Designer Neural Networks with Embedded Semiconductor Microtube Arrays.
Standard
Designer Neural Networks with Embedded Semiconductor Microtube Arrays. / Koitmäe, Aune; Müller, Manuel; Bausch, Cornelius S.; Harberts, Jann; Hansen, Wolfgang; Loers, Gabriele; Blick, Robert H.
in: LANGMUIR, Jahrgang 34, Nr. 4, 30.01.2018, S. 1528-1534.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Designer Neural Networks with Embedded Semiconductor Microtube Arrays.
AU - Koitmäe, Aune
AU - Müller, Manuel
AU - Bausch, Cornelius S.
AU - Harberts, Jann
AU - Hansen, Wolfgang
AU - Loers, Gabriele
AU - Blick, Robert H.
PY - 2018/1/30
Y1 - 2018/1/30
N2 - Here we present a designer's approach to building cellular neuronal networks based on a biocompatible negative photoresist with embedded coaxial feedthroughs made of semiconductor microtubes. The diameter of the microtubes is tailored and adjusted to the diameter of cerebellum axons having a diameter of 2-3 μm. The microtubes as well as the SU-8 layer serve as a topographical cue to the axons. Apart from the topographical guidance, we also employ chemical guidance cues enhancing neuron growth at designed spots. Therefore, the amino acid poly-l-lysine is printed in droplets of pl volume in the front of the tube entrances. Our artificial neuronal network has an extremely high yield of 85% of the somas settled at the desired locations. We complete this by basic patch-clamp measurements on single cells within the neuronal network.
AB - Here we present a designer's approach to building cellular neuronal networks based on a biocompatible negative photoresist with embedded coaxial feedthroughs made of semiconductor microtubes. The diameter of the microtubes is tailored and adjusted to the diameter of cerebellum axons having a diameter of 2-3 μm. The microtubes as well as the SU-8 layer serve as a topographical cue to the axons. Apart from the topographical guidance, we also employ chemical guidance cues enhancing neuron growth at designed spots. Therefore, the amino acid poly-l-lysine is printed in droplets of pl volume in the front of the tube entrances. Our artificial neuronal network has an extremely high yield of 85% of the somas settled at the desired locations. We complete this by basic patch-clamp measurements on single cells within the neuronal network.
M3 - SCORING: Journal article
VL - 34
SP - 1528
EP - 1534
JO - LANGMUIR
JF - LANGMUIR
SN - 0743-7463
IS - 4
ER -
