Dicentric (19;21)(p13;p13), a novel chromosomal abnormality occurring in a case of Philadelphia chromosome-positive acute lymphoblastic leukemia.
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Dicentric (19;21)(p13;p13), a novel chromosomal abnormality occurring in a case of Philadelphia chromosome-positive acute lymphoblastic leukemia. / Schilling, Georgia; Dierlamm, Judith; Murga-Penas, Eva-Maria; Hinz, Kristina; Seeger, Doris; Hossfeld, Dieter Kurt.
In: CANCER GENET-NY, Vol. 152, No. 2, 2, 2004, p. 129-131.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Dicentric (19;21)(p13;p13), a novel chromosomal abnormality occurring in a case of Philadelphia chromosome-positive acute lymphoblastic leukemia.
AU - Schilling, Georgia
AU - Dierlamm, Judith
AU - Murga-Penas, Eva-Maria
AU - Hinz, Kristina
AU - Seeger, Doris
AU - Hossfeld, Dieter Kurt
PY - 2004
Y1 - 2004
N2 - We report on a patient with Philadelphia chromosome-positive acute lymphoblastic leukemia, who acquired a novel chromosomal abnormality, a dic(19;21)(p13;p13), during relapse of the disease. The cytogenetic result was confirmed by fluorescence in situ hybridization using alpha-satellite and library probes specific for chromosomes 19 and 21, respectively, as well as a chromosome 19q13.1-specific DNA probe. In our case, the dic(19;21) represents a secondary genetic change and was associated with disease progression and poor prognosis.
AB - We report on a patient with Philadelphia chromosome-positive acute lymphoblastic leukemia, who acquired a novel chromosomal abnormality, a dic(19;21)(p13;p13), during relapse of the disease. The cytogenetic result was confirmed by fluorescence in situ hybridization using alpha-satellite and library probes specific for chromosomes 19 and 21, respectively, as well as a chromosome 19q13.1-specific DNA probe. In our case, the dic(19;21) represents a secondary genetic change and was associated with disease progression and poor prognosis.
M3 - SCORING: Zeitschriftenaufsatz
VL - 152
SP - 129
EP - 131
JO - CANCER GENET-NY
JF - CANCER GENET-NY
SN - 2210-7762
IS - 2
M1 - 2
ER -