes/metabolism
KW - Muscle, Skeletal/injuries
KW - Neutrophils/metabolism
KW - Prospective Studies
U2 - 10.1111/sms.13869
DO - 10.1111/sms.13869
M3 - SCORING: Journal article
C2 - 33140866
VL - 31
SP - 542
EP - 552
JO - SCAND J MED SCI SPOR
JF - SCAND J MED SCI SPOR
SN - 0905-7188
IS - 3
ER -