Development of long circulating magnetic particle imaging tracers: use of novel magnetic nanoparticles and entrapment into human erythrocytes
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Development of long circulating magnetic particle imaging tracers: use of novel magnetic nanoparticles and entrapment into human erythrocytes. / Antonelli, Antonella; Szwargulski, Patryk; Scarpa, Emanuele-Salvatore; Thieben, Florian; Cordula, Grüttner; Ambrosi, Gianluca; Guidi, Loretta; Ludewig, Peter; Knopp, Tobias; Magnani, Mauro.
In: NANOMEDICINE-UK, Vol. 15, No. 8, 04.2020, p. 739-753.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Development of long circulating magnetic particle imaging tracers: use of novel magnetic nanoparticles and entrapment into human erythrocytes
AU - Antonelli, Antonella
AU - Szwargulski, Patryk
AU - Scarpa, Emanuele-Salvatore
AU - Thieben, Florian
AU - Cordula, Grüttner
AU - Ambrosi, Gianluca
AU - Guidi, Loretta
AU - Ludewig, Peter
AU - Knopp, Tobias
AU - Magnani, Mauro
PY - 2020/4
Y1 - 2020/4
N2 - Aim: Magnetic particle imaging (MPI) is highly promising for biomedical applications, but optimal tracers for MPI, namely superparamagnetic iron oxide-based contrast agents, are still lacking. Materials & methods: The encapsulation of commercially available nanoparticles, specifically synomag®-D and perimag®, into human red blood cells (RBCs) was performed by a hypotonic dialysis and isotonic resealing procedure. The amounts of superparamagnetic iron oxide incorporated into RBCs were determined by Fe quantification using nuclear magnetic resonance and magnetic particle spectroscopy. Results: Perimag-COOH nanoparticles were identified as the best nanomaterial for encapsulation in RBCs. Perimag-COOH-loaded RBCs proved to be viable cells showing a good magnetic particle spectroscopy performance, while the magnetic signal of synomag-D-COOH-loaded RBCs dropped sharply. Conclusion: Perimag-COOH-loaded RBCs could be a potential tool for MPI diagnostic applications.
AB - Aim: Magnetic particle imaging (MPI) is highly promising for biomedical applications, but optimal tracers for MPI, namely superparamagnetic iron oxide-based contrast agents, are still lacking. Materials & methods: The encapsulation of commercially available nanoparticles, specifically synomag®-D and perimag®, into human red blood cells (RBCs) was performed by a hypotonic dialysis and isotonic resealing procedure. The amounts of superparamagnetic iron oxide incorporated into RBCs were determined by Fe quantification using nuclear magnetic resonance and magnetic particle spectroscopy. Results: Perimag-COOH nanoparticles were identified as the best nanomaterial for encapsulation in RBCs. Perimag-COOH-loaded RBCs proved to be viable cells showing a good magnetic particle spectroscopy performance, while the magnetic signal of synomag-D-COOH-loaded RBCs dropped sharply. Conclusion: Perimag-COOH-loaded RBCs could be a potential tool for MPI diagnostic applications.
U2 - 10.2217/nnm-2019-0449
DO - 10.2217/nnm-2019-0449
M3 - SCORING: Journal article
C2 - 32207374
VL - 15
SP - 739
EP - 753
JO - NANOMEDICINE-UK
JF - NANOMEDICINE-UK
SN - 1743-5889
IS - 8
ER -