EEG changes and serum anticholinergic activity measured in patients with delirium in the intensive care unit.
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EEG changes and serum anticholinergic activity measured in patients with delirium in the intensive care unit. / Plaschke, K; Hill, H; Engelhardt, Ria; Thomas, C; von Haken, R; Scholz, M; Kopitz, J; Bardenheuer, H J; Weisbrod, M; Weigand, M A.
in: ANAESTHESIA, Jahrgang 62, Nr. 12, 12, 2007, S. 1217-1223.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - EEG changes and serum anticholinergic activity measured in patients with delirium in the intensive care unit.
AU - Plaschke, K
AU - Hill, H
AU - Engelhardt, Ria
AU - Thomas, C
AU - von Haken, R
AU - Scholz, M
AU - Kopitz, J
AU - Bardenheuer, H J
AU - Weisbrod, M
AU - Weigand, M A
PY - 2007
Y1 - 2007
N2 - The aim of this study was to examine whether serum anticholinergic activity (SAA) is a reliable indicator of delirium in the ICU, and whether there is a significant correlation between SAA and quantitative electroencephalographic (EEG) data in delirious patients. In a prospective cohort study, we assessed ICU patients diagnosed with delirium (n = 37). EEG measurements and blood analysis including SAA were performed 48 h following ICU admission. The presence of delirium was evaluated using the Confusion Assessment Method for critically ill patients in ICU (CAM-ICU). The SAA level was measured using a competitive radioreceptor binding assay for muscarinergic receptors and quantitative EEG was measured using the CATEEM system. We found that, under comparable conditions, patients in the delirium group showed a higher relative EEG theta power and a reduced alpha power (n = 17) than did the non-delirious patients (n = 20). No difference in measured SAA levels were seen; therefore, there was no correlation between SAA and EEG measurements in delirious patients. We conclude that, in contrast to the EEG, the SAA level cannot be proposed as a tool for diagnosing delirium in ICU patients.
AB - The aim of this study was to examine whether serum anticholinergic activity (SAA) is a reliable indicator of delirium in the ICU, and whether there is a significant correlation between SAA and quantitative electroencephalographic (EEG) data in delirious patients. In a prospective cohort study, we assessed ICU patients diagnosed with delirium (n = 37). EEG measurements and blood analysis including SAA were performed 48 h following ICU admission. The presence of delirium was evaluated using the Confusion Assessment Method for critically ill patients in ICU (CAM-ICU). The SAA level was measured using a competitive radioreceptor binding assay for muscarinergic receptors and quantitative EEG was measured using the CATEEM system. We found that, under comparable conditions, patients in the delirium group showed a higher relative EEG theta power and a reduced alpha power (n = 17) than did the non-delirious patients (n = 20). No difference in measured SAA levels were seen; therefore, there was no correlation between SAA and EEG measurements in delirious patients. We conclude that, in contrast to the EEG, the SAA level cannot be proposed as a tool for diagnosing delirium in ICU patients.
M3 - SCORING: Zeitschriftenaufsatz
VL - 62
SP - 1217
EP - 1223
JO - ANAESTHESIA
JF - ANAESTHESIA
SN - 0003-2409
IS - 12
M1 - 12
ER -