Effect of empirical treatment with moxifloxacin and meropenem vs meropenem on sepsis-related organ dysfunction in patients with severe sepsis: a randomized trial.
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Effect of empirical treatment with moxifloxacin and meropenem vs meropenem on sepsis-related organ dysfunction in patients with severe sepsis: a randomized trial. / Brunkhorst, Frank M; Oppert, Michael; Marx, Gernot; Bloos, Frank; Ludewig, Katrin; Putensen, Christian; Nierhaus, Axel; Jaschinski, Ulrich; Meier-Hellmann, Andreas; Weyland, Andreas; Gründling, Matthias; Moerer, Onnen; Riessen, Reimer; Seibel, Armin; Ragaller, Maximilian; Büchler, Markus W; John, Stefan; Bach, Friedhelm; Spies, Claudia; Reill, Lorenz; Fritz, Harald; Kiehntopf, Michael; Kuhnt, Evelyn; Bogatsch, Holger; Engel, Christoph; Loeffler, Markus; Kollef, Marin H; Reinhart, Konrad; Welte, Tobias; Sepsis, German Study Group Competence Network.
In: JAMA-J AM MED ASSOC, Vol. 307, No. 22, 22, 2012, p. 2390-2399.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Effect of empirical treatment with moxifloxacin and meropenem vs meropenem on sepsis-related organ dysfunction in patients with severe sepsis: a randomized trial.
AU - Brunkhorst, Frank M
AU - Oppert, Michael
AU - Marx, Gernot
AU - Bloos, Frank
AU - Ludewig, Katrin
AU - Putensen, Christian
AU - Nierhaus, Axel
AU - Jaschinski, Ulrich
AU - Meier-Hellmann, Andreas
AU - Weyland, Andreas
AU - Gründling, Matthias
AU - Moerer, Onnen
AU - Riessen, Reimer
AU - Seibel, Armin
AU - Ragaller, Maximilian
AU - Büchler, Markus W
AU - John, Stefan
AU - Bach, Friedhelm
AU - Spies, Claudia
AU - Reill, Lorenz
AU - Fritz, Harald
AU - Kiehntopf, Michael
AU - Kuhnt, Evelyn
AU - Bogatsch, Holger
AU - Engel, Christoph
AU - Loeffler, Markus
AU - Kollef, Marin H
AU - Reinhart, Konrad
AU - Welte, Tobias
AU - Sepsis, German Study Group Competence Network
PY - 2012
Y1 - 2012
N2 - Early appropriate antimicrobial therapy leads to lower mortality rates associated with severe sepsis. The role of empirical combination therapy comprising at least 2 antibiotics of different mechanisms remains controversial.
AB - Early appropriate antimicrobial therapy leads to lower mortality rates associated with severe sepsis. The role of empirical combination therapy comprising at least 2 antibiotics of different mechanisms remains controversial.
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Treatment Outcome
KW - Survival Analysis
KW - Drug Therapy, Combination
KW - Anti-Bacterial Agents/therapeutic use
KW - Aza Compounds/therapeutic use
KW - Multiple Organ Failure/etiology/prevention & control
KW - Quinolines/therapeutic use
KW - Sepsis/complications/drug therapy
KW - Shock, Septic/complications/drug therapy
KW - Thienamycins/therapeutic use
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Treatment Outcome
KW - Survival Analysis
KW - Drug Therapy, Combination
KW - Anti-Bacterial Agents/therapeutic use
KW - Aza Compounds/therapeutic use
KW - Multiple Organ Failure/etiology/prevention & control
KW - Quinolines/therapeutic use
KW - Sepsis/complications/drug therapy
KW - Shock, Septic/complications/drug therapy
KW - Thienamycins/therapeutic use
M3 - SCORING: Journal article
VL - 307
SP - 2390
EP - 2399
JO - JAMA-J AM MED ASSOC
JF - JAMA-J AM MED ASSOC
SN - 0098-7484
IS - 22
M1 - 22
ER -