Dying-back oligodendrogliopathy
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Dying-back oligodendrogliopathy : a late sequel of myelin-associated glycoprotein deficiency. / Lassmann, H; Bartsch, U; Montag, D; Schachner, M.
In: GLIA, Vol. 19, No. 2, 02.1997, p. 104-10.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Dying-back oligodendrogliopathy
T2 - a late sequel of myelin-associated glycoprotein deficiency
AU - Lassmann, H
AU - Bartsch, U
AU - Montag, D
AU - Schachner, M
PY - 1997/2
Y1 - 1997/2
N2 - Ultrastructural analysis of myelin from 8-month-old mice deficient in the myelin-associated glycoprotein revealed pronounced and characteristic alterations of the periaxonal oligodendrocyte processes, consisting of intracytoplasmic deposition of vesicular material, multivesicular bodies, mitochondria, and lipofuscin granules, as well as granular or paracrystalline inclusions. These alterations are similar to those described before as "dying-back oligodendrogliopathy" in diseases of toxic or immune-mediated demyelination including multiple sclerosis.
AB - Ultrastructural analysis of myelin from 8-month-old mice deficient in the myelin-associated glycoprotein revealed pronounced and characteristic alterations of the periaxonal oligodendrocyte processes, consisting of intracytoplasmic deposition of vesicular material, multivesicular bodies, mitochondria, and lipofuscin granules, as well as granular or paracrystalline inclusions. These alterations are similar to those described before as "dying-back oligodendrogliopathy" in diseases of toxic or immune-mediated demyelination including multiple sclerosis.
KW - Animals
KW - Cell Death
KW - Mice
KW - Mice, Mutant Strains
KW - Microscopy, Electron
KW - Mutation
KW - Myelin-Associated Glycoprotein
KW - Nerve Fibers, Myelinated
KW - Nervous System Diseases
KW - Oligodendroglia
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
M3 - SCORING: Journal article
C2 - 9034827
VL - 19
SP - 104
EP - 110
JO - GLIA
JF - GLIA
SN - 0894-1491
IS - 2
ER -