Duration of TCR stimulation determines costimulatory requirement of T cells
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Duration of TCR stimulation determines costimulatory requirement of T cells. / Kündig, T M; Shahinian, A; Kawai, K; Mittrücker, H W; Sebzda, E; Bachmann, M F; Mak, T W; Ohashi, P S.
In: IMMUNITY, Vol. 5, No. 1, 01.07.1996, p. 41-52.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Duration of TCR stimulation determines costimulatory requirement of T cells
AU - Kündig, T M
AU - Shahinian, A
AU - Kawai, K
AU - Mittrücker, H W
AU - Sebzda, E
AU - Bachmann, M F
AU - Mak, T W
AU - Ohashi, P S
PY - 1996/7/1
Y1 - 1996/7/1
N2 - Current models suggest that T cells that receive only signal-1 through antigenic stimulation of the T cell receptor (TCR) become anergic, but will mount an immune response when a costimulatory signal-2 is provided. Using mice deficient for an important costimulatory molecule, CD28, we show that a transient signal-1 alone, either through infection with an abortively replicating virus, or through injection of viral peptide, anergizes CD8+ T cells, demonstrating the biological relevance of T cell anergy in vivo. However, in the absence of CD28, continued presence of signal-1 alone, either through prolonged viral replication or repeated injection of peptide, prevents the induction of anergy and generates a functional T cell response in vivo.
AB - Current models suggest that T cells that receive only signal-1 through antigenic stimulation of the T cell receptor (TCR) become anergic, but will mount an immune response when a costimulatory signal-2 is provided. Using mice deficient for an important costimulatory molecule, CD28, we show that a transient signal-1 alone, either through infection with an abortively replicating virus, or through injection of viral peptide, anergizes CD8+ T cells, demonstrating the biological relevance of T cell anergy in vivo. However, in the absence of CD28, continued presence of signal-1 alone, either through prolonged viral replication or repeated injection of peptide, prevents the induction of anergy and generates a functional T cell response in vivo.
KW - Animals
KW - Antigens, CD28
KW - Antigens, Viral
KW - Clonal Deletion
KW - Cytotoxicity, Immunologic
KW - Dose-Response Relationship, Immunologic
KW - Immune Tolerance
KW - Lymphocyte Activation
KW - Lymphocytic choriomeningitis virus
KW - Mice
KW - Mice, Inbred C57BL
KW - Mice, Inbred CBA
KW - Mice, Mutant Strains
KW - Receptors, Antigen, T-Cell
KW - T-Lymphocytes, Cytotoxic
KW - Virus Replication
M3 - SCORING: Journal article
C2 - 8758893
VL - 5
SP - 41
EP - 52
JO - IMMUNITY
JF - IMMUNITY
SN - 1074-7613
IS - 1
ER -