Die primär sklerosierende Cholangitis als Präkanzerose
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Die primär sklerosierende Cholangitis als Präkanzerose. / Schramm, C; Galle, P R.
In: Z GASTROENTEROL, Vol. 43, No. 6, 06.2005, p. 607-11.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Die primär sklerosierende Cholangitis als Präkanzerose
AU - Schramm, C
AU - Galle, P R
PY - 2005/6
Y1 - 2005/6
N2 - Primary sclerosing cholangitis is a chronic cholestatic liver disease of unknown aetiology. The course of the disease is usually progressive with the development of liver cirrhosis leading to death or liver transplantation within an average of 12 years. To date it is well known that the development of hepatobiliary malignancies and the rate of colonic mucosal dysplasia and carcinoma in patients with concomitant ulcerative colitis are greatly enhanced in patients with PSC. PSC can therefore be regarded as a premalignant condition. The following review will focus on the development of cholangiocellular carcinoma in patients with PSC and the associated diagnostic and therapeutic challenges.
AB - Primary sclerosing cholangitis is a chronic cholestatic liver disease of unknown aetiology. The course of the disease is usually progressive with the development of liver cirrhosis leading to death or liver transplantation within an average of 12 years. To date it is well known that the development of hepatobiliary malignancies and the rate of colonic mucosal dysplasia and carcinoma in patients with concomitant ulcerative colitis are greatly enhanced in patients with PSC. PSC can therefore be regarded as a premalignant condition. The following review will focus on the development of cholangiocellular carcinoma in patients with PSC and the associated diagnostic and therapeutic challenges.
KW - Biliary Tract Neoplasms
KW - Biomarkers, Tumor
KW - CA-19-9 Antigen
KW - Cholangitis, Sclerosing
KW - Humans
KW - Liver Neoplasms
KW - Precancerous Conditions
KW - Risk Assessment
KW - English Abstract
KW - Journal Article
KW - Review
U2 - 10.1055/s-2005-858311
DO - 10.1055/s-2005-858311
M3 - SCORING: Review
C2 - 15986292
VL - 43
SP - 607
EP - 611
JO - Z GASTROENTEROL
JF - Z GASTROENTEROL
SN - 0044-2771
IS - 6
ER -