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Detection of microscopic diffusion anisotropy on a whole-body MR system with double wave vector imaging.

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Detection of microscopic diffusion anisotropy on a whole-body MR system with double wave vector imaging. / Lawrenz, Marco; Finsterbusch, Jürgen.

In: MAGN RESON MED, Vol. 66, No. 5, 5, 2011, p. 1405-1415.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Lawrenz, M & Finsterbusch, J 2011, 'Detection of microscopic diffusion anisotropy on a whole-body MR system with double wave vector imaging.', MAGN RESON MED, vol. 66, no. 5, 5, pp. 1405-1415. <http://www.ncbi.nlm.nih.gov/pubmed/21488098?dopt=Citation>

APA

Lawrenz, M., & Finsterbusch, J. (2011). Detection of microscopic diffusion anisotropy on a whole-body MR system with double wave vector imaging. MAGN RESON MED, 66(5), 1405-1415. [5]. http://www.ncbi.nlm.nih.gov/pubmed/21488098?dopt=Citation

Vancouver

Lawrenz M, Finsterbusch J. Detection of microscopic diffusion anisotropy on a whole-body MR system with double wave vector imaging. MAGN RESON MED. 2011;66(5):1405-1415. 5.

Bibtex

@article{2c35fbdbd396484aa60b2d193452dd01,
title = "Detection of microscopic diffusion anisotropy on a whole-body MR system with double wave vector imaging.",
abstract = "Double-wave-vector diffusion-weighting experiments can detect diffusion anisotropy on a microscopic level which, e.g., could distinguish lower fiber densities from reduced fiber coherence. The underlying signal difference between parallel and orthogonal wave vector orientations has been observed on vertical-bore MR systems (?500 mT m(-1) ); however, numerical simulations reveal that it is expected to be considerably reduced for typical whole-body MR gradient pulse durations. Here, pig spinal cord tissue and a reference fluid phantom were investigated on a 3 T clinical MR system (40 mT m(-1) ). By averaging over different absolute wave vector orientations, signal variations caused by experimental imperfections like background gradient fields and eddy currents were minimized and a rotationally invariant anisotropy measure could be assessed. A significant microscopic anisotropy was observed in gray and white matter tissue even in the plane perpendicular to the cord which is consistent with previous vertical-bore experiments. Thus, it is demonstrated that double-wave-vector experiments can investigate the microscopic anisotropy on whole-body MR systems.",
keywords = "Animals, Phantoms, Imaging, Swine, Anisotropy, Diffusion, Magnetic Resonance Spectroscopy/*methods, Spinal Cord, *Whole Body Imaging, Animals, Phantoms, Imaging, Swine, Anisotropy, Diffusion, Magnetic Resonance Spectroscopy/*methods, Spinal Cord, *Whole Body Imaging",
author = "Marco Lawrenz and J{\"u}rgen Finsterbusch",
year = "2011",
language = "English",
volume = "66",
pages = "1405--1415",
journal = "MAGN RESON MED",
issn = "0740-3194",
publisher = "John Wiley and Sons Inc.",
number = "5",

}

RIS

TY - JOUR

T1 - Detection of microscopic diffusion anisotropy on a whole-body MR system with double wave vector imaging.

AU - Lawrenz, Marco

AU - Finsterbusch, Jürgen

PY - 2011

Y1 - 2011

N2 - Double-wave-vector diffusion-weighting experiments can detect diffusion anisotropy on a microscopic level which, e.g., could distinguish lower fiber densities from reduced fiber coherence. The underlying signal difference between parallel and orthogonal wave vector orientations has been observed on vertical-bore MR systems (?500 mT m(-1) ); however, numerical simulations reveal that it is expected to be considerably reduced for typical whole-body MR gradient pulse durations. Here, pig spinal cord tissue and a reference fluid phantom were investigated on a 3 T clinical MR system (40 mT m(-1) ). By averaging over different absolute wave vector orientations, signal variations caused by experimental imperfections like background gradient fields and eddy currents were minimized and a rotationally invariant anisotropy measure could be assessed. A significant microscopic anisotropy was observed in gray and white matter tissue even in the plane perpendicular to the cord which is consistent with previous vertical-bore experiments. Thus, it is demonstrated that double-wave-vector experiments can investigate the microscopic anisotropy on whole-body MR systems.

AB - Double-wave-vector diffusion-weighting experiments can detect diffusion anisotropy on a microscopic level which, e.g., could distinguish lower fiber densities from reduced fiber coherence. The underlying signal difference between parallel and orthogonal wave vector orientations has been observed on vertical-bore MR systems (?500 mT m(-1) ); however, numerical simulations reveal that it is expected to be considerably reduced for typical whole-body MR gradient pulse durations. Here, pig spinal cord tissue and a reference fluid phantom were investigated on a 3 T clinical MR system (40 mT m(-1) ). By averaging over different absolute wave vector orientations, signal variations caused by experimental imperfections like background gradient fields and eddy currents were minimized and a rotationally invariant anisotropy measure could be assessed. A significant microscopic anisotropy was observed in gray and white matter tissue even in the plane perpendicular to the cord which is consistent with previous vertical-bore experiments. Thus, it is demonstrated that double-wave-vector experiments can investigate the microscopic anisotropy on whole-body MR systems.

KW - Animals

KW - Phantoms, Imaging

KW - Swine

KW - Anisotropy

KW - Diffusion

KW - Magnetic Resonance Spectroscopy/methods

KW - Spinal Cord

KW - Whole Body Imaging

KW - Animals

KW - Phantoms, Imaging

KW - Swine

KW - Anisotropy

KW - Diffusion

KW - Magnetic Resonance Spectroscopy/methods

KW - Spinal Cord

KW - Whole Body Imaging

M3 - SCORING: Journal article

VL - 66

SP - 1405

EP - 1415

JO - MAGN RESON MED

JF - MAGN RESON MED

SN - 0740-3194

IS - 5

M1 - 5

ER -