EEG changes and serum anticholinergic activity measured in patients with delirium in the intensive care unit.
Standard
EEG changes and serum anticholinergic activity measured in patients with delirium in the intensive care unit. / Plaschke, K; Hill, H; Engelhardt, Ria; Thomas, C; von Haken, R; Scholz, M; Kopitz, J; Bardenheuer, H J; Weisbrod, M; Weigand, M A.
In: ANAESTHESIA, Vol. 62, No. 12, 12, 2007, p. 1217-1223.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - EEG changes and serum anticholinergic activity measured in patients with delirium in the intensive care unit.
AU - Plaschke, K
AU - Hill, H
AU - Engelhardt, Ria
AU - Thomas, C
AU - von Haken, R
AU - Scholz, M
AU - Kopitz, J
AU - Bardenheuer, H J
AU - Weisbrod, M
AU - Weigand, M A
PY - 2007
Y1 - 2007
N2 - The aim of this study was to examine whether serum anticholinergic activity (SAA) is a reliable indicator of delirium in the ICU, and whether there is a significant correlation between SAA and quantitative electroencephalographic (EEG) data in delirious patients. In a prospective cohort study, we assessed ICU patients diagnosed with delirium (n = 37). EEG measurements and blood analysis including SAA were performed 48 h following ICU admission. The presence of delirium was evaluated using the Confusion Assessment Method for critically ill patients in ICU (CAM-ICU). The SAA level was measured using a competitive radioreceptor binding assay for muscarinergic receptors and quantitative EEG was measured using the CATEEM system. We found that, under comparable conditions, patients in the delirium group showed a higher relative EEG theta power and a reduced alpha power (n = 17) than did the non-delirious patients (n = 20). No difference in measured SAA levels were seen; therefore, there was no correlation between SAA and EEG measurements in delirious patients. We conclude that, in contrast to the EEG, the SAA level cannot be proposed as a tool for diagnosing delirium in ICU patients.
AB - The aim of this study was to examine whether serum anticholinergic activity (SAA) is a reliable indicator of delirium in the ICU, and whether there is a significant correlation between SAA and quantitative electroencephalographic (EEG) data in delirious patients. In a prospective cohort study, we assessed ICU patients diagnosed with delirium (n = 37). EEG measurements and blood analysis including SAA were performed 48 h following ICU admission. The presence of delirium was evaluated using the Confusion Assessment Method for critically ill patients in ICU (CAM-ICU). The SAA level was measured using a competitive radioreceptor binding assay for muscarinergic receptors and quantitative EEG was measured using the CATEEM system. We found that, under comparable conditions, patients in the delirium group showed a higher relative EEG theta power and a reduced alpha power (n = 17) than did the non-delirious patients (n = 20). No difference in measured SAA levels were seen; therefore, there was no correlation between SAA and EEG measurements in delirious patients. We conclude that, in contrast to the EEG, the SAA level cannot be proposed as a tool for diagnosing delirium in ICU patients.
M3 - SCORING: Zeitschriftenaufsatz
VL - 62
SP - 1217
EP - 1223
JO - ANAESTHESIA
JF - ANAESTHESIA
SN - 0003-2409
IS - 12
M1 - 12
ER -
