Disorientation in Time and Place in Old Age: Longitudinal Evidence from Three Old Age Cohorts in Germany (AgeDifferent.de Platform)
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Disorientation in Time and Place in Old Age: Longitudinal Evidence from Three Old Age Cohorts in Germany (AgeDifferent.de Platform). / Rodriguez, Francisca S; Pabst, Alexander; Heser, Kathrin; Kleineidam, Luca; Hajek, Andre; Eisele, Marion; Röhr, Susanne; Löbner, Margrit; Wiese, Birgitt; Angermeyer, Matthias; Maier, Wolfgang; Scherer, Martin; Wagner, Michael; König, Hans-Helmut; Riedel-Heller, Steffi.
In: J ALZHEIMERS DIS, Vol. 79, No. 4, 2021, p. 1589-1599.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Disorientation in Time and Place in Old Age: Longitudinal Evidence from Three Old Age Cohorts in Germany (AgeDifferent.de Platform)
AU - Rodriguez, Francisca S
AU - Pabst, Alexander
AU - Heser, Kathrin
AU - Kleineidam, Luca
AU - Hajek, Andre
AU - Eisele, Marion
AU - Röhr, Susanne
AU - Löbner, Margrit
AU - Wiese, Birgitt
AU - Angermeyer, Matthias
AU - Maier, Wolfgang
AU - Scherer, Martin
AU - Wagner, Michael
AU - König, Hans-Helmut
AU - Riedel-Heller, Steffi
PY - 2021
Y1 - 2021
N2 - Background:Only little evidence is available on disorientation, one of the most challenging symptoms of Alzheimer’s disease and related dementias.Objectives:The aim of this study was to investigate the prevalence of disorientation in older age in association with the level of cognitive status, personal characteristics, and life events.Methods:Three longitudinal population-based cohort studies on cognitive health of elderly adults were harmonized (LEILA 75 + , AgeCoDe/AgeQualiDe, AgeMooDe). Participants who completed a baseline and at least one follow-up assessment of cognitive functioning and who did not have stroke, Parkinson’s disease, atherosclerosis, kidney disease, and/or alcoholism were included in the analysis (n = 2135, 72.6% female, mean age 80.2 years). Data was collected in standardized interviews and questionnaires with the participant, a proxy informant, and the participant’s general practitioner.Results:Making three errors in the MMSE other than in the questions on orientation (MMSEwo) came with a probability of 7.8% for disorientation, making ten errors with a probability of 88.9%. A lower MMSEwo score (HR 0.75, CI 95 0.71–0.79, p < 0.001), older age (HR 1.11, CI 95 1.08–1.14, p < 0.001), and living in a nursing home (HR 1.64, CI 95 1.02–2.64, p = 0.042) were associated with incident disorientation. Impairments in walking (OR 2.41, CI 95 1.16–4.99, p = 0.018) were associated with a greater probability for prevalent disorientation. None of the life events were significant.Conclusion:Our findings suggest that disorientation is primarily associated with cognitive status. Regular walking activities might possibly reduce the risk for disorientation but further research is necessary.
AB - Background:Only little evidence is available on disorientation, one of the most challenging symptoms of Alzheimer’s disease and related dementias.Objectives:The aim of this study was to investigate the prevalence of disorientation in older age in association with the level of cognitive status, personal characteristics, and life events.Methods:Three longitudinal population-based cohort studies on cognitive health of elderly adults were harmonized (LEILA 75 + , AgeCoDe/AgeQualiDe, AgeMooDe). Participants who completed a baseline and at least one follow-up assessment of cognitive functioning and who did not have stroke, Parkinson’s disease, atherosclerosis, kidney disease, and/or alcoholism were included in the analysis (n = 2135, 72.6% female, mean age 80.2 years). Data was collected in standardized interviews and questionnaires with the participant, a proxy informant, and the participant’s general practitioner.Results:Making three errors in the MMSE other than in the questions on orientation (MMSEwo) came with a probability of 7.8% for disorientation, making ten errors with a probability of 88.9%. A lower MMSEwo score (HR 0.75, CI 95 0.71–0.79, p < 0.001), older age (HR 1.11, CI 95 1.08–1.14, p < 0.001), and living in a nursing home (HR 1.64, CI 95 1.02–2.64, p = 0.042) were associated with incident disorientation. Impairments in walking (OR 2.41, CI 95 1.16–4.99, p = 0.018) were associated with a greater probability for prevalent disorientation. None of the life events were significant.Conclusion:Our findings suggest that disorientation is primarily associated with cognitive status. Regular walking activities might possibly reduce the risk for disorientation but further research is necessary.
U2 - 10.3233/JAD-201008
DO - 10.3233/JAD-201008
M3 - SCORING: Journal article
VL - 79
SP - 1589
EP - 1599
JO - J ALZHEIMERS DIS
JF - J ALZHEIMERS DIS
SN - 1387-2877
IS - 4
ER -
