Does statin therapy impact the proximal aortopathy in aortic valve disease?
Standard
Does statin therapy impact the proximal aortopathy in aortic valve disease? / Sequeira Gross, T; Naito, S; Neumann, N; Petersen, J; Kuntze, T; Reichenspurner, H; von Kodolitsch, Y; Girdauskas, E.
in: QJM-INT J MED, Jahrgang 111, Nr. 9, 01.09.2018, S. 623-628.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Does statin therapy impact the proximal aortopathy in aortic valve disease?
AU - Sequeira Gross, T
AU - Naito, S
AU - Neumann, N
AU - Petersen, J
AU - Kuntze, T
AU - Reichenspurner, H
AU - von Kodolitsch, Y
AU - Girdauskas, E
PY - 2018/9/1
Y1 - 2018/9/1
N2 - Background: Studies have demonstrated that statin therapy decreases the growth rate of abdominal aneurysms. However, the effect of statin therapy on the proximal aortic disease has not been sufficiently elucidated.Aim: We aimed to analyse the association between statin treatment and the severity of proximal aortopathy in patients with aortic valve disease.Design: Cross-sectional study.Methods: We prospectively identified 458 patients who were referred for aortic valve surgery from 2008 to 2014. Pre-operative measurement of the proximal aorta was performed by TEE, CT or MRT scan. Data of dyslipidemia treatment was obtained by questionnaire.Results: The mean ascending aortic diameter in the whole study population was comparable in patients with vs. without statin therapy (i.e. 42.7 mm vs. 43.6 mm, P = 0.46). Logistic regression analysis showed no significant association between statin therapy and proximal aortopathy ≥ 40 mm in the whole study group (OR = 0.69, P = 0.10). For the BAV sub-group, HDL (OR = 0.54, P = 0.038) and cholesterol levels (OR = 2.00, P = 0.038) were found significantly associated with the proximal aortic disease. In the BAV cohort, the statin users with target HDL levels presented a significantly smaller proximal aortic diameter (40.1 mm vs. 46 mm, P = 0.02).Conclusion: Pre-operative statin therapy demonstrated no significant association with the expression of proximal aortopathy. However, more than 40% of the statin users presented uncontrolled lipid levels at the time of the study. In the BAV sub-group, the statins users with target HDL levels showed a significantly smaller ascending aorta diameter. Target HDL and cholesterol levels were strongly associated with proximal aortic dilation in BAV patients.
AB - Background: Studies have demonstrated that statin therapy decreases the growth rate of abdominal aneurysms. However, the effect of statin therapy on the proximal aortic disease has not been sufficiently elucidated.Aim: We aimed to analyse the association between statin treatment and the severity of proximal aortopathy in patients with aortic valve disease.Design: Cross-sectional study.Methods: We prospectively identified 458 patients who were referred for aortic valve surgery from 2008 to 2014. Pre-operative measurement of the proximal aorta was performed by TEE, CT or MRT scan. Data of dyslipidemia treatment was obtained by questionnaire.Results: The mean ascending aortic diameter in the whole study population was comparable in patients with vs. without statin therapy (i.e. 42.7 mm vs. 43.6 mm, P = 0.46). Logistic regression analysis showed no significant association between statin therapy and proximal aortopathy ≥ 40 mm in the whole study group (OR = 0.69, P = 0.10). For the BAV sub-group, HDL (OR = 0.54, P = 0.038) and cholesterol levels (OR = 2.00, P = 0.038) were found significantly associated with the proximal aortic disease. In the BAV cohort, the statin users with target HDL levels presented a significantly smaller proximal aortic diameter (40.1 mm vs. 46 mm, P = 0.02).Conclusion: Pre-operative statin therapy demonstrated no significant association with the expression of proximal aortopathy. However, more than 40% of the statin users presented uncontrolled lipid levels at the time of the study. In the BAV sub-group, the statins users with target HDL levels showed a significantly smaller ascending aorta diameter. Target HDL and cholesterol levels were strongly associated with proximal aortic dilation in BAV patients.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Aortic Diseases/complications
KW - Aortic Valve/diagnostic imaging
KW - Bicuspid Aortic Valve Disease
KW - Cross-Sectional Studies
KW - Female
KW - Heart Defects, Congenital/diagnostic imaging
KW - Heart Valve Diseases/diagnostic imaging
KW - Humans
KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use
KW - Lipids/blood
KW - Logistic Models
KW - Male
KW - Middle Aged
KW - Multivariate Analysis
KW - Preoperative Care
KW - Prospective Studies
KW - Severity of Illness Index
U2 - 10.1093/qjmed/hcy129
DO - 10.1093/qjmed/hcy129
M3 - SCORING: Journal article
C2 - 29917097
VL - 111
SP - 623
EP - 628
JO - QJM-INT J MED
JF - QJM-INT J MED
SN - 1460-2725
IS - 9
ER -