Determinants of change in quality of life in the Cardiac Insufficiency Bisoprolol Study in Elderly (CIBIS-ELD)
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Determinants of change in quality of life in the Cardiac Insufficiency Bisoprolol Study in Elderly (CIBIS-ELD). / Scherer, Martin; Düngen, Hans-Dirk; Inkrot, Simone; Tahirović, Elvis; Lashki, Diana Jahandar; Apostolović, Svetlana; Edelmann, Frank; Wachter, Rolf; Loncar, Goran; Haverkamp, Wilhelm; Neskovic, Aleksandar; Herrmann-Lingen, Christoph.
in: EUR J INTERN MED, Jahrgang 24, Nr. 4, 01.06.2013, S. 333-8.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Determinants of change in quality of life in the Cardiac Insufficiency Bisoprolol Study in Elderly (CIBIS-ELD)
AU - Scherer, Martin
AU - Düngen, Hans-Dirk
AU - Inkrot, Simone
AU - Tahirović, Elvis
AU - Lashki, Diana Jahandar
AU - Apostolović, Svetlana
AU - Edelmann, Frank
AU - Wachter, Rolf
AU - Loncar, Goran
AU - Haverkamp, Wilhelm
AU - Neskovic, Aleksandar
AU - Herrmann-Lingen, Christoph
N1 - Copyright © 2013 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
PY - 2013/6/1
Y1 - 2013/6/1
N2 - OBJECTIVE: Little is known about parameters that lead to improvement in QoL in individual patients. We analysed the data of the Cardiac Insufficiency Bisoprolol Study in Elderly (CIBIS-ELD) in order to answer the question of how and to what extent change in health-related QoL during up-titration with bisoprolol vs. carvedilol is influenced by clinical and psychosocial factors in elderly patients with heart failure.METHODS: This is a QoL analysis of CIBIS-ELD, an investigator-initiated multi-center randomised phase III trial in elderly patients (65 years or older) with moderate to severe heart failure. Clinical parameters such as New York Heart Association functional class, heart rate, left ventricular ejection fraction (LVEF), 6-min walk distance, as well as the physical and psychosocial component scores on the short-form QoL health survey (SF36) and depression were recorded at baseline and at the final study visit.RESULTS: Full baseline and follow-up QoL data were available for 589 patients (292 in the bisoprolol and 297 in the carvedilol group). Mean physical and psychosocial QoL improved significantly during treatment. In regression analyses, changes in both SF36 component scores from baseline to follow-up were mainly predicted by baseline QoL and depression as well as change in depression over time. Changes in cardiac severity markers were significantly weaker predictors.CONCLUSION: Mean QoL increased during up-titration of bisoprolol and carvedilol. Both baseline depression and improvement in depression over time are associated with greater improvement in QoL more strongly than changes in cardiac severity measures.
AB - OBJECTIVE: Little is known about parameters that lead to improvement in QoL in individual patients. We analysed the data of the Cardiac Insufficiency Bisoprolol Study in Elderly (CIBIS-ELD) in order to answer the question of how and to what extent change in health-related QoL during up-titration with bisoprolol vs. carvedilol is influenced by clinical and psychosocial factors in elderly patients with heart failure.METHODS: This is a QoL analysis of CIBIS-ELD, an investigator-initiated multi-center randomised phase III trial in elderly patients (65 years or older) with moderate to severe heart failure. Clinical parameters such as New York Heart Association functional class, heart rate, left ventricular ejection fraction (LVEF), 6-min walk distance, as well as the physical and psychosocial component scores on the short-form QoL health survey (SF36) and depression were recorded at baseline and at the final study visit.RESULTS: Full baseline and follow-up QoL data were available for 589 patients (292 in the bisoprolol and 297 in the carvedilol group). Mean physical and psychosocial QoL improved significantly during treatment. In regression analyses, changes in both SF36 component scores from baseline to follow-up were mainly predicted by baseline QoL and depression as well as change in depression over time. Changes in cardiac severity markers were significantly weaker predictors.CONCLUSION: Mean QoL increased during up-titration of bisoprolol and carvedilol. Both baseline depression and improvement in depression over time are associated with greater improvement in QoL more strongly than changes in cardiac severity measures.
KW - Adrenergic beta-1 Receptor Antagonists
KW - Aged
KW - Aged, 80 and over
KW - Bisoprolol
KW - Carbazoles
KW - Depression
KW - Female
KW - Heart Failure
KW - Humans
KW - Linear Models
KW - Male
KW - Propanolamines
KW - Quality of Life
KW - Questionnaires
KW - Treatment Outcome
U2 - 10.1016/j.ejim.2013.01.003
DO - 10.1016/j.ejim.2013.01.003
M3 - SCORING: Journal article
C2 - 23375618
VL - 24
SP - 333
EP - 338
JO - EUR J INTERN MED
JF - EUR J INTERN MED
SN - 0953-6205
IS - 4
ER -