Discordance in steatosis classification between liver biopsy and transient elastography for high controlled attenuation parameter (CAP) values

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Discordance in steatosis classification between liver biopsy and transient elastography for high controlled attenuation parameter (CAP) values. / Galaski, Johanna; Schulz, Lisa; Krause, Jenny; Lohse, Ansgar W.

In: Z GASTROENTEROL, Vol. 56, No. 1, 01.2018, p. 36-42.

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@article{b2f1a7d8cffa4426a056a052528bd9d0,
title = "Discordance in steatosis classification between liver biopsy and transient elastography for high controlled attenuation parameter (CAP) values",
abstract = "OBJECTIVE:  The controlled attenuation parameter (CAP) measured by transient elastography allows for the noninvasive assessment of hepatic steatosis. However, discrepant results between CAP values and histological evaluation have been reported in particular with high CAP values. We therefore investigated the diagnostic validity of high CAP measurements.METHODS:  Forty patients with liver disease and CAP measurements > 300 dB/m that underwent ultrasound-guided or minilaparoscopic liver biopsy were retrospectively enrolled. CAP values were compared with the respective histological and macroscopic evaluation and correlated with clinical parameters.RESULTS:  CAP values > 300 dB/m had an 87.5 % specificity for detection of hepatic steatosis but failed to discriminate between steatosis grade S1 - S3. Discordant results, defined as a discrepancy of at least 2 steatosis grades between transient elastography and liver biopsy, were observed in 40 % of cases. The interquartile range (IQR) of CAP was confirmed as a predictor of discrepant findings. Macroscopic evaluation as part of minilaparoscopy detected hepatic steatosis in 74 % of patients with histological grade S2 - S3 in contrast to only 10 % classified as histological grade S0 - S1.CONCLUSION:  High CAP measurements need to be interpreted with care and with regard to clinical parameters, in particular when high IQR values are registered.",
keywords = "Journal Article",
author = "Johanna Galaski and Lisa Schulz and Jenny Krause and Lohse, {Ansgar W}",
note = "{\textcopyright} Georg Thieme Verlag KG Stuttgart · New York.",
year = "2018",
month = jan,
doi = "10.1055/s-0043-123829",
language = "English",
volume = "56",
pages = "36--42",
journal = "Z GASTROENTEROL",
issn = "0044-2771",
publisher = "Karl Demeter Verlag GmbH",
number = "1",

}

RIS

TY - JOUR

T1 - Discordance in steatosis classification between liver biopsy and transient elastography for high controlled attenuation parameter (CAP) values

AU - Galaski, Johanna

AU - Schulz, Lisa

AU - Krause, Jenny

AU - Lohse, Ansgar W

N1 - © Georg Thieme Verlag KG Stuttgart · New York.

PY - 2018/1

Y1 - 2018/1

N2 - OBJECTIVE:  The controlled attenuation parameter (CAP) measured by transient elastography allows for the noninvasive assessment of hepatic steatosis. However, discrepant results between CAP values and histological evaluation have been reported in particular with high CAP values. We therefore investigated the diagnostic validity of high CAP measurements.METHODS:  Forty patients with liver disease and CAP measurements > 300 dB/m that underwent ultrasound-guided or minilaparoscopic liver biopsy were retrospectively enrolled. CAP values were compared with the respective histological and macroscopic evaluation and correlated with clinical parameters.RESULTS:  CAP values > 300 dB/m had an 87.5 % specificity for detection of hepatic steatosis but failed to discriminate between steatosis grade S1 - S3. Discordant results, defined as a discrepancy of at least 2 steatosis grades between transient elastography and liver biopsy, were observed in 40 % of cases. The interquartile range (IQR) of CAP was confirmed as a predictor of discrepant findings. Macroscopic evaluation as part of minilaparoscopy detected hepatic steatosis in 74 % of patients with histological grade S2 - S3 in contrast to only 10 % classified as histological grade S0 - S1.CONCLUSION:  High CAP measurements need to be interpreted with care and with regard to clinical parameters, in particular when high IQR values are registered.

AB - OBJECTIVE:  The controlled attenuation parameter (CAP) measured by transient elastography allows for the noninvasive assessment of hepatic steatosis. However, discrepant results between CAP values and histological evaluation have been reported in particular with high CAP values. We therefore investigated the diagnostic validity of high CAP measurements.METHODS:  Forty patients with liver disease and CAP measurements > 300 dB/m that underwent ultrasound-guided or minilaparoscopic liver biopsy were retrospectively enrolled. CAP values were compared with the respective histological and macroscopic evaluation and correlated with clinical parameters.RESULTS:  CAP values > 300 dB/m had an 87.5 % specificity for detection of hepatic steatosis but failed to discriminate between steatosis grade S1 - S3. Discordant results, defined as a discrepancy of at least 2 steatosis grades between transient elastography and liver biopsy, were observed in 40 % of cases. The interquartile range (IQR) of CAP was confirmed as a predictor of discrepant findings. Macroscopic evaluation as part of minilaparoscopy detected hepatic steatosis in 74 % of patients with histological grade S2 - S3 in contrast to only 10 % classified as histological grade S0 - S1.CONCLUSION:  High CAP measurements need to be interpreted with care and with regard to clinical parameters, in particular when high IQR values are registered.

KW - Journal Article

U2 - 10.1055/s-0043-123829

DO - 10.1055/s-0043-123829

M3 - SCORING: Journal article

C2 - 29316576

VL - 56

SP - 36

EP - 42

JO - Z GASTROENTEROL

JF - Z GASTROENTEROL

SN - 0044-2771

IS - 1

ER -