Detection of Circulating Tumor Cells in Non-Small Cell Lung Cancer

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Detection of Circulating Tumor Cells in Non-Small Cell Lung Cancer. / Hanssen, Annkathrin; Loges, Sonja; Pantel, Klaus; Wikman-Kocher, Harriet.

In: FRONT ONCOL, Vol. 5, 22.09.2015, p. Art. 207.

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@article{047ef97b809748fdbdd746616ba7b31b,
title = "Detection of Circulating Tumor Cells in Non-Small Cell Lung Cancer",
abstract = "Lung cancer is the most common cause of cancer-related deaths that frequently metastasizes prior to disease diagnosis. Circulating tumor cells (CTCs) are found in many different types of epithelial tumors and are of great clinical interest in terms of prognosis and therapy intervention. Here, we present and discuss epithelial cell adhesion molecule-dependent and -independent capture of CTCs in non-small cell lung cancer (NSCLC) and the clinical relevance of CTC detection and characterization. Taking blood samples and analyzing CTCs as {"}liquid biopsy{"} might be a far less invasive diagnostic strategy than biopsies of lung tumors or metastases. Moreover, sequential blood sampling allows to study the dynamic changes of tumor cells during therapy, in particular the development of resistant tumor cell clones.",
author = "Annkathrin Hanssen and Sonja Loges and Klaus Pantel and Harriet Wikman-Kocher",
year = "2015",
month = sep,
day = "22",
doi = "10.3389/fonc.2015.00207",
language = "English",
volume = "5",
pages = "Art. 207",
journal = "FRONT ONCOL",
issn = "2234-943X",
publisher = "Frontiers Media S. A.",

}

RIS

TY - JOUR

T1 - Detection of Circulating Tumor Cells in Non-Small Cell Lung Cancer

AU - Hanssen, Annkathrin

AU - Loges, Sonja

AU - Pantel, Klaus

AU - Wikman-Kocher, Harriet

PY - 2015/9/22

Y1 - 2015/9/22

N2 - Lung cancer is the most common cause of cancer-related deaths that frequently metastasizes prior to disease diagnosis. Circulating tumor cells (CTCs) are found in many different types of epithelial tumors and are of great clinical interest in terms of prognosis and therapy intervention. Here, we present and discuss epithelial cell adhesion molecule-dependent and -independent capture of CTCs in non-small cell lung cancer (NSCLC) and the clinical relevance of CTC detection and characterization. Taking blood samples and analyzing CTCs as "liquid biopsy" might be a far less invasive diagnostic strategy than biopsies of lung tumors or metastases. Moreover, sequential blood sampling allows to study the dynamic changes of tumor cells during therapy, in particular the development of resistant tumor cell clones.

AB - Lung cancer is the most common cause of cancer-related deaths that frequently metastasizes prior to disease diagnosis. Circulating tumor cells (CTCs) are found in many different types of epithelial tumors and are of great clinical interest in terms of prognosis and therapy intervention. Here, we present and discuss epithelial cell adhesion molecule-dependent and -independent capture of CTCs in non-small cell lung cancer (NSCLC) and the clinical relevance of CTC detection and characterization. Taking blood samples and analyzing CTCs as "liquid biopsy" might be a far less invasive diagnostic strategy than biopsies of lung tumors or metastases. Moreover, sequential blood sampling allows to study the dynamic changes of tumor cells during therapy, in particular the development of resistant tumor cell clones.

U2 - 10.3389/fonc.2015.00207

DO - 10.3389/fonc.2015.00207

M3 - SCORING: Journal article

C2 - 26442219

VL - 5

SP - Art. 207

JO - FRONT ONCOL

JF - FRONT ONCOL

SN - 2234-943X

ER -