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DNA damage foci: Meaning and significance

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DNA damage foci: Meaning and significance. / Rothkamm, Kai; Barnard, Stephen; Moquet, Jayne; Ellender, Michele; Rana, Zohaib; Burdak-Rothkamm, Susanne.

In: ENVIRON MOL MUTAGEN, Vol. 56, No. 6, 01.07.2015, p. 491-504.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Rothkamm, K, Barnard, S, Moquet, J, Ellender, M, Rana, Z & Burdak-Rothkamm, S 2015, 'DNA damage foci: Meaning and significance', ENVIRON MOL MUTAGEN, vol. 56, no. 6, pp. 491-504. https://doi.org/10.1002/em.21944

APA

Rothkamm, K., Barnard, S., Moquet, J., Ellender, M., Rana, Z., & Burdak-Rothkamm, S. (2015). DNA damage foci: Meaning and significance. ENVIRON MOL MUTAGEN, 56(6), 491-504. https://doi.org/10.1002/em.21944

Vancouver

Rothkamm K, Barnard S, Moquet J, Ellender M, Rana Z, Burdak-Rothkamm S. DNA damage foci: Meaning and significance. ENVIRON MOL MUTAGEN. 2015 Jul 1;56(6):491-504. https://doi.org/10.1002/em.21944

Bibtex

@article{5ad67e02b697430abbd1eed53434de9a,
title = "DNA damage foci: Meaning and significance",
abstract = "The discovery of DNA damage response proteins such as γH2AX, ATM, 53BP1, RAD51, and the MRE11/RAD50/NBS1 complex, that accumulate and/or are modified in the vicinity of a chromosomal DNA double-strand break to form microscopically visible, subnuclear foci, has revolutionized the detection of these lesions and has enabled studies of the cellular machinery that contributes to their repair. Double-strand breaks are induced directly by a number of physical and chemical agents, including ionizing radiation and radiomimetic drugs, but can also arise as secondary lesions during replication and DNA repair following exposure to a wide range of genotoxins. Here we aim to review the biological meaning and significance of DNA damage foci, looking specifically at a range of different settings in which such markers of DNA damage and repair are being studied and interpreted. Environ. Mol. Mutagen. 56:491-504, 2015. {\textcopyright} Wiley Periodicals, Inc.",
author = "Kai Rothkamm and Stephen Barnard and Jayne Moquet and Michele Ellender and Zohaib Rana and Susanne Burdak-Rothkamm",
note = "{\textcopyright} 2015 Wiley Periodicals, Inc.",
year = "2015",
month = jul,
day = "1",
doi = "10.1002/em.21944",
language = "English",
volume = "56",
pages = "491--504",
journal = "ENVIRON MOL MUTAGEN",
issn = "0893-6692",
publisher = "Wiley-Liss Inc.",
number = "6",

}

RIS

TY - JOUR

T1 - DNA damage foci: Meaning and significance

AU - Rothkamm, Kai

AU - Barnard, Stephen

AU - Moquet, Jayne

AU - Ellender, Michele

AU - Rana, Zohaib

AU - Burdak-Rothkamm, Susanne

N1 - © 2015 Wiley Periodicals, Inc.

PY - 2015/7/1

Y1 - 2015/7/1

N2 - The discovery of DNA damage response proteins such as γH2AX, ATM, 53BP1, RAD51, and the MRE11/RAD50/NBS1 complex, that accumulate and/or are modified in the vicinity of a chromosomal DNA double-strand break to form microscopically visible, subnuclear foci, has revolutionized the detection of these lesions and has enabled studies of the cellular machinery that contributes to their repair. Double-strand breaks are induced directly by a number of physical and chemical agents, including ionizing radiation and radiomimetic drugs, but can also arise as secondary lesions during replication and DNA repair following exposure to a wide range of genotoxins. Here we aim to review the biological meaning and significance of DNA damage foci, looking specifically at a range of different settings in which such markers of DNA damage and repair are being studied and interpreted. Environ. Mol. Mutagen. 56:491-504, 2015. © Wiley Periodicals, Inc.

AB - The discovery of DNA damage response proteins such as γH2AX, ATM, 53BP1, RAD51, and the MRE11/RAD50/NBS1 complex, that accumulate and/or are modified in the vicinity of a chromosomal DNA double-strand break to form microscopically visible, subnuclear foci, has revolutionized the detection of these lesions and has enabled studies of the cellular machinery that contributes to their repair. Double-strand breaks are induced directly by a number of physical and chemical agents, including ionizing radiation and radiomimetic drugs, but can also arise as secondary lesions during replication and DNA repair following exposure to a wide range of genotoxins. Here we aim to review the biological meaning and significance of DNA damage foci, looking specifically at a range of different settings in which such markers of DNA damage and repair are being studied and interpreted. Environ. Mol. Mutagen. 56:491-504, 2015. © Wiley Periodicals, Inc.

U2 - 10.1002/em.21944

DO - 10.1002/em.21944

M3 - SCORING: Journal article

C2 - 25773265

VL - 56

SP - 491

EP - 504

JO - ENVIRON MOL MUTAGEN

JF - ENVIRON MOL MUTAGEN

SN - 0893-6692

IS - 6

ER -