DNA cytophotometry in adrenocortical tumours: a clinicomorphological study of 66 cases.
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DNA cytophotometry in adrenocortical tumours: a clinicomorphological study of 66 cases. / Padberg, B C; Lauritzen, I; Achilles, Eike-Gert; Holl, K; Bressel, M; Klöppel, G; Dralle, H; Schröder, S.
In: Virchows Arch A Pathol Anat Histopathol, Vol. 419, No. 3, 3, 1991, p. 167-170.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - DNA cytophotometry in adrenocortical tumours: a clinicomorphological study of 66 cases.
AU - Padberg, B C
AU - Lauritzen, I
AU - Achilles, Eike-Gert
AU - Holl, K
AU - Bressel, M
AU - Klöppel, G
AU - Dralle, H
AU - Schröder, S
PY - 1991
Y1 - 1991
N2 - Surgical specimens of 66 adrenocortical tumours were investigated by conventional microscopy and DNA cytophotometry. Histologically, 50 neoplasms were classified as adenomas and 16 as carcinomas. In only 8 of the latter cases were distant metastases and/or a lethal outcome recorded. On single cell scanning cytophotometry either non-euploid or aneuploid DNA histograms were identified in 24 of 50 adenomas (48%) and in 14 of 16 carcinomas (88%). The two carcinomas exhibiting euploid DNA distributions fell into the group of 7 malignancies which are recurrence-free so far. From these findings it is concluded that DNA measurements have no diagnostic and only limited prognostic value in neoplasms of the adrenal cortex.
AB - Surgical specimens of 66 adrenocortical tumours were investigated by conventional microscopy and DNA cytophotometry. Histologically, 50 neoplasms were classified as adenomas and 16 as carcinomas. In only 8 of the latter cases were distant metastases and/or a lethal outcome recorded. On single cell scanning cytophotometry either non-euploid or aneuploid DNA histograms were identified in 24 of 50 adenomas (48%) and in 14 of 16 carcinomas (88%). The two carcinomas exhibiting euploid DNA distributions fell into the group of 7 malignancies which are recurrence-free so far. From these findings it is concluded that DNA measurements have no diagnostic and only limited prognostic value in neoplasms of the adrenal cortex.
M3 - SCORING: Zeitschriftenaufsatz
VL - 419
SP - 167
EP - 170
JO - VIRCHOWS ARCH
JF - VIRCHOWS ARCH
SN - 0945-6317
IS - 3
M1 - 3
ER -