Dissociation between bone resorption and bone formation in osteopenic transgenic mice
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Dissociation between bone resorption and bone formation in osteopenic transgenic mice. / Corral, D A; Amling, M; Priemel, M; Loyer, E; Fuchs, S; Ducy, P; Baron, R; Karsenty, G.
in: P NATL ACAD SCI USA, Jahrgang 95, Nr. 23, 10.11.1998, S. 13835-40.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Dissociation between bone resorption and bone formation in osteopenic transgenic mice
AU - Corral, D A
AU - Amling, M
AU - Priemel, M
AU - Loyer, E
AU - Fuchs, S
AU - Ducy, P
AU - Baron, R
AU - Karsenty, G
PY - 1998/11/10
Y1 - 1998/11/10
N2 - Bone mass is maintained constant in vertebrates through bone remodeling (BR). BR is characterized by osteoclastic resorption of preexisting bone followed by de novo bone formation by osteoblasts. This sequence of events and the fact that bone mass remains constant in physiological situation lead to the assumption that resorption and formation are regulated by each other during BR. Recent evidence shows that cells of the osteoblastic lineage are involved in osteoclast differentiation. However, the existence of a functional link between the two activities, formation and resorption, has never been shown in vivo. To define the role of bone formation in the control of bone resorption, we generated an inducible osteoblast ablation mouse model. These mice developed a reversible osteopenia. Functional analyses showed that in the absence of bone formation, bone resorption continued to occur normally, leading to an osteoporosis of controllable severity, whose appearance could be prevented by an antiresorptive agent. This study establishes that bone formation and/or bone mass do not control the extent of bone resorption in vivo.
AB - Bone mass is maintained constant in vertebrates through bone remodeling (BR). BR is characterized by osteoclastic resorption of preexisting bone followed by de novo bone formation by osteoblasts. This sequence of events and the fact that bone mass remains constant in physiological situation lead to the assumption that resorption and formation are regulated by each other during BR. Recent evidence shows that cells of the osteoblastic lineage are involved in osteoclast differentiation. However, the existence of a functional link between the two activities, formation and resorption, has never been shown in vivo. To define the role of bone formation in the control of bone resorption, we generated an inducible osteoblast ablation mouse model. These mice developed a reversible osteopenia. Functional analyses showed that in the absence of bone formation, bone resorption continued to occur normally, leading to an osteoporosis of controllable severity, whose appearance could be prevented by an antiresorptive agent. This study establishes that bone formation and/or bone mass do not control the extent of bone resorption in vivo.
KW - Animals
KW - Bone Diseases, Metabolic
KW - Bone Remodeling
KW - Bone Resorption
KW - Mice
KW - Mice, Transgenic
KW - Osteoblasts
KW - Osteocalcin
KW - Osteoclasts
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
KW - Research Support, U.S. Gov't, P.H.S.
M3 - SCORING: Journal article
C2 - 9811887
VL - 95
SP - 13835
EP - 13840
JO - P NATL ACAD SCI USA
JF - P NATL ACAD SCI USA
SN - 0027-8424
IS - 23
ER -