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Duration of TCR stimulation determines costimulatory requirement of T cells

Standard

Duration of TCR stimulation determines costimulatory requirement of T cells. / Kündig, T M; Shahinian, A; Kawai, K; Mittrücker, H W; Sebzda, E; Bachmann, M F; Mak, T W; Ohashi, P S.

in: IMMUNITY, Jahrgang 5, Nr. 1, 01.07.1996, S. 41-52.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Kündig, TM, Shahinian, A, Kawai, K, Mittrücker, HW, Sebzda, E, Bachmann, MF, Mak, TW & Ohashi, PS 1996, 'Duration of TCR stimulation determines costimulatory requirement of T cells', IMMUNITY, Jg. 5, Nr. 1, S. 41-52.

APA

Kündig, T. M., Shahinian, A., Kawai, K., Mittrücker, H. W., Sebzda, E., Bachmann, M. F., Mak, T. W., & Ohashi, P. S. (1996). Duration of TCR stimulation determines costimulatory requirement of T cells. IMMUNITY, 5(1), 41-52.

Vancouver

Kündig TM, Shahinian A, Kawai K, Mittrücker HW, Sebzda E, Bachmann MF et al. Duration of TCR stimulation determines costimulatory requirement of T cells. IMMUNITY. 1996 Jul 1;5(1):41-52.

Bibtex

@article{ab1d90f971644f3aafdaa5a5f8ab7bf3,
title = "Duration of TCR stimulation determines costimulatory requirement of T cells",
abstract = "Current models suggest that T cells that receive only signal-1 through antigenic stimulation of the T cell receptor (TCR) become anergic, but will mount an immune response when a costimulatory signal-2 is provided. Using mice deficient for an important costimulatory molecule, CD28, we show that a transient signal-1 alone, either through infection with an abortively replicating virus, or through injection of viral peptide, anergizes CD8+ T cells, demonstrating the biological relevance of T cell anergy in vivo. However, in the absence of CD28, continued presence of signal-1 alone, either through prolonged viral replication or repeated injection of peptide, prevents the induction of anergy and generates a functional T cell response in vivo.",
keywords = "Animals, Antigens, CD28, Antigens, Viral, Clonal Deletion, Cytotoxicity, Immunologic, Dose-Response Relationship, Immunologic, Immune Tolerance, Lymphocyte Activation, Lymphocytic choriomeningitis virus, Mice, Mice, Inbred C57BL, Mice, Inbred CBA, Mice, Mutant Strains, Receptors, Antigen, T-Cell, T-Lymphocytes, Cytotoxic, Virus Replication",
author = "K{\"u}ndig, {T M} and A Shahinian and K Kawai and Mittr{\"u}cker, {H W} and E Sebzda and Bachmann, {M F} and Mak, {T W} and Ohashi, {P S}",
year = "1996",
month = jul,
day = "1",
language = "English",
volume = "5",
pages = "41--52",
journal = "IMMUNITY",
issn = "1074-7613",
publisher = "Cell Press",
number = "1",

}

RIS

TY - JOUR

T1 - Duration of TCR stimulation determines costimulatory requirement of T cells

AU - Kündig, T M

AU - Shahinian, A

AU - Kawai, K

AU - Mittrücker, H W

AU - Sebzda, E

AU - Bachmann, M F

AU - Mak, T W

AU - Ohashi, P S

PY - 1996/7/1

Y1 - 1996/7/1

N2 - Current models suggest that T cells that receive only signal-1 through antigenic stimulation of the T cell receptor (TCR) become anergic, but will mount an immune response when a costimulatory signal-2 is provided. Using mice deficient for an important costimulatory molecule, CD28, we show that a transient signal-1 alone, either through infection with an abortively replicating virus, or through injection of viral peptide, anergizes CD8+ T cells, demonstrating the biological relevance of T cell anergy in vivo. However, in the absence of CD28, continued presence of signal-1 alone, either through prolonged viral replication or repeated injection of peptide, prevents the induction of anergy and generates a functional T cell response in vivo.

AB - Current models suggest that T cells that receive only signal-1 through antigenic stimulation of the T cell receptor (TCR) become anergic, but will mount an immune response when a costimulatory signal-2 is provided. Using mice deficient for an important costimulatory molecule, CD28, we show that a transient signal-1 alone, either through infection with an abortively replicating virus, or through injection of viral peptide, anergizes CD8+ T cells, demonstrating the biological relevance of T cell anergy in vivo. However, in the absence of CD28, continued presence of signal-1 alone, either through prolonged viral replication or repeated injection of peptide, prevents the induction of anergy and generates a functional T cell response in vivo.

KW - Animals

KW - Antigens, CD28

KW - Antigens, Viral

KW - Clonal Deletion

KW - Cytotoxicity, Immunologic

KW - Dose-Response Relationship, Immunologic

KW - Immune Tolerance

KW - Lymphocyte Activation

KW - Lymphocytic choriomeningitis virus

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Inbred CBA

KW - Mice, Mutant Strains

KW - Receptors, Antigen, T-Cell

KW - T-Lymphocytes, Cytotoxic

KW - Virus Replication

M3 - SCORING: Journal article

C2 - 8758893

VL - 5

SP - 41

EP - 52

JO - IMMUNITY

JF - IMMUNITY

SN - 1074-7613

IS - 1

ER -