Detection of Circulating Tumor Cells in Non-Small Cell Lung Cancer
Standard
Detection of Circulating Tumor Cells in Non-Small Cell Lung Cancer. / Hanssen, Annkathrin; Loges, Sonja; Pantel, Klaus; Wikman-Kocher, Harriet.
in: FRONT ONCOL, Jahrgang 5, 22.09.2015, S. Art. 207.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Detection of Circulating Tumor Cells in Non-Small Cell Lung Cancer
AU - Hanssen, Annkathrin
AU - Loges, Sonja
AU - Pantel, Klaus
AU - Wikman-Kocher, Harriet
PY - 2015/9/22
Y1 - 2015/9/22
N2 - Lung cancer is the most common cause of cancer-related deaths that frequently metastasizes prior to disease diagnosis. Circulating tumor cells (CTCs) are found in many different types of epithelial tumors and are of great clinical interest in terms of prognosis and therapy intervention. Here, we present and discuss epithelial cell adhesion molecule-dependent and -independent capture of CTCs in non-small cell lung cancer (NSCLC) and the clinical relevance of CTC detection and characterization. Taking blood samples and analyzing CTCs as "liquid biopsy" might be a far less invasive diagnostic strategy than biopsies of lung tumors or metastases. Moreover, sequential blood sampling allows to study the dynamic changes of tumor cells during therapy, in particular the development of resistant tumor cell clones.
AB - Lung cancer is the most common cause of cancer-related deaths that frequently metastasizes prior to disease diagnosis. Circulating tumor cells (CTCs) are found in many different types of epithelial tumors and are of great clinical interest in terms of prognosis and therapy intervention. Here, we present and discuss epithelial cell adhesion molecule-dependent and -independent capture of CTCs in non-small cell lung cancer (NSCLC) and the clinical relevance of CTC detection and characterization. Taking blood samples and analyzing CTCs as "liquid biopsy" might be a far less invasive diagnostic strategy than biopsies of lung tumors or metastases. Moreover, sequential blood sampling allows to study the dynamic changes of tumor cells during therapy, in particular the development of resistant tumor cell clones.
U2 - 10.3389/fonc.2015.00207
DO - 10.3389/fonc.2015.00207
M3 - SCORING: Journal article
C2 - 26442219
VL - 5
SP - Art. 207
JO - FRONT ONCOL
JF - FRONT ONCOL
SN - 2234-943X
ER -