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Dissociation between bone resorption and bone formation in osteopenic transgenic mice

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Dissociation between bone resorption and bone formation in osteopenic transgenic mice. / Corral, D A; Amling, M; Priemel, M; Loyer, E; Fuchs, S; Ducy, P; Baron, R; Karsenty, G.

In: P NATL ACAD SCI USA, Vol. 95, No. 23, 10.11.1998, p. 13835-40.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Corral, DA, Amling, M, Priemel, M, Loyer, E, Fuchs, S, Ducy, P, Baron, R & Karsenty, G 1998, 'Dissociation between bone resorption and bone formation in osteopenic transgenic mice', P NATL ACAD SCI USA, vol. 95, no. 23, pp. 13835-40.

APA

Corral, D. A., Amling, M., Priemel, M., Loyer, E., Fuchs, S., Ducy, P., Baron, R., & Karsenty, G. (1998). Dissociation between bone resorption and bone formation in osteopenic transgenic mice. P NATL ACAD SCI USA, 95(23), 13835-40.

Vancouver

Corral DA, Amling M, Priemel M, Loyer E, Fuchs S, Ducy P et al. Dissociation between bone resorption and bone formation in osteopenic transgenic mice. P NATL ACAD SCI USA. 1998 Nov 10;95(23):13835-40.

Bibtex

@article{b8a52ef147a84b12b642e688ac376bad,
title = "Dissociation between bone resorption and bone formation in osteopenic transgenic mice",
abstract = "Bone mass is maintained constant in vertebrates through bone remodeling (BR). BR is characterized by osteoclastic resorption of preexisting bone followed by de novo bone formation by osteoblasts. This sequence of events and the fact that bone mass remains constant in physiological situation lead to the assumption that resorption and formation are regulated by each other during BR. Recent evidence shows that cells of the osteoblastic lineage are involved in osteoclast differentiation. However, the existence of a functional link between the two activities, formation and resorption, has never been shown in vivo. To define the role of bone formation in the control of bone resorption, we generated an inducible osteoblast ablation mouse model. These mice developed a reversible osteopenia. Functional analyses showed that in the absence of bone formation, bone resorption continued to occur normally, leading to an osteoporosis of controllable severity, whose appearance could be prevented by an antiresorptive agent. This study establishes that bone formation and/or bone mass do not control the extent of bone resorption in vivo.",
keywords = "Animals, Bone Diseases, Metabolic, Bone Remodeling, Bone Resorption, Mice, Mice, Transgenic, Osteoblasts, Osteocalcin, Osteoclasts, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.",
author = "Corral, {D A} and M Amling and M Priemel and E Loyer and S Fuchs and P Ducy and R Baron and G Karsenty",
year = "1998",
month = nov,
day = "10",
language = "English",
volume = "95",
pages = "13835--40",
journal = "P NATL ACAD SCI USA",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "23",

}

RIS

TY - JOUR

T1 - Dissociation between bone resorption and bone formation in osteopenic transgenic mice

AU - Corral, D A

AU - Amling, M

AU - Priemel, M

AU - Loyer, E

AU - Fuchs, S

AU - Ducy, P

AU - Baron, R

AU - Karsenty, G

PY - 1998/11/10

Y1 - 1998/11/10

N2 - Bone mass is maintained constant in vertebrates through bone remodeling (BR). BR is characterized by osteoclastic resorption of preexisting bone followed by de novo bone formation by osteoblasts. This sequence of events and the fact that bone mass remains constant in physiological situation lead to the assumption that resorption and formation are regulated by each other during BR. Recent evidence shows that cells of the osteoblastic lineage are involved in osteoclast differentiation. However, the existence of a functional link between the two activities, formation and resorption, has never been shown in vivo. To define the role of bone formation in the control of bone resorption, we generated an inducible osteoblast ablation mouse model. These mice developed a reversible osteopenia. Functional analyses showed that in the absence of bone formation, bone resorption continued to occur normally, leading to an osteoporosis of controllable severity, whose appearance could be prevented by an antiresorptive agent. This study establishes that bone formation and/or bone mass do not control the extent of bone resorption in vivo.

AB - Bone mass is maintained constant in vertebrates through bone remodeling (BR). BR is characterized by osteoclastic resorption of preexisting bone followed by de novo bone formation by osteoblasts. This sequence of events and the fact that bone mass remains constant in physiological situation lead to the assumption that resorption and formation are regulated by each other during BR. Recent evidence shows that cells of the osteoblastic lineage are involved in osteoclast differentiation. However, the existence of a functional link between the two activities, formation and resorption, has never been shown in vivo. To define the role of bone formation in the control of bone resorption, we generated an inducible osteoblast ablation mouse model. These mice developed a reversible osteopenia. Functional analyses showed that in the absence of bone formation, bone resorption continued to occur normally, leading to an osteoporosis of controllable severity, whose appearance could be prevented by an antiresorptive agent. This study establishes that bone formation and/or bone mass do not control the extent of bone resorption in vivo.

KW - Animals

KW - Bone Diseases, Metabolic

KW - Bone Remodeling

KW - Bone Resorption

KW - Mice

KW - Mice, Transgenic

KW - Osteoblasts

KW - Osteocalcin

KW - Osteoclasts

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Research Support, U.S. Gov't, P.H.S.

M3 - SCORING: Journal article

C2 - 9811887

VL - 95

SP - 13835

EP - 13840

JO - P NATL ACAD SCI USA

JF - P NATL ACAD SCI USA

SN - 0027-8424

IS - 23

ER -