Early detection and integrated care for adolescents and young adults with psychotic disorders. The ACCESS III study

M Lambert; D Schöttle; F Ruppelt; A Rohenkohl; M Sengutta; Daniel Lüdecke; L A  Nawara; Britta Galling; A-L Falk; L Wittmann; V Niehaus; G Sarikaya; L Rietschel; C Gagern; M Schulte-Markwort; Hans-Peter Unger; Sabine Ott; G Romer; A Daubmann; K Wegscheider; C U Correll; B G Schimmelmann; K Wiedemann; T Bock; J Gallinat; A Karow

doi:10.1111/acps.12762

Early detection and integrated care for adolescents and young adults with psychotic disorders. The ACCESS III study

Standard

Early detection and integrated care for adolescents and young adults with psychotic disorders. The ACCESS III study. / Lambert, M ; Schöttle, D; Ruppelt, F; Rohenkohl, A ; Sengutta, M ; Lüdecke, Daniel; Nawara, L A ; Galling, Britta; Falk, A-L; Wittmann, L; Niehaus, V; Sarikaya, G; Rietschel, L; Gagern, C; Schulte-Markwort, M; Unger, Hans-Peter; Ott, Sabine; Romer, G; Daubmann, A ; Wegscheider, K; Correll, C U; Schimmelmann, B G; Wiedemann, K; Bock, T ; Gallinat, J ; Karow, A.

In: ACTA PSYCHIAT SCAND, Vol. 136, No. 2, 08.2017, p. 188-200.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Lambert, M , Schöttle, D, Ruppelt, F, Rohenkohl, A , Sengutta, M , Lüdecke, D, Nawara, LA, Galling, B, Falk, A-L, Wittmann, L, Niehaus, V, Sarikaya, G, Rietschel, L, Gagern, C, Schulte-Markwort, M, Unger, H-P, Ott, S, Romer, G, Daubmann, A , Wegscheider, K, Correll, CU, Schimmelmann, BG, Wiedemann, K, Bock, T , Gallinat, J & Karow, A 2017, 'Early detection and integrated care for adolescents and young adults with psychotic disorders. The ACCESS III study', ACTA PSYCHIAT SCAND, vol. 136, no. 2, pp. 188-200. https://doi.org/10.1111/acps.12762

APA

Lambert, M., Schöttle, D., Ruppelt, F., Rohenkohl, A., Sengutta, M., Lüdecke, D., Nawara, L. A., Galling, B., Falk, A-L., Wittmann, L., Niehaus, V., Sarikaya, G., Rietschel, L., Gagern, C., Schulte-Markwort, M., Unger, H-P., Ott, S., Romer, G., Daubmann, A., ... Karow, A. (2017). Early detection and integrated care for adolescents and young adults with psychotic disorders. The ACCESS III study. ACTA PSYCHIAT SCAND, 136(2), 188-200. https://doi.org/10.1111/acps.12762

Vancouver

Lambert M , Schöttle D, Ruppelt F, Rohenkohl A , Sengutta M , Lüdecke D et al. Early detection and integrated care for adolescents and young adults with psychotic disorders. The ACCESS III study. ACTA PSYCHIAT SCAND. 2017 Aug;136(2):188-200. https://doi.org/10.1111/acps.12762

Bibtex

@article{d0372ff6e48f48ea8a2d812134c41d74,

title = "Early detection and integrated care for adolescents and young adults with psychotic disorders. The ACCESS III study",

abstract = "OBJECTIVE: The objective of the study was to investigate whether a combined intervention composed of early detection plus integrated care (EDIC) enhances outcomes in patients with early psychosis compared to standard care (SC).METHODS: ACCESS III is a prospective non-randomized historical control design 1-year study examining the efficacy of EDIC (n = 120) vs. SC (n = 105) in patients aged 12-29 years. Primary outcome was the rate of ≥6 months combined symptomatic and functional remission. Additional outcomes comprised the reduction of DUP and course of psychopathology, functioning, quality of life, and satisfaction with care.RESULTS: In observed cases, 48.9% in the EDIC and 15.2% in the SC group reached the primary endpoint. Remission was predicted by EDIC (OR = 6.8, CI: 3.15-14.53, P < 0.001); younger age predicted non-remission (OR = 1.1, CI: 1.01-1.19, P = 0.038). Linear regressions indicated a reduction of DUP in EDIC (P < 0.001), but not in SC (P = 0.41). MMRMs showed significantly larger improvements in PANSS positive (P < 0.001) and GAF (P < 0.01) scores in EDIC vs. SC, and in EDIC over time in CGI-Severity (P < 0.001) and numerically in Q-LES-Q-18 (P = 0.052).CONCLUSIONS: EDIC lead to significantly higher proportions of patients achieving combined remission. Moderating variables included a reduction of DUP and EDIC, offering psychotherapeutic interventions.",

keywords = "Journal Article",

author = "M Lambert and D Sch{\"o}ttle and F Ruppelt and A Rohenkohl and M Sengutta and Daniel L{\"u}decke and Nawara, {L A} and Britta Galling and A-L Falk and L Wittmann and V Niehaus and G Sarikaya and L Rietschel and C Gagern and M Schulte-Markwort and Hans-Peter Unger and Sabine Ott and G Romer and A Daubmann and K Wegscheider and Correll, {C U} and Schimmelmann, {B G} and K Wiedemann and T Bock and J Gallinat and A Karow",

note = "{\textcopyright} 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.",

year = "2017",

month = aug,

doi = "10.1111/acps.12762",

language = "English",

volume = "136",

pages = "188--200",

journal = "ACTA PSYCHIAT SCAND",

issn = "0001-690X",

publisher = "Wiley-Blackwell",

number = "2",

}

RIS

TY - JOUR

T1 - Early detection and integrated care for adolescents and young adults with psychotic disorders. The ACCESS III study

AU - Lambert, M

AU - Schöttle, D

AU - Ruppelt, F

AU - Rohenkohl, A

AU - Sengutta, M

AU - Lüdecke, Daniel

AU - Nawara, L A

AU - Galling, Britta

AU - Falk, A-L

AU - Wittmann, L

AU - Niehaus, V

AU - Sarikaya, G

AU - Rietschel, L

AU - Gagern, C

AU - Schulte-Markwort, M

AU - Unger, Hans-Peter

AU - Ott, Sabine

AU - Romer, G

AU - Daubmann, A

AU - Wegscheider, K

AU - Correll, C U

AU - Schimmelmann, B G

AU - Wiedemann, K

AU - Bock, T

AU - Gallinat, J

AU - Karow, A

PY - 2017/8

Y1 - 2017/8

N2 - OBJECTIVE: The objective of the study was to investigate whether a combined intervention composed of early detection plus integrated care (EDIC) enhances outcomes in patients with early psychosis compared to standard care (SC).METHODS: ACCESS III is a prospective non-randomized historical control design 1-year study examining the efficacy of EDIC (n = 120) vs. SC (n = 105) in patients aged 12-29 years. Primary outcome was the rate of ≥6 months combined symptomatic and functional remission. Additional outcomes comprised the reduction of DUP and course of psychopathology, functioning, quality of life, and satisfaction with care.RESULTS: In observed cases, 48.9% in the EDIC and 15.2% in the SC group reached the primary endpoint. Remission was predicted by EDIC (OR = 6.8, CI: 3.15-14.53, P < 0.001); younger age predicted non-remission (OR = 1.1, CI: 1.01-1.19, P = 0.038). Linear regressions indicated a reduction of DUP in EDIC (P < 0.001), but not in SC (P = 0.41). MMRMs showed significantly larger improvements in PANSS positive (P < 0.001) and GAF (P < 0.01) scores in EDIC vs. SC, and in EDIC over time in CGI-Severity (P < 0.001) and numerically in Q-LES-Q-18 (P = 0.052).CONCLUSIONS: EDIC lead to significantly higher proportions of patients achieving combined remission. Moderating variables included a reduction of DUP and EDIC, offering psychotherapeutic interventions.

AB - OBJECTIVE: The objective of the study was to investigate whether a combined intervention composed of early detection plus integrated care (EDIC) enhances outcomes in patients with early psychosis compared to standard care (SC).METHODS: ACCESS III is a prospective non-randomized historical control design 1-year study examining the efficacy of EDIC (n = 120) vs. SC (n = 105) in patients aged 12-29 years. Primary outcome was the rate of ≥6 months combined symptomatic and functional remission. Additional outcomes comprised the reduction of DUP and course of psychopathology, functioning, quality of life, and satisfaction with care.RESULTS: In observed cases, 48.9% in the EDIC and 15.2% in the SC group reached the primary endpoint. Remission was predicted by EDIC (OR = 6.8, CI: 3.15-14.53, P < 0.001); younger age predicted non-remission (OR = 1.1, CI: 1.01-1.19, P = 0.038). Linear regressions indicated a reduction of DUP in EDIC (P < 0.001), but not in SC (P = 0.41). MMRMs showed significantly larger improvements in PANSS positive (P < 0.001) and GAF (P < 0.01) scores in EDIC vs. SC, and in EDIC over time in CGI-Severity (P < 0.001) and numerically in Q-LES-Q-18 (P = 0.052).CONCLUSIONS: EDIC lead to significantly higher proportions of patients achieving combined remission. Moderating variables included a reduction of DUP and EDIC, offering psychotherapeutic interventions.

KW - Journal Article

U2 - 10.1111/acps.12762

DO - 10.1111/acps.12762

M3 - SCORING: Journal article

C2 - 28589683

VL - 136

SP - 188

EP - 200

JO - ACTA PSYCHIAT SCAND

JF - ACTA PSYCHIAT SCAND

SN - 0001-690X

IS - 2

ER -