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Determinants of change in quality of life in the Cardiac Insufficiency Bisoprolol Study in Elderly (CIBIS-ELD)

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Determinants of change in quality of life in the Cardiac Insufficiency Bisoprolol Study in Elderly (CIBIS-ELD). / Scherer, Martin; Düngen, Hans-Dirk; Inkrot, Simone; Tahirović, Elvis; Lashki, Diana Jahandar; Apostolović, Svetlana; Edelmann, Frank; Wachter, Rolf; Loncar, Goran; Haverkamp, Wilhelm; Neskovic, Aleksandar; Herrmann-Lingen, Christoph.

In: EUR J INTERN MED, Vol. 24, No. 4, 01.06.2013, p. 333-8.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Scherer, M, Düngen, H-D, Inkrot, S, Tahirović, E, Lashki, DJ, Apostolović, S, Edelmann, F, Wachter, R, Loncar, G, Haverkamp, W, Neskovic, A & Herrmann-Lingen, C 2013, 'Determinants of change in quality of life in the Cardiac Insufficiency Bisoprolol Study in Elderly (CIBIS-ELD)', EUR J INTERN MED, vol. 24, no. 4, pp. 333-8. https://doi.org/10.1016/j.ejim.2013.01.003

APA

Scherer, M., Düngen, H-D., Inkrot, S., Tahirović, E., Lashki, D. J., Apostolović, S., Edelmann, F., Wachter, R., Loncar, G., Haverkamp, W., Neskovic, A., & Herrmann-Lingen, C. (2013). Determinants of change in quality of life in the Cardiac Insufficiency Bisoprolol Study in Elderly (CIBIS-ELD). EUR J INTERN MED, 24(4), 333-8. https://doi.org/10.1016/j.ejim.2013.01.003

Vancouver

Scherer M, Düngen H-D, Inkrot S, Tahirović E, Lashki DJ, Apostolović S et al. Determinants of change in quality of life in the Cardiac Insufficiency Bisoprolol Study in Elderly (CIBIS-ELD). EUR J INTERN MED. 2013 Jun 1;24(4):333-8. https://doi.org/10.1016/j.ejim.2013.01.003

Bibtex

@article{d4294dbc22424c3582a038ca87fd24b6,
title = "Determinants of change in quality of life in the Cardiac Insufficiency Bisoprolol Study in Elderly (CIBIS-ELD)",
abstract = "OBJECTIVE: Little is known about parameters that lead to improvement in QoL in individual patients. We analysed the data of the Cardiac Insufficiency Bisoprolol Study in Elderly (CIBIS-ELD) in order to answer the question of how and to what extent change in health-related QoL during up-titration with bisoprolol vs. carvedilol is influenced by clinical and psychosocial factors in elderly patients with heart failure.METHODS: This is a QoL analysis of CIBIS-ELD, an investigator-initiated multi-center randomised phase III trial in elderly patients (65 years or older) with moderate to severe heart failure. Clinical parameters such as New York Heart Association functional class, heart rate, left ventricular ejection fraction (LVEF), 6-min walk distance, as well as the physical and psychosocial component scores on the short-form QoL health survey (SF36) and depression were recorded at baseline and at the final study visit.RESULTS: Full baseline and follow-up QoL data were available for 589 patients (292 in the bisoprolol and 297 in the carvedilol group). Mean physical and psychosocial QoL improved significantly during treatment. In regression analyses, changes in both SF36 component scores from baseline to follow-up were mainly predicted by baseline QoL and depression as well as change in depression over time. Changes in cardiac severity markers were significantly weaker predictors.CONCLUSION: Mean QoL increased during up-titration of bisoprolol and carvedilol. Both baseline depression and improvement in depression over time are associated with greater improvement in QoL more strongly than changes in cardiac severity measures.",
keywords = "Adrenergic beta-1 Receptor Antagonists, Aged, Aged, 80 and over, Bisoprolol, Carbazoles, Depression, Female, Heart Failure, Humans, Linear Models, Male, Propanolamines, Quality of Life, Questionnaires, Treatment Outcome",
author = "Martin Scherer and Hans-Dirk D{\"u}ngen and Simone Inkrot and Elvis Tahirovi{\'c} and Lashki, {Diana Jahandar} and Svetlana Apostolovi{\'c} and Frank Edelmann and Rolf Wachter and Goran Loncar and Wilhelm Haverkamp and Aleksandar Neskovic and Christoph Herrmann-Lingen",
note = "Copyright {\textcopyright} 2013 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.",
year = "2013",
month = jun,
day = "1",
doi = "10.1016/j.ejim.2013.01.003",
language = "English",
volume = "24",
pages = "333--8",
journal = "EUR J INTERN MED",
issn = "0953-6205",
publisher = "ELSEVIER SCIENCE BV",
number = "4",

}

RIS

TY - JOUR

T1 - Determinants of change in quality of life in the Cardiac Insufficiency Bisoprolol Study in Elderly (CIBIS-ELD)

AU - Scherer, Martin

AU - Düngen, Hans-Dirk

AU - Inkrot, Simone

AU - Tahirović, Elvis

AU - Lashki, Diana Jahandar

AU - Apostolović, Svetlana

AU - Edelmann, Frank

AU - Wachter, Rolf

AU - Loncar, Goran

AU - Haverkamp, Wilhelm

AU - Neskovic, Aleksandar

AU - Herrmann-Lingen, Christoph

N1 - Copyright © 2013 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

PY - 2013/6/1

Y1 - 2013/6/1

N2 - OBJECTIVE: Little is known about parameters that lead to improvement in QoL in individual patients. We analysed the data of the Cardiac Insufficiency Bisoprolol Study in Elderly (CIBIS-ELD) in order to answer the question of how and to what extent change in health-related QoL during up-titration with bisoprolol vs. carvedilol is influenced by clinical and psychosocial factors in elderly patients with heart failure.METHODS: This is a QoL analysis of CIBIS-ELD, an investigator-initiated multi-center randomised phase III trial in elderly patients (65 years or older) with moderate to severe heart failure. Clinical parameters such as New York Heart Association functional class, heart rate, left ventricular ejection fraction (LVEF), 6-min walk distance, as well as the physical and psychosocial component scores on the short-form QoL health survey (SF36) and depression were recorded at baseline and at the final study visit.RESULTS: Full baseline and follow-up QoL data were available for 589 patients (292 in the bisoprolol and 297 in the carvedilol group). Mean physical and psychosocial QoL improved significantly during treatment. In regression analyses, changes in both SF36 component scores from baseline to follow-up were mainly predicted by baseline QoL and depression as well as change in depression over time. Changes in cardiac severity markers were significantly weaker predictors.CONCLUSION: Mean QoL increased during up-titration of bisoprolol and carvedilol. Both baseline depression and improvement in depression over time are associated with greater improvement in QoL more strongly than changes in cardiac severity measures.

AB - OBJECTIVE: Little is known about parameters that lead to improvement in QoL in individual patients. We analysed the data of the Cardiac Insufficiency Bisoprolol Study in Elderly (CIBIS-ELD) in order to answer the question of how and to what extent change in health-related QoL during up-titration with bisoprolol vs. carvedilol is influenced by clinical and psychosocial factors in elderly patients with heart failure.METHODS: This is a QoL analysis of CIBIS-ELD, an investigator-initiated multi-center randomised phase III trial in elderly patients (65 years or older) with moderate to severe heart failure. Clinical parameters such as New York Heart Association functional class, heart rate, left ventricular ejection fraction (LVEF), 6-min walk distance, as well as the physical and psychosocial component scores on the short-form QoL health survey (SF36) and depression were recorded at baseline and at the final study visit.RESULTS: Full baseline and follow-up QoL data were available for 589 patients (292 in the bisoprolol and 297 in the carvedilol group). Mean physical and psychosocial QoL improved significantly during treatment. In regression analyses, changes in both SF36 component scores from baseline to follow-up were mainly predicted by baseline QoL and depression as well as change in depression over time. Changes in cardiac severity markers were significantly weaker predictors.CONCLUSION: Mean QoL increased during up-titration of bisoprolol and carvedilol. Both baseline depression and improvement in depression over time are associated with greater improvement in QoL more strongly than changes in cardiac severity measures.

KW - Adrenergic beta-1 Receptor Antagonists

KW - Aged

KW - Aged, 80 and over

KW - Bisoprolol

KW - Carbazoles

KW - Depression

KW - Female

KW - Heart Failure

KW - Humans

KW - Linear Models

KW - Male

KW - Propanolamines

KW - Quality of Life

KW - Questionnaires

KW - Treatment Outcome

U2 - 10.1016/j.ejim.2013.01.003

DO - 10.1016/j.ejim.2013.01.003

M3 - SCORING: Journal article

C2 - 23375618

VL - 24

SP - 333

EP - 338

JO - EUR J INTERN MED

JF - EUR J INTERN MED

SN - 0953-6205

IS - 4

ER -