Disorientation in Time and Place in Old Age: Longitudinal Evidence from Three Old Age Cohorts in Germany (AgeDifferent.de Platform)

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Disorientation in Time and Place in Old Age: Longitudinal Evidence from Three Old Age Cohorts in Germany (AgeDifferent.de Platform). / Rodriguez, Francisca S; Pabst, Alexander; Heser, Kathrin; Kleineidam, Luca; Hajek, Andre; Eisele, Marion; Röhr, Susanne; Löbner, Margrit; Wiese, Birgitt; Angermeyer, Matthias; Maier, Wolfgang; Scherer, Martin; Wagner, Michael; König, Hans-Helmut; Riedel-Heller, Steffi.

in: J ALZHEIMERS DIS, Jahrgang 79, Nr. 4, 2021, S. 1589-1599.

Publikationen: SCORING: Beitrag in Fachzeitschrift/ZeitungSCORING: ZeitschriftenaufsatzForschungBegutachtung

Harvard

Rodriguez, FS, Pabst, A, Heser, K, Kleineidam, L, Hajek, A, Eisele, M, Röhr, S, Löbner, M, Wiese, B, Angermeyer, M, Maier, W, Scherer, M, Wagner, M, König, H-H & Riedel-Heller, S 2021, 'Disorientation in Time and Place in Old Age: Longitudinal Evidence from Three Old Age Cohorts in Germany (AgeDifferent.de Platform)', J ALZHEIMERS DIS, Jg. 79, Nr. 4, S. 1589-1599. https://doi.org/10.3233/JAD-201008

APA

Rodriguez, F. S., Pabst, A., Heser, K., Kleineidam, L., Hajek, A., Eisele, M., Röhr, S., Löbner, M., Wiese, B., Angermeyer, M., Maier, W., Scherer, M., Wagner, M., König, H-H., & Riedel-Heller, S. (2021). Disorientation in Time and Place in Old Age: Longitudinal Evidence from Three Old Age Cohorts in Germany (AgeDifferent.de Platform). J ALZHEIMERS DIS, 79(4), 1589-1599. https://doi.org/10.3233/JAD-201008

Vancouver

Bibtex

@article{dafdf721a7ec45039f3499a125cd3b26,
title = "Disorientation in Time and Place in Old Age: Longitudinal Evidence from Three Old Age Cohorts in Germany (AgeDifferent.de Platform)",
abstract = "Background:Only little evidence is available on disorientation, one of the most challenging symptoms of Alzheimer{\textquoteright}s disease and related dementias.Objectives:The aim of this study was to investigate the prevalence of disorientation in older age in association with the level of cognitive status, personal characteristics, and life events.Methods:Three longitudinal population-based cohort studies on cognitive health of elderly adults were harmonized (LEILA 75 + , AgeCoDe/AgeQualiDe, AgeMooDe). Participants who completed a baseline and at least one follow-up assessment of cognitive functioning and who did not have stroke, Parkinson{\textquoteright}s disease, atherosclerosis, kidney disease, and/or alcoholism were included in the analysis (n = 2135, 72.6% female, mean age 80.2 years). Data was collected in standardized interviews and questionnaires with the participant, a proxy informant, and the participant{\textquoteright}s general practitioner.Results:Making three errors in the MMSE other than in the questions on orientation (MMSEwo) came with a probability of 7.8% for disorientation, making ten errors with a probability of 88.9%. A lower MMSEwo score (HR 0.75, CI 95 0.71–0.79, p < 0.001), older age (HR 1.11, CI 95 1.08–1.14, p < 0.001), and living in a nursing home (HR 1.64, CI 95 1.02–2.64, p = 0.042) were associated with incident disorientation. Impairments in walking (OR 2.41, CI 95 1.16–4.99, p = 0.018) were associated with a greater probability for prevalent disorientation. None of the life events were significant.Conclusion:Our findings suggest that disorientation is primarily associated with cognitive status. Regular walking activities might possibly reduce the risk for disorientation but further research is necessary.",
author = "Rodriguez, {Francisca S} and Alexander Pabst and Kathrin Heser and Luca Kleineidam and Andre Hajek and Marion Eisele and Susanne R{\"o}hr and Margrit L{\"o}bner and Birgitt Wiese and Matthias Angermeyer and Wolfgang Maier and Martin Scherer and Michael Wagner and Hans-Helmut K{\"o}nig and Steffi Riedel-Heller",
year = "2021",
doi = "10.3233/JAD-201008",
language = "English",
volume = "79",
pages = "1589--1599",
journal = "J ALZHEIMERS DIS",
issn = "1387-2877",
publisher = "IOS Press",
number = "4",

}

RIS

TY - JOUR

T1 - Disorientation in Time and Place in Old Age: Longitudinal Evidence from Three Old Age Cohorts in Germany (AgeDifferent.de Platform)

AU - Rodriguez, Francisca S

AU - Pabst, Alexander

AU - Heser, Kathrin

AU - Kleineidam, Luca

AU - Hajek, Andre

AU - Eisele, Marion

AU - Röhr, Susanne

AU - Löbner, Margrit

AU - Wiese, Birgitt

AU - Angermeyer, Matthias

AU - Maier, Wolfgang

AU - Scherer, Martin

AU - Wagner, Michael

AU - König, Hans-Helmut

AU - Riedel-Heller, Steffi

PY - 2021

Y1 - 2021

N2 - Background:Only little evidence is available on disorientation, one of the most challenging symptoms of Alzheimer’s disease and related dementias.Objectives:The aim of this study was to investigate the prevalence of disorientation in older age in association with the level of cognitive status, personal characteristics, and life events.Methods:Three longitudinal population-based cohort studies on cognitive health of elderly adults were harmonized (LEILA 75 + , AgeCoDe/AgeQualiDe, AgeMooDe). Participants who completed a baseline and at least one follow-up assessment of cognitive functioning and who did not have stroke, Parkinson’s disease, atherosclerosis, kidney disease, and/or alcoholism were included in the analysis (n = 2135, 72.6% female, mean age 80.2 years). Data was collected in standardized interviews and questionnaires with the participant, a proxy informant, and the participant’s general practitioner.Results:Making three errors in the MMSE other than in the questions on orientation (MMSEwo) came with a probability of 7.8% for disorientation, making ten errors with a probability of 88.9%. A lower MMSEwo score (HR 0.75, CI 95 0.71–0.79, p < 0.001), older age (HR 1.11, CI 95 1.08–1.14, p < 0.001), and living in a nursing home (HR 1.64, CI 95 1.02–2.64, p = 0.042) were associated with incident disorientation. Impairments in walking (OR 2.41, CI 95 1.16–4.99, p = 0.018) were associated with a greater probability for prevalent disorientation. None of the life events were significant.Conclusion:Our findings suggest that disorientation is primarily associated with cognitive status. Regular walking activities might possibly reduce the risk for disorientation but further research is necessary.

AB - Background:Only little evidence is available on disorientation, one of the most challenging symptoms of Alzheimer’s disease and related dementias.Objectives:The aim of this study was to investigate the prevalence of disorientation in older age in association with the level of cognitive status, personal characteristics, and life events.Methods:Three longitudinal population-based cohort studies on cognitive health of elderly adults were harmonized (LEILA 75 + , AgeCoDe/AgeQualiDe, AgeMooDe). Participants who completed a baseline and at least one follow-up assessment of cognitive functioning and who did not have stroke, Parkinson’s disease, atherosclerosis, kidney disease, and/or alcoholism were included in the analysis (n = 2135, 72.6% female, mean age 80.2 years). Data was collected in standardized interviews and questionnaires with the participant, a proxy informant, and the participant’s general practitioner.Results:Making three errors in the MMSE other than in the questions on orientation (MMSEwo) came with a probability of 7.8% for disorientation, making ten errors with a probability of 88.9%. A lower MMSEwo score (HR 0.75, CI 95 0.71–0.79, p < 0.001), older age (HR 1.11, CI 95 1.08–1.14, p < 0.001), and living in a nursing home (HR 1.64, CI 95 1.02–2.64, p = 0.042) were associated with incident disorientation. Impairments in walking (OR 2.41, CI 95 1.16–4.99, p = 0.018) were associated with a greater probability for prevalent disorientation. None of the life events were significant.Conclusion:Our findings suggest that disorientation is primarily associated with cognitive status. Regular walking activities might possibly reduce the risk for disorientation but further research is necessary.

U2 - 10.3233/JAD-201008

DO - 10.3233/JAD-201008

M3 - SCORING: Journal article

VL - 79

SP - 1589

EP - 1599

JO - J ALZHEIMERS DIS

JF - J ALZHEIMERS DIS

SN - 1387-2877

IS - 4

ER -