Dinitrotoluene exposure in the copper mining industry and renal cancer: a case-cohort study
Standard
Dinitrotoluene exposure in the copper mining industry and renal cancer: a case-cohort study. / Seidler, Andreas; Harth, Volker; Taeger, Dirk; Möhner, Matthias; Gawrych, Katarzyna; Bergmann, Annekatrin; Haerting, Johannes; Kahmann, Hans-Joachim; Bolt, Hermann Maximilian; Straif, Kurt; Brüning, Thomas.
in: OCCUP ENVIRON MED, Jahrgang 71, Nr. 4, 01.04.2014, S. 259-65.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Dinitrotoluene exposure in the copper mining industry and renal cancer: a case-cohort study
AU - Seidler, Andreas
AU - Harth, Volker
AU - Taeger, Dirk
AU - Möhner, Matthias
AU - Gawrych, Katarzyna
AU - Bergmann, Annekatrin
AU - Haerting, Johannes
AU - Kahmann, Hans-Joachim
AU - Bolt, Hermann Maximilian
AU - Straif, Kurt
AU - Brüning, Thomas
PY - 2014/4/1
Y1 - 2014/4/1
N2 - OBJECTIVES: To evaluate the association between dinitrotoluene (DNT) exposure and renal cancer in a case-cohort study.METHODS: This case-cohort study was conducted among men born between 1920 and 1974 (n=16 441) who were gainfully employed between 1953 and 1990 in one of two copper mines in Mansfeld, Saxony-Anhalt, former German Democratic Republic, and followed up till 31 December 2006. The study included 109 cases with renal cancer identified by record linkage with the Common Cancer Registry of the New Federal States of Germany (GKR) or by a network of pathology institutes. A comparison subcohort of 999 cohort members was selected at random from the total cohort. Duration and intensity of inhalation and dermal exposure to DNT were assessed on the basis of a job exposure matrix. A time-dependent Cox proportional hazards model modified for case-cohort design was used to assess the relationship between cumulative inhalation and dermal DNT exposure and renal cancer.RESULTS: Elevated risks were found for medium (HR=2.73; 95% CI 1.00 to 7.42) and high (HR=1.81; 95% CI 0.75 to 4.33) dermal exposure to DNT. Relative risks for medium inhalation exposure to DNT were not increased (HR=0.93; 95% CI 0.48 to 1.79) while relative risks for high inhalation exposure to DNT were elevated to 1.36 (95% CI 0.84 to 2.21). We found a statistically significant HR of 2.12 (95% CI 1.03 to 4.37) for combined medium or high inhalation and medium or high dermal exposure to DNT.CONCLUSIONS: According to our case-cohort study, dermal and inhalation exposure to DNT is associated with increased renal cancer risk.
AB - OBJECTIVES: To evaluate the association between dinitrotoluene (DNT) exposure and renal cancer in a case-cohort study.METHODS: This case-cohort study was conducted among men born between 1920 and 1974 (n=16 441) who were gainfully employed between 1953 and 1990 in one of two copper mines in Mansfeld, Saxony-Anhalt, former German Democratic Republic, and followed up till 31 December 2006. The study included 109 cases with renal cancer identified by record linkage with the Common Cancer Registry of the New Federal States of Germany (GKR) or by a network of pathology institutes. A comparison subcohort of 999 cohort members was selected at random from the total cohort. Duration and intensity of inhalation and dermal exposure to DNT were assessed on the basis of a job exposure matrix. A time-dependent Cox proportional hazards model modified for case-cohort design was used to assess the relationship between cumulative inhalation and dermal DNT exposure and renal cancer.RESULTS: Elevated risks were found for medium (HR=2.73; 95% CI 1.00 to 7.42) and high (HR=1.81; 95% CI 0.75 to 4.33) dermal exposure to DNT. Relative risks for medium inhalation exposure to DNT were not increased (HR=0.93; 95% CI 0.48 to 1.79) while relative risks for high inhalation exposure to DNT were elevated to 1.36 (95% CI 0.84 to 2.21). We found a statistically significant HR of 2.12 (95% CI 1.03 to 4.37) for combined medium or high inhalation and medium or high dermal exposure to DNT.CONCLUSIONS: According to our case-cohort study, dermal and inhalation exposure to DNT is associated with increased renal cancer risk.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Copper
KW - Germany
KW - Humans
KW - Kidney Neoplasms
KW - Male
KW - Middle Aged
KW - Mining
KW - Occupational Diseases
KW - Occupational Exposure
KW - Proportional Hazards Models
KW - Risk Factors
KW - Toluene
KW - Young Adult
U2 - 10.1136/oemed-2013-101850
DO - 10.1136/oemed-2013-101850
M3 - SCORING: Journal article
C2 - 24486554
VL - 71
SP - 259
EP - 265
JO - OCCUP ENVIRON MED
JF - OCCUP ENVIRON MED
SN - 1351-0711
IS - 4
ER -