Developmental changes in the L-arginine/nitric oxide pathway from infancy to adulthood: plasma asymmetric dimethylarginine levels decrease with age.
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Developmental changes in the L-arginine/nitric oxide pathway from infancy to adulthood: plasma asymmetric dimethylarginine levels decrease with age. / Lücke, Thomas; Kanzelmeyer, Nele; Kemper, Markus J.; Tsikas, Dimitrios; Das, Anibh M.
In: CLIN CHEM LAB MED, Vol. 45, No. 11, 11, 2007, p. 1525-1530.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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T1 - Developmental changes in the L-arginine/nitric oxide pathway from infancy to adulthood: plasma asymmetric dimethylarginine levels decrease with age.
AU - Lücke, Thomas
AU - Kanzelmeyer, Nele
AU - Kemper, Markus J.
AU - Tsikas, Dimitrios
AU - Das, Anibh M
PY - 2007
Y1 - 2007
N2 - BACKGROUND: The L-arginine/nitric oxide (NO) pathway has multiple physiological functions including vasodilation, inhibition of platelet aggregation and neurotransmission. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of all known NO synthase isoforms, has adverse effects on renal and cardiovascular function in adults. It is unknown whether ADMA might also exert similar effects in younger individuals including infants. Also, reference data for important members of the L-arginine/NO family, notably ADMA and the NO metabolites, nitrite and nitrate, in infancy are lacking. METHODS: In the present study, we investigated the status of the L-arginine/NO pathway in 34 healthy volunteers aged 2 days to 24 years by measuring the concentration of ADMA, nitrite, nitrate and L-arginine in plasma and urine using gas chromatography-mass spectrometry and gas chromatography-tandem mass spectrometry methods. RESULTS: We found that ADMA levels in plasma decreased with age (Pearson correlation coefficient r=-0.619, p
AB - BACKGROUND: The L-arginine/nitric oxide (NO) pathway has multiple physiological functions including vasodilation, inhibition of platelet aggregation and neurotransmission. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of all known NO synthase isoforms, has adverse effects on renal and cardiovascular function in adults. It is unknown whether ADMA might also exert similar effects in younger individuals including infants. Also, reference data for important members of the L-arginine/NO family, notably ADMA and the NO metabolites, nitrite and nitrate, in infancy are lacking. METHODS: In the present study, we investigated the status of the L-arginine/NO pathway in 34 healthy volunteers aged 2 days to 24 years by measuring the concentration of ADMA, nitrite, nitrate and L-arginine in plasma and urine using gas chromatography-mass spectrometry and gas chromatography-tandem mass spectrometry methods. RESULTS: We found that ADMA levels in plasma decreased with age (Pearson correlation coefficient r=-0.619, p
M3 - SCORING: Zeitschriftenaufsatz
VL - 45
SP - 1525
EP - 1530
JO - CLIN CHEM LAB MED
JF - CLIN CHEM LAB MED
SN - 1434-6621
IS - 11
M1 - 11
ER -
