Dopaminergic response in Parkinsonian phenotype of Machado-Joseph disease.
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Dopaminergic response in Parkinsonian phenotype of Machado-Joseph disease. / Buhmann, Carsten; Bussopulos, Alexandra; Oechsner, Matthias.
In: MOVEMENT DISORD, Vol. 18, No. 2, 2, 2003, p. 219-221.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Dopaminergic response in Parkinsonian phenotype of Machado-Joseph disease.
AU - Buhmann, Carsten
AU - Bussopulos, Alexandra
AU - Oechsner, Matthias
PY - 2003
Y1 - 2003
N2 - We report on a patient with genetically proven Machado-Joseph Disease (MJD) presenting with signs indistinguishable from Parkinson's disease (PD), including levodopa response and typical levodopa-induced motor fluctuations. Only after 10 years of prolonged benefit from levodopa and different dopamine agonists (DA), the patient developed cerebellar ataxia and pyramidal signs. Preferential D3-receptor-stimulating dopamine agonists especially showed a benefit at the time, when D2 receptor binding was reduced in IBZM SPECT. This is the first report of a meaningful response to DA in MJD.
AB - We report on a patient with genetically proven Machado-Joseph Disease (MJD) presenting with signs indistinguishable from Parkinson's disease (PD), including levodopa response and typical levodopa-induced motor fluctuations. Only after 10 years of prolonged benefit from levodopa and different dopamine agonists (DA), the patient developed cerebellar ataxia and pyramidal signs. Preferential D3-receptor-stimulating dopamine agonists especially showed a benefit at the time, when D2 receptor binding was reduced in IBZM SPECT. This is the first report of a meaningful response to DA in MJD.
M3 - SCORING: Journal article
VL - 18
SP - 219
EP - 221
JO - MOVEMENT DISORD
JF - MOVEMENT DISORD
SN - 0885-3185
IS - 2
M1 - 2
ER -