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Developmental origin and sex-specific risk for infections and immune diseases later in life

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Developmental origin and sex-specific risk for infections and immune diseases later in life. / Zazara, Dimitra E; Arck, Petra Clara.

In: SEMIN IMMUNOPATHOL, Vol. 41, No. 2, 01.03.2019, p. 137-151.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Zazara, DE & Arck, PC 2019, 'Developmental origin and sex-specific risk for infections and immune diseases later in life', SEMIN IMMUNOPATHOL, vol. 41, no. 2, pp. 137-151. https://doi.org/10.1007/s00281-018-0713-x

APA

Zazara, D. E., & Arck, P. C. (2019). Developmental origin and sex-specific risk for infections and immune diseases later in life. SEMIN IMMUNOPATHOL, 41(2), 137-151. https://doi.org/10.1007/s00281-018-0713-x

Vancouver

Zazara DE, Arck PC. Developmental origin and sex-specific risk for infections and immune diseases later in life. SEMIN IMMUNOPATHOL. 2019 Mar 1;41(2):137-151. https://doi.org/10.1007/s00281-018-0713-x

Bibtex

@article{045e84d556084474be0b76b836b1ec31,
title = "Developmental origin and sex-specific risk for infections and immune diseases later in life",
abstract = "The intrauterine environment is an important determinant of immunity later in life of the offspring. An altered prenatal immune development can result in a high postnatal risk for infections, chronic immune diseases, and autoimmunity. Many of these immune diseases show a strong sex bias, such as a high incidence of autoimmune diseases and allergies in adult females or a high risk for infections in males. Here, we comprehensively review established pathways and propose novel concepts modulating the risk for such poor immunity during childhood and throughout life. Moreover, we highlight how an adverse fetal environment may affect or aggravate the risk for poor immunity in a sex-specific manner. An improved understanding of a sex-specific susceptibility to poor immunity along with insights on how such risk can be modulated before or around birth will allow the development of tailored prevention strategies.",
keywords = "Journal Article, Review",
author = "Zazara, {Dimitra E} and Arck, {Petra Clara}",
year = "2019",
month = mar,
day = "1",
doi = "10.1007/s00281-018-0713-x",
language = "English",
volume = "41",
pages = "137--151",
journal = "SEMIN IMMUNOPATHOL",
issn = "1863-2297",
publisher = "Springer",
number = "2",

}

RIS

TY - JOUR

T1 - Developmental origin and sex-specific risk for infections and immune diseases later in life

AU - Zazara, Dimitra E

AU - Arck, Petra Clara

PY - 2019/3/1

Y1 - 2019/3/1

N2 - The intrauterine environment is an important determinant of immunity later in life of the offspring. An altered prenatal immune development can result in a high postnatal risk for infections, chronic immune diseases, and autoimmunity. Many of these immune diseases show a strong sex bias, such as a high incidence of autoimmune diseases and allergies in adult females or a high risk for infections in males. Here, we comprehensively review established pathways and propose novel concepts modulating the risk for such poor immunity during childhood and throughout life. Moreover, we highlight how an adverse fetal environment may affect or aggravate the risk for poor immunity in a sex-specific manner. An improved understanding of a sex-specific susceptibility to poor immunity along with insights on how such risk can be modulated before or around birth will allow the development of tailored prevention strategies.

AB - The intrauterine environment is an important determinant of immunity later in life of the offspring. An altered prenatal immune development can result in a high postnatal risk for infections, chronic immune diseases, and autoimmunity. Many of these immune diseases show a strong sex bias, such as a high incidence of autoimmune diseases and allergies in adult females or a high risk for infections in males. Here, we comprehensively review established pathways and propose novel concepts modulating the risk for such poor immunity during childhood and throughout life. Moreover, we highlight how an adverse fetal environment may affect or aggravate the risk for poor immunity in a sex-specific manner. An improved understanding of a sex-specific susceptibility to poor immunity along with insights on how such risk can be modulated before or around birth will allow the development of tailored prevention strategies.

KW - Journal Article

KW - Review

U2 - 10.1007/s00281-018-0713-x

DO - 10.1007/s00281-018-0713-x

M3 - SCORING: Review article

C2 - 30298432

VL - 41

SP - 137

EP - 151

JO - SEMIN IMMUNOPATHOL

JF - SEMIN IMMUNOPATHOL

SN - 1863-2297

IS - 2

ER -