Dopaminergic response in Parkinsonian phenotype of Machado-Joseph disease.

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Dopaminergic response in Parkinsonian phenotype of Machado-Joseph disease. / Buhmann, Carsten; Bussopulos, Alexandra; Oechsner, Matthias.

in: MOVEMENT DISORD, Jahrgang 18, Nr. 2, 2, 2003, S. 219-221.

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@article{11d3fb2d0f3d4011a899c6432a8a6071,
title = "Dopaminergic response in Parkinsonian phenotype of Machado-Joseph disease.",
abstract = "We report on a patient with genetically proven Machado-Joseph Disease (MJD) presenting with signs indistinguishable from Parkinson's disease (PD), including levodopa response and typical levodopa-induced motor fluctuations. Only after 10 years of prolonged benefit from levodopa and different dopamine agonists (DA), the patient developed cerebellar ataxia and pyramidal signs. Preferential D3-receptor-stimulating dopamine agonists especially showed a benefit at the time, when D2 receptor binding was reduced in IBZM SPECT. This is the first report of a meaningful response to DA in MJD.",
author = "Carsten Buhmann and Alexandra Bussopulos and Matthias Oechsner",
year = "2003",
language = "English",
volume = "18",
pages = "219--221",
journal = "MOVEMENT DISORD",
issn = "0885-3185",
publisher = "John Wiley and Sons Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Dopaminergic response in Parkinsonian phenotype of Machado-Joseph disease.

AU - Buhmann, Carsten

AU - Bussopulos, Alexandra

AU - Oechsner, Matthias

PY - 2003

Y1 - 2003

N2 - We report on a patient with genetically proven Machado-Joseph Disease (MJD) presenting with signs indistinguishable from Parkinson's disease (PD), including levodopa response and typical levodopa-induced motor fluctuations. Only after 10 years of prolonged benefit from levodopa and different dopamine agonists (DA), the patient developed cerebellar ataxia and pyramidal signs. Preferential D3-receptor-stimulating dopamine agonists especially showed a benefit at the time, when D2 receptor binding was reduced in IBZM SPECT. This is the first report of a meaningful response to DA in MJD.

AB - We report on a patient with genetically proven Machado-Joseph Disease (MJD) presenting with signs indistinguishable from Parkinson's disease (PD), including levodopa response and typical levodopa-induced motor fluctuations. Only after 10 years of prolonged benefit from levodopa and different dopamine agonists (DA), the patient developed cerebellar ataxia and pyramidal signs. Preferential D3-receptor-stimulating dopamine agonists especially showed a benefit at the time, when D2 receptor binding was reduced in IBZM SPECT. This is the first report of a meaningful response to DA in MJD.

M3 - SCORING: Journal article

VL - 18

SP - 219

EP - 221

JO - MOVEMENT DISORD

JF - MOVEMENT DISORD

SN - 0885-3185

IS - 2

M1 - 2

ER -