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Does statin therapy impact the proximal aortopathy in aortic valve disease?

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Does statin therapy impact the proximal aortopathy in aortic valve disease? / Sequeira Gross, T; Naito, S; Neumann, N; Petersen, J; Kuntze, T; Reichenspurner, H; von Kodolitsch, Y; Girdauskas, E.

In: QJM-INT J MED, Vol. 111, No. 9, 01.09.2018, p. 623-628.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Sequeira Gross, T, Naito, S, Neumann, N, Petersen, J, Kuntze, T, Reichenspurner, H, von Kodolitsch, Y & Girdauskas, E 2018, 'Does statin therapy impact the proximal aortopathy in aortic valve disease?', QJM-INT J MED, vol. 111, no. 9, pp. 623-628. https://doi.org/10.1093/qjmed/hcy129

APA

Sequeira Gross, T., Naito, S., Neumann, N., Petersen, J., Kuntze, T., Reichenspurner, H., von Kodolitsch, Y., & Girdauskas, E. (2018). Does statin therapy impact the proximal aortopathy in aortic valve disease? QJM-INT J MED, 111(9), 623-628. https://doi.org/10.1093/qjmed/hcy129

Vancouver

Sequeira Gross T, Naito S, Neumann N, Petersen J, Kuntze T, Reichenspurner H et al. Does statin therapy impact the proximal aortopathy in aortic valve disease? QJM-INT J MED. 2018 Sep 1;111(9):623-628. https://doi.org/10.1093/qjmed/hcy129

Bibtex

@article{2ec85d9dc72b44c2a01356d868e4aff4,
title = "Does statin therapy impact the proximal aortopathy in aortic valve disease?",
abstract = "Background: Studies have demonstrated that statin therapy decreases the growth rate of abdominal aneurysms. However, the effect of statin therapy on the proximal aortic disease has not been sufficiently elucidated.Aim: We aimed to analyse the association between statin treatment and the severity of proximal aortopathy in patients with aortic valve disease.Design: Cross-sectional study.Methods: We prospectively identified 458 patients who were referred for aortic valve surgery from 2008 to 2014. Pre-operative measurement of the proximal aorta was performed by TEE, CT or MRT scan. Data of dyslipidemia treatment was obtained by questionnaire.Results: The mean ascending aortic diameter in the whole study population was comparable in patients with vs. without statin therapy (i.e. 42.7 mm vs. 43.6 mm, P = 0.46). Logistic regression analysis showed no significant association between statin therapy and proximal aortopathy ≥ 40 mm in the whole study group (OR = 0.69, P = 0.10). For the BAV sub-group, HDL (OR = 0.54, P = 0.038) and cholesterol levels (OR = 2.00, P = 0.038) were found significantly associated with the proximal aortic disease. In the BAV cohort, the statin users with target HDL levels presented a significantly smaller proximal aortic diameter (40.1 mm vs. 46 mm, P = 0.02).Conclusion: Pre-operative statin therapy demonstrated no significant association with the expression of proximal aortopathy. However, more than 40% of the statin users presented uncontrolled lipid levels at the time of the study. In the BAV sub-group, the statins users with target HDL levels showed a significantly smaller ascending aorta diameter. Target HDL and cholesterol levels were strongly associated with proximal aortic dilation in BAV patients.",
keywords = "Adult, Aged, Aged, 80 and over, Aortic Diseases/complications, Aortic Valve/diagnostic imaging, Bicuspid Aortic Valve Disease, Cross-Sectional Studies, Female, Heart Defects, Congenital/diagnostic imaging, Heart Valve Diseases/diagnostic imaging, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use, Lipids/blood, Logistic Models, Male, Middle Aged, Multivariate Analysis, Preoperative Care, Prospective Studies, Severity of Illness Index",
author = "{Sequeira Gross}, T and S Naito and N Neumann and J Petersen and T Kuntze and H Reichenspurner and {von Kodolitsch}, Y and E Girdauskas",
year = "2018",
month = sep,
day = "1",
doi = "10.1093/qjmed/hcy129",
language = "English",
volume = "111",
pages = "623--628",
journal = "QJM-INT J MED",
issn = "1460-2725",
publisher = "Oxford University Press",
number = "9",

}

RIS

TY - JOUR

T1 - Does statin therapy impact the proximal aortopathy in aortic valve disease?

AU - Sequeira Gross, T

AU - Naito, S

AU - Neumann, N

AU - Petersen, J

AU - Kuntze, T

AU - Reichenspurner, H

AU - von Kodolitsch, Y

AU - Girdauskas, E

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Background: Studies have demonstrated that statin therapy decreases the growth rate of abdominal aneurysms. However, the effect of statin therapy on the proximal aortic disease has not been sufficiently elucidated.Aim: We aimed to analyse the association between statin treatment and the severity of proximal aortopathy in patients with aortic valve disease.Design: Cross-sectional study.Methods: We prospectively identified 458 patients who were referred for aortic valve surgery from 2008 to 2014. Pre-operative measurement of the proximal aorta was performed by TEE, CT or MRT scan. Data of dyslipidemia treatment was obtained by questionnaire.Results: The mean ascending aortic diameter in the whole study population was comparable in patients with vs. without statin therapy (i.e. 42.7 mm vs. 43.6 mm, P = 0.46). Logistic regression analysis showed no significant association between statin therapy and proximal aortopathy ≥ 40 mm in the whole study group (OR = 0.69, P = 0.10). For the BAV sub-group, HDL (OR = 0.54, P = 0.038) and cholesterol levels (OR = 2.00, P = 0.038) were found significantly associated with the proximal aortic disease. In the BAV cohort, the statin users with target HDL levels presented a significantly smaller proximal aortic diameter (40.1 mm vs. 46 mm, P = 0.02).Conclusion: Pre-operative statin therapy demonstrated no significant association with the expression of proximal aortopathy. However, more than 40% of the statin users presented uncontrolled lipid levels at the time of the study. In the BAV sub-group, the statins users with target HDL levels showed a significantly smaller ascending aorta diameter. Target HDL and cholesterol levels were strongly associated with proximal aortic dilation in BAV patients.

AB - Background: Studies have demonstrated that statin therapy decreases the growth rate of abdominal aneurysms. However, the effect of statin therapy on the proximal aortic disease has not been sufficiently elucidated.Aim: We aimed to analyse the association between statin treatment and the severity of proximal aortopathy in patients with aortic valve disease.Design: Cross-sectional study.Methods: We prospectively identified 458 patients who were referred for aortic valve surgery from 2008 to 2014. Pre-operative measurement of the proximal aorta was performed by TEE, CT or MRT scan. Data of dyslipidemia treatment was obtained by questionnaire.Results: The mean ascending aortic diameter in the whole study population was comparable in patients with vs. without statin therapy (i.e. 42.7 mm vs. 43.6 mm, P = 0.46). Logistic regression analysis showed no significant association between statin therapy and proximal aortopathy ≥ 40 mm in the whole study group (OR = 0.69, P = 0.10). For the BAV sub-group, HDL (OR = 0.54, P = 0.038) and cholesterol levels (OR = 2.00, P = 0.038) were found significantly associated with the proximal aortic disease. In the BAV cohort, the statin users with target HDL levels presented a significantly smaller proximal aortic diameter (40.1 mm vs. 46 mm, P = 0.02).Conclusion: Pre-operative statin therapy demonstrated no significant association with the expression of proximal aortopathy. However, more than 40% of the statin users presented uncontrolled lipid levels at the time of the study. In the BAV sub-group, the statins users with target HDL levels showed a significantly smaller ascending aorta diameter. Target HDL and cholesterol levels were strongly associated with proximal aortic dilation in BAV patients.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Aortic Diseases/complications

KW - Aortic Valve/diagnostic imaging

KW - Bicuspid Aortic Valve Disease

KW - Cross-Sectional Studies

KW - Female

KW - Heart Defects, Congenital/diagnostic imaging

KW - Heart Valve Diseases/diagnostic imaging

KW - Humans

KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use

KW - Lipids/blood

KW - Logistic Models

KW - Male

KW - Middle Aged

KW - Multivariate Analysis

KW - Preoperative Care

KW - Prospective Studies

KW - Severity of Illness Index

U2 - 10.1093/qjmed/hcy129

DO - 10.1093/qjmed/hcy129

M3 - SCORING: Journal article

C2 - 29917097

VL - 111

SP - 623

EP - 628

JO - QJM-INT J MED

JF - QJM-INT J MED

SN - 1460-2725

IS - 9

ER -