Effect of empirical treatment with moxifloxacin and meropenem vs meropenem on sepsis-related organ dysfunction in patients with severe sepsis: a randomized trial.

  • Frank M Brunkhorst
  • Michael Oppert
  • Gernot Marx
  • Frank Bloos
  • Katrin Ludewig
  • Christian Putensen
  • Axel Nierhaus
  • Ulrich Jaschinski
  • Andreas Meier-Hellmann
  • Andreas Weyland
  • Matthias Gründling
  • Onnen Moerer
  • Reimer Riessen
  • Armin Seibel
  • Maximilian Ragaller
  • Markus W Büchler
  • Stefan John
  • Friedhelm Bach
  • Claudia Spies
  • Lorenz Reill
  • Harald Fritz
  • Michael Kiehntopf
  • Evelyn Kuhnt
  • Holger Bogatsch
  • Christoph Engel
  • Markus Loeffler
  • Marin H Kollef
  • Konrad Reinhart
  • Tobias Welte
  • German Study Group Competence Network Sepsis

Related Research units

Abstract

Early appropriate antimicrobial therapy leads to lower mortality rates associated with severe sepsis. The role of empirical combination therapy comprising at least 2 antibiotics of different mechanisms remains controversial.

Bibliographical data

Original languageEnglish
Article number22
ISSN0098-7484
Publication statusPublished - 2012
pubmed 22692171