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Dinitrotoluene exposure in the copper mining industry and renal cancer: a case-cohort study

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Dinitrotoluene exposure in the copper mining industry and renal cancer: a case-cohort study. / Seidler, Andreas; Harth, Volker; Taeger, Dirk; Möhner, Matthias; Gawrych, Katarzyna; Bergmann, Annekatrin; Haerting, Johannes; Kahmann, Hans-Joachim; Bolt, Hermann Maximilian; Straif, Kurt; Brüning, Thomas.

In: OCCUP ENVIRON MED, Vol. 71, No. 4, 01.04.2014, p. 259-65.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Seidler, A, Harth, V, Taeger, D, Möhner, M, Gawrych, K, Bergmann, A, Haerting, J, Kahmann, H-J, Bolt, HM, Straif, K & Brüning, T 2014, 'Dinitrotoluene exposure in the copper mining industry and renal cancer: a case-cohort study', OCCUP ENVIRON MED, vol. 71, no. 4, pp. 259-65. https://doi.org/10.1136/oemed-2013-101850

APA

Seidler, A., Harth, V., Taeger, D., Möhner, M., Gawrych, K., Bergmann, A., Haerting, J., Kahmann, H-J., Bolt, H. M., Straif, K., & Brüning, T. (2014). Dinitrotoluene exposure in the copper mining industry and renal cancer: a case-cohort study. OCCUP ENVIRON MED, 71(4), 259-65. https://doi.org/10.1136/oemed-2013-101850

Vancouver

Seidler A, Harth V, Taeger D, Möhner M, Gawrych K, Bergmann A et al. Dinitrotoluene exposure in the copper mining industry and renal cancer: a case-cohort study. OCCUP ENVIRON MED. 2014 Apr 1;71(4):259-65. https://doi.org/10.1136/oemed-2013-101850

Bibtex

@article{ae3c44902863443f94bcb9b378bc06e0,
title = "Dinitrotoluene exposure in the copper mining industry and renal cancer: a case-cohort study",
abstract = "OBJECTIVES: To evaluate the association between dinitrotoluene (DNT) exposure and renal cancer in a case-cohort study.METHODS: This case-cohort study was conducted among men born between 1920 and 1974 (n=16 441) who were gainfully employed between 1953 and 1990 in one of two copper mines in Mansfeld, Saxony-Anhalt, former German Democratic Republic, and followed up till 31 December 2006. The study included 109 cases with renal cancer identified by record linkage with the Common Cancer Registry of the New Federal States of Germany (GKR) or by a network of pathology institutes. A comparison subcohort of 999 cohort members was selected at random from the total cohort. Duration and intensity of inhalation and dermal exposure to DNT were assessed on the basis of a job exposure matrix. A time-dependent Cox proportional hazards model modified for case-cohort design was used to assess the relationship between cumulative inhalation and dermal DNT exposure and renal cancer.RESULTS: Elevated risks were found for medium (HR=2.73; 95% CI 1.00 to 7.42) and high (HR=1.81; 95% CI 0.75 to 4.33) dermal exposure to DNT. Relative risks for medium inhalation exposure to DNT were not increased (HR=0.93; 95% CI 0.48 to 1.79) while relative risks for high inhalation exposure to DNT were elevated to 1.36 (95% CI 0.84 to 2.21). We found a statistically significant HR of 2.12 (95% CI 1.03 to 4.37) for combined medium or high inhalation and medium or high dermal exposure to DNT.CONCLUSIONS: According to our case-cohort study, dermal and inhalation exposure to DNT is associated with increased renal cancer risk.",
keywords = "Adult, Aged, Aged, 80 and over, Copper, Germany, Humans, Kidney Neoplasms, Male, Middle Aged, Mining, Occupational Diseases, Occupational Exposure, Proportional Hazards Models, Risk Factors, Toluene, Young Adult",
author = "Andreas Seidler and Volker Harth and Dirk Taeger and Matthias M{\"o}hner and Katarzyna Gawrych and Annekatrin Bergmann and Johannes Haerting and Hans-Joachim Kahmann and Bolt, {Hermann Maximilian} and Kurt Straif and Thomas Br{\"u}ning",
year = "2014",
month = apr,
day = "1",
doi = "10.1136/oemed-2013-101850",
language = "English",
volume = "71",
pages = "259--65",
journal = "OCCUP ENVIRON MED",
issn = "1351-0711",
publisher = "BMJ PUBLISHING GROUP",
number = "4",

}

RIS

TY - JOUR

T1 - Dinitrotoluene exposure in the copper mining industry and renal cancer: a case-cohort study

AU - Seidler, Andreas

AU - Harth, Volker

AU - Taeger, Dirk

AU - Möhner, Matthias

AU - Gawrych, Katarzyna

AU - Bergmann, Annekatrin

AU - Haerting, Johannes

AU - Kahmann, Hans-Joachim

AU - Bolt, Hermann Maximilian

AU - Straif, Kurt

AU - Brüning, Thomas

PY - 2014/4/1

Y1 - 2014/4/1

N2 - OBJECTIVES: To evaluate the association between dinitrotoluene (DNT) exposure and renal cancer in a case-cohort study.METHODS: This case-cohort study was conducted among men born between 1920 and 1974 (n=16 441) who were gainfully employed between 1953 and 1990 in one of two copper mines in Mansfeld, Saxony-Anhalt, former German Democratic Republic, and followed up till 31 December 2006. The study included 109 cases with renal cancer identified by record linkage with the Common Cancer Registry of the New Federal States of Germany (GKR) or by a network of pathology institutes. A comparison subcohort of 999 cohort members was selected at random from the total cohort. Duration and intensity of inhalation and dermal exposure to DNT were assessed on the basis of a job exposure matrix. A time-dependent Cox proportional hazards model modified for case-cohort design was used to assess the relationship between cumulative inhalation and dermal DNT exposure and renal cancer.RESULTS: Elevated risks were found for medium (HR=2.73; 95% CI 1.00 to 7.42) and high (HR=1.81; 95% CI 0.75 to 4.33) dermal exposure to DNT. Relative risks for medium inhalation exposure to DNT were not increased (HR=0.93; 95% CI 0.48 to 1.79) while relative risks for high inhalation exposure to DNT were elevated to 1.36 (95% CI 0.84 to 2.21). We found a statistically significant HR of 2.12 (95% CI 1.03 to 4.37) for combined medium or high inhalation and medium or high dermal exposure to DNT.CONCLUSIONS: According to our case-cohort study, dermal and inhalation exposure to DNT is associated with increased renal cancer risk.

AB - OBJECTIVES: To evaluate the association between dinitrotoluene (DNT) exposure and renal cancer in a case-cohort study.METHODS: This case-cohort study was conducted among men born between 1920 and 1974 (n=16 441) who were gainfully employed between 1953 and 1990 in one of two copper mines in Mansfeld, Saxony-Anhalt, former German Democratic Republic, and followed up till 31 December 2006. The study included 109 cases with renal cancer identified by record linkage with the Common Cancer Registry of the New Federal States of Germany (GKR) or by a network of pathology institutes. A comparison subcohort of 999 cohort members was selected at random from the total cohort. Duration and intensity of inhalation and dermal exposure to DNT were assessed on the basis of a job exposure matrix. A time-dependent Cox proportional hazards model modified for case-cohort design was used to assess the relationship between cumulative inhalation and dermal DNT exposure and renal cancer.RESULTS: Elevated risks were found for medium (HR=2.73; 95% CI 1.00 to 7.42) and high (HR=1.81; 95% CI 0.75 to 4.33) dermal exposure to DNT. Relative risks for medium inhalation exposure to DNT were not increased (HR=0.93; 95% CI 0.48 to 1.79) while relative risks for high inhalation exposure to DNT were elevated to 1.36 (95% CI 0.84 to 2.21). We found a statistically significant HR of 2.12 (95% CI 1.03 to 4.37) for combined medium or high inhalation and medium or high dermal exposure to DNT.CONCLUSIONS: According to our case-cohort study, dermal and inhalation exposure to DNT is associated with increased renal cancer risk.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Copper

KW - Germany

KW - Humans

KW - Kidney Neoplasms

KW - Male

KW - Middle Aged

KW - Mining

KW - Occupational Diseases

KW - Occupational Exposure

KW - Proportional Hazards Models

KW - Risk Factors

KW - Toluene

KW - Young Adult

U2 - 10.1136/oemed-2013-101850

DO - 10.1136/oemed-2013-101850

M3 - SCORING: Journal article

C2 - 24486554

VL - 71

SP - 259

EP - 265

JO - OCCUP ENVIRON MED

JF - OCCUP ENVIRON MED

SN - 1351-0711

IS - 4

ER -