Designer Neural Networks with Embedded Semiconductor Microtube Arrays.
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Designer Neural Networks with Embedded Semiconductor Microtube Arrays. / Koitmäe, Aune; Müller, Manuel; Bausch, Cornelius S.; Harberts, Jann; Hansen, Wolfgang; Loers, Gabriele; Blick, Robert H.
In: LANGMUIR, Vol. 34, No. 4, 30.01.2018, p. 1528-1534.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Designer Neural Networks with Embedded Semiconductor Microtube Arrays.
AU - Koitmäe, Aune
AU - Müller, Manuel
AU - Bausch, Cornelius S.
AU - Harberts, Jann
AU - Hansen, Wolfgang
AU - Loers, Gabriele
AU - Blick, Robert H.
PY - 2018/1/30
Y1 - 2018/1/30
N2 - Here we present a designer's approach to building cellular neuronal networks based on a biocompatible negative photoresist with embedded coaxial feedthroughs made of semiconductor microtubes. The diameter of the microtubes is tailored and adjusted to the diameter of cerebellum axons having a diameter of 2-3 μm. The microtubes as well as the SU-8 layer serve as a topographical cue to the axons. Apart from the topographical guidance, we also employ chemical guidance cues enhancing neuron growth at designed spots. Therefore, the amino acid poly-l-lysine is printed in droplets of pl volume in the front of the tube entrances. Our artificial neuronal network has an extremely high yield of 85% of the somas settled at the desired locations. We complete this by basic patch-clamp measurements on single cells within the neuronal network.
AB - Here we present a designer's approach to building cellular neuronal networks based on a biocompatible negative photoresist with embedded coaxial feedthroughs made of semiconductor microtubes. The diameter of the microtubes is tailored and adjusted to the diameter of cerebellum axons having a diameter of 2-3 μm. The microtubes as well as the SU-8 layer serve as a topographical cue to the axons. Apart from the topographical guidance, we also employ chemical guidance cues enhancing neuron growth at designed spots. Therefore, the amino acid poly-l-lysine is printed in droplets of pl volume in the front of the tube entrances. Our artificial neuronal network has an extremely high yield of 85% of the somas settled at the desired locations. We complete this by basic patch-clamp measurements on single cells within the neuronal network.
M3 - SCORING: Journal article
VL - 34
SP - 1528
EP - 1534
JO - LANGMUIR
JF - LANGMUIR
SN - 0743-7463
IS - 4
ER -