Detection of microscopic diffusion anisotropy on a whole-body MR system with double wave vector imaging.
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Detection of microscopic diffusion anisotropy on a whole-body MR system with double wave vector imaging. / Lawrenz, Marco; Finsterbusch, Jürgen.
in: MAGN RESON MED, Jahrgang 66, Nr. 5, 5, 2011, S. 1405-1415.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Detection of microscopic diffusion anisotropy on a whole-body MR system with double wave vector imaging.
AU - Lawrenz, Marco
AU - Finsterbusch, Jürgen
PY - 2011
Y1 - 2011
N2 - Double-wave-vector diffusion-weighting experiments can detect diffusion anisotropy on a microscopic level which, e.g., could distinguish lower fiber densities from reduced fiber coherence. The underlying signal difference between parallel and orthogonal wave vector orientations has been observed on vertical-bore MR systems (?500 mT m(-1) ); however, numerical simulations reveal that it is expected to be considerably reduced for typical whole-body MR gradient pulse durations. Here, pig spinal cord tissue and a reference fluid phantom were investigated on a 3 T clinical MR system (40 mT m(-1) ). By averaging over different absolute wave vector orientations, signal variations caused by experimental imperfections like background gradient fields and eddy currents were minimized and a rotationally invariant anisotropy measure could be assessed. A significant microscopic anisotropy was observed in gray and white matter tissue even in the plane perpendicular to the cord which is consistent with previous vertical-bore experiments. Thus, it is demonstrated that double-wave-vector experiments can investigate the microscopic anisotropy on whole-body MR systems.
AB - Double-wave-vector diffusion-weighting experiments can detect diffusion anisotropy on a microscopic level which, e.g., could distinguish lower fiber densities from reduced fiber coherence. The underlying signal difference between parallel and orthogonal wave vector orientations has been observed on vertical-bore MR systems (?500 mT m(-1) ); however, numerical simulations reveal that it is expected to be considerably reduced for typical whole-body MR gradient pulse durations. Here, pig spinal cord tissue and a reference fluid phantom were investigated on a 3 T clinical MR system (40 mT m(-1) ). By averaging over different absolute wave vector orientations, signal variations caused by experimental imperfections like background gradient fields and eddy currents were minimized and a rotationally invariant anisotropy measure could be assessed. A significant microscopic anisotropy was observed in gray and white matter tissue even in the plane perpendicular to the cord which is consistent with previous vertical-bore experiments. Thus, it is demonstrated that double-wave-vector experiments can investigate the microscopic anisotropy on whole-body MR systems.
KW - Animals
KW - Phantoms, Imaging
KW - Swine
KW - Anisotropy
KW - Diffusion
KW - Magnetic Resonance Spectroscopy/methods
KW - Spinal Cord
KW - Whole Body Imaging
KW - Animals
KW - Phantoms, Imaging
KW - Swine
KW - Anisotropy
KW - Diffusion
KW - Magnetic Resonance Spectroscopy/methods
KW - Spinal Cord
KW - Whole Body Imaging
M3 - SCORING: Journal article
VL - 66
SP - 1405
EP - 1415
JO - MAGN RESON MED
JF - MAGN RESON MED
SN - 0740-3194
IS - 5
M1 - 5
ER -