Developmental origin and sex-specific risk for infections and immune diseases later in life
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Developmental origin and sex-specific risk for infections and immune diseases later in life. / Zazara, Dimitra E; Arck, Petra Clara.
in: SEMIN IMMUNOPATHOL, Jahrgang 41, Nr. 2, 01.03.2019, S. 137-151.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Developmental origin and sex-specific risk for infections and immune diseases later in life
AU - Zazara, Dimitra E
AU - Arck, Petra Clara
PY - 2019/3/1
Y1 - 2019/3/1
N2 - The intrauterine environment is an important determinant of immunity later in life of the offspring. An altered prenatal immune development can result in a high postnatal risk for infections, chronic immune diseases, and autoimmunity. Many of these immune diseases show a strong sex bias, such as a high incidence of autoimmune diseases and allergies in adult females or a high risk for infections in males. Here, we comprehensively review established pathways and propose novel concepts modulating the risk for such poor immunity during childhood and throughout life. Moreover, we highlight how an adverse fetal environment may affect or aggravate the risk for poor immunity in a sex-specific manner. An improved understanding of a sex-specific susceptibility to poor immunity along with insights on how such risk can be modulated before or around birth will allow the development of tailored prevention strategies.
AB - The intrauterine environment is an important determinant of immunity later in life of the offspring. An altered prenatal immune development can result in a high postnatal risk for infections, chronic immune diseases, and autoimmunity. Many of these immune diseases show a strong sex bias, such as a high incidence of autoimmune diseases and allergies in adult females or a high risk for infections in males. Here, we comprehensively review established pathways and propose novel concepts modulating the risk for such poor immunity during childhood and throughout life. Moreover, we highlight how an adverse fetal environment may affect or aggravate the risk for poor immunity in a sex-specific manner. An improved understanding of a sex-specific susceptibility to poor immunity along with insights on how such risk can be modulated before or around birth will allow the development of tailored prevention strategies.
KW - Journal Article
KW - Review
U2 - 10.1007/s00281-018-0713-x
DO - 10.1007/s00281-018-0713-x
M3 - SCORING: Review article
C2 - 30298432
VL - 41
SP - 137
EP - 151
JO - SEMIN IMMUNOPATHOL
JF - SEMIN IMMUNOPATHOL
SN - 1863-2297
IS - 2
ER -