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Development of long circulating magnetic particle imaging tracers: use of novel magnetic nanoparticles and entrapment into human erythrocytes

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Development of long circulating magnetic particle imaging tracers: use of novel magnetic nanoparticles and entrapment into human erythrocytes. / Antonelli, Antonella; Szwargulski, Patryk; Scarpa, Emanuele-Salvatore; Thieben, Florian; Cordula, Grüttner; Ambrosi, Gianluca; Guidi, Loretta; Ludewig, Peter; Knopp, Tobias; Magnani, Mauro.

in: NANOMEDICINE-UK, Jahrgang 15, Nr. 8, 04.2020, S. 739-753.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Antonelli, A, Szwargulski, P, Scarpa, E-S, Thieben, F, Cordula, G, Ambrosi, G, Guidi, L, Ludewig, P, Knopp, T & Magnani, M 2020, 'Development of long circulating magnetic particle imaging tracers: use of novel magnetic nanoparticles and entrapment into human erythrocytes', NANOMEDICINE-UK, Jg. 15, Nr. 8, S. 739-753. https://doi.org/10.2217/nnm-2019-0449

APA

Antonelli, A., Szwargulski, P., Scarpa, E-S., Thieben, F., Cordula, G., Ambrosi, G., Guidi, L., Ludewig, P., Knopp, T., & Magnani, M. (2020). Development of long circulating magnetic particle imaging tracers: use of novel magnetic nanoparticles and entrapment into human erythrocytes. NANOMEDICINE-UK, 15(8), 739-753. https://doi.org/10.2217/nnm-2019-0449

Vancouver

Antonelli A, Szwargulski P, Scarpa E-S, Thieben F, Cordula G, Ambrosi G et al. Development of long circulating magnetic particle imaging tracers: use of novel magnetic nanoparticles and entrapment into human erythrocytes. NANOMEDICINE-UK. 2020 Apr;15(8):739-753. https://doi.org/10.2217/nnm-2019-0449

Bibtex

@article{afb868004b164d068058f2d3dd25006d,
title = "Development of long circulating magnetic particle imaging tracers: use of novel magnetic nanoparticles and entrapment into human erythrocytes",
abstract = "Aim: Magnetic particle imaging (MPI) is highly promising for biomedical applications, but optimal tracers for MPI, namely superparamagnetic iron oxide-based contrast agents, are still lacking. Materials & methods: The encapsulation of commercially available nanoparticles, specifically synomag{\textregistered}-D and perimag{\textregistered}, into human red blood cells (RBCs) was performed by a hypotonic dialysis and isotonic resealing procedure. The amounts of superparamagnetic iron oxide incorporated into RBCs were determined by Fe quantification using nuclear magnetic resonance and magnetic particle spectroscopy. Results: Perimag-COOH nanoparticles were identified as the best nanomaterial for encapsulation in RBCs. Perimag-COOH-loaded RBCs proved to be viable cells showing a good magnetic particle spectroscopy performance, while the magnetic signal of synomag-D-COOH-loaded RBCs dropped sharply. Conclusion: Perimag-COOH-loaded RBCs could be a potential tool for MPI diagnostic applications.",
author = "Antonella Antonelli and Patryk Szwargulski and Emanuele-Salvatore Scarpa and Florian Thieben and Gr{\"u}ttner Cordula and Gianluca Ambrosi and Loretta Guidi and Peter Ludewig and Tobias Knopp and Mauro Magnani",
year = "2020",
month = apr,
doi = "10.2217/nnm-2019-0449",
language = "English",
volume = "15",
pages = "739--753",
journal = "NANOMEDICINE-UK",
issn = "1743-5889",
publisher = "Future Medicine Ltd",
number = "8",

}

RIS

TY - JOUR

T1 - Development of long circulating magnetic particle imaging tracers: use of novel magnetic nanoparticles and entrapment into human erythrocytes

AU - Antonelli, Antonella

AU - Szwargulski, Patryk

AU - Scarpa, Emanuele-Salvatore

AU - Thieben, Florian

AU - Cordula, Grüttner

AU - Ambrosi, Gianluca

AU - Guidi, Loretta

AU - Ludewig, Peter

AU - Knopp, Tobias

AU - Magnani, Mauro

PY - 2020/4

Y1 - 2020/4

N2 - Aim: Magnetic particle imaging (MPI) is highly promising for biomedical applications, but optimal tracers for MPI, namely superparamagnetic iron oxide-based contrast agents, are still lacking. Materials & methods: The encapsulation of commercially available nanoparticles, specifically synomag®-D and perimag®, into human red blood cells (RBCs) was performed by a hypotonic dialysis and isotonic resealing procedure. The amounts of superparamagnetic iron oxide incorporated into RBCs were determined by Fe quantification using nuclear magnetic resonance and magnetic particle spectroscopy. Results: Perimag-COOH nanoparticles were identified as the best nanomaterial for encapsulation in RBCs. Perimag-COOH-loaded RBCs proved to be viable cells showing a good magnetic particle spectroscopy performance, while the magnetic signal of synomag-D-COOH-loaded RBCs dropped sharply. Conclusion: Perimag-COOH-loaded RBCs could be a potential tool for MPI diagnostic applications.

AB - Aim: Magnetic particle imaging (MPI) is highly promising for biomedical applications, but optimal tracers for MPI, namely superparamagnetic iron oxide-based contrast agents, are still lacking. Materials & methods: The encapsulation of commercially available nanoparticles, specifically synomag®-D and perimag®, into human red blood cells (RBCs) was performed by a hypotonic dialysis and isotonic resealing procedure. The amounts of superparamagnetic iron oxide incorporated into RBCs were determined by Fe quantification using nuclear magnetic resonance and magnetic particle spectroscopy. Results: Perimag-COOH nanoparticles were identified as the best nanomaterial for encapsulation in RBCs. Perimag-COOH-loaded RBCs proved to be viable cells showing a good magnetic particle spectroscopy performance, while the magnetic signal of synomag-D-COOH-loaded RBCs dropped sharply. Conclusion: Perimag-COOH-loaded RBCs could be a potential tool for MPI diagnostic applications.

U2 - 10.2217/nnm-2019-0449

DO - 10.2217/nnm-2019-0449

M3 - SCORING: Journal article

C2 - 32207374

VL - 15

SP - 739

EP - 753

JO - NANOMEDICINE-UK

JF - NANOMEDICINE-UK

SN - 1743-5889

IS - 8

ER -