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Diadenosine phosphates and the physiological control of blood pressure

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Diadenosine phosphates and the physiological control of blood pressure. / Schlüter, H; Offers, E; Brüggemann, G; van der Giet, M; Tepel, M; Nordhoff, E; Karas, M; Spieker, C; Witzel, H; Zidek, W.

In: NATURE, Vol. 367, No. 6459, 13.01.1994, p. 186-8.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Schlüter, H, Offers, E, Brüggemann, G, van der Giet, M, Tepel, M, Nordhoff, E, Karas, M, Spieker, C, Witzel, H & Zidek, W 1994, 'Diadenosine phosphates and the physiological control of blood pressure', NATURE, vol. 367, no. 6459, pp. 186-8. https://doi.org/10.1038/367186a0

APA

Schlüter, H., Offers, E., Brüggemann, G., van der Giet, M., Tepel, M., Nordhoff, E., Karas, M., Spieker, C., Witzel, H., & Zidek, W. (1994). Diadenosine phosphates and the physiological control of blood pressure. NATURE, 367(6459), 186-8. https://doi.org/10.1038/367186a0

Vancouver

Schlüter H, Offers E, Brüggemann G, van der Giet M, Tepel M, Nordhoff E et al. Diadenosine phosphates and the physiological control of blood pressure. NATURE. 1994 Jan 13;367(6459):186-8. https://doi.org/10.1038/367186a0

Bibtex

@article{9e2a960aaa024db08cc1bbc425ee4624,
title = "Diadenosine phosphates and the physiological control of blood pressure",
abstract = "Our understanding of the regulation of vascular tone has been extended since the identification of vasoactive agents such as the atrial natriuretic peptides, endothelial-derived relaxing factor and endothelin. Unidentified vasopressive agents have been found in platelets. Here we isolate these vasopressors and identify them as diadenosine pentaphosphate (AP5A) and diadenosine hexaphosphate (AP6A) by chromatography, mass spectrometry, ultraviolet spectroscopy and enzymatic cleavage. In the vasculature of isolated perfused rat kidney, both diadenosine phosphates were active at a concentration of 10(-9) M; in aortic rings, contractions were elicited at 10(-8) M. Intra-aortic injection in the rat caused a prolonged increase in blood pressure. We conclude that AP5A and AP6A may play a part in local vasoregulation and possibly in the regulation of blood pressure.",
keywords = "5'-Nucleotidase, Alkaline Phosphatase, Animals, Aorta, Blood Platelets, Blood Pressure, Chromatography, Liquid, Dinucleoside Phosphates, Exonucleases, In Vitro Techniques, Kidney, Mass Spectrometry, Nucleotidases, Phosphodiesterase I, Phosphoric Diester Hydrolases, Rats, Spectrophotometry, Ultraviolet, Vasoconstriction, Journal Article, Research Support, Non-U.S. Gov't",
author = "H Schl{\"u}ter and E Offers and G Br{\"u}ggemann and {van der Giet}, M and M Tepel and E Nordhoff and M Karas and C Spieker and H Witzel and W Zidek",
year = "1994",
month = jan,
day = "13",
doi = "10.1038/367186a0",
language = "English",
volume = "367",
pages = "186--8",
journal = "NATURE",
issn = "0028-0836",
publisher = "NATURE PUBLISHING GROUP",
number = "6459",

}

RIS

TY - JOUR

T1 - Diadenosine phosphates and the physiological control of blood pressure

AU - Schlüter, H

AU - Offers, E

AU - Brüggemann, G

AU - van der Giet, M

AU - Tepel, M

AU - Nordhoff, E

AU - Karas, M

AU - Spieker, C

AU - Witzel, H

AU - Zidek, W

PY - 1994/1/13

Y1 - 1994/1/13

N2 - Our understanding of the regulation of vascular tone has been extended since the identification of vasoactive agents such as the atrial natriuretic peptides, endothelial-derived relaxing factor and endothelin. Unidentified vasopressive agents have been found in platelets. Here we isolate these vasopressors and identify them as diadenosine pentaphosphate (AP5A) and diadenosine hexaphosphate (AP6A) by chromatography, mass spectrometry, ultraviolet spectroscopy and enzymatic cleavage. In the vasculature of isolated perfused rat kidney, both diadenosine phosphates were active at a concentration of 10(-9) M; in aortic rings, contractions were elicited at 10(-8) M. Intra-aortic injection in the rat caused a prolonged increase in blood pressure. We conclude that AP5A and AP6A may play a part in local vasoregulation and possibly in the regulation of blood pressure.

AB - Our understanding of the regulation of vascular tone has been extended since the identification of vasoactive agents such as the atrial natriuretic peptides, endothelial-derived relaxing factor and endothelin. Unidentified vasopressive agents have been found in platelets. Here we isolate these vasopressors and identify them as diadenosine pentaphosphate (AP5A) and diadenosine hexaphosphate (AP6A) by chromatography, mass spectrometry, ultraviolet spectroscopy and enzymatic cleavage. In the vasculature of isolated perfused rat kidney, both diadenosine phosphates were active at a concentration of 10(-9) M; in aortic rings, contractions were elicited at 10(-8) M. Intra-aortic injection in the rat caused a prolonged increase in blood pressure. We conclude that AP5A and AP6A may play a part in local vasoregulation and possibly in the regulation of blood pressure.

KW - 5'-Nucleotidase

KW - Alkaline Phosphatase

KW - Animals

KW - Aorta

KW - Blood Platelets

KW - Blood Pressure

KW - Chromatography, Liquid

KW - Dinucleoside Phosphates

KW - Exonucleases

KW - In Vitro Techniques

KW - Kidney

KW - Mass Spectrometry

KW - Nucleotidases

KW - Phosphodiesterase I

KW - Phosphoric Diester Hydrolases

KW - Rats

KW - Spectrophotometry, Ultraviolet

KW - Vasoconstriction

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1038/367186a0

DO - 10.1038/367186a0

M3 - SCORING: Journal article

C2 - 8114917

VL - 367

SP - 186

EP - 188

JO - NATURE

JF - NATURE

SN - 0028-0836

IS - 6459

ER -