Depression in Alzheimer's disease might be associated with apolipoprotein E epsilon 4 allele frequency in women but not in men.
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Depression in Alzheimer's disease might be associated with apolipoprotein E epsilon 4 allele frequency in women but not in men. / Müller-Thomsen, Thomas; Arlt, Sönke; Ganzer, Stefanie; Mann, Ulrike; Mass, Reinhard; Naber, Dieter; Beisiegel, Ulrike.
In: DEMENT GERIATR COGN, Vol. 14, No. 2, 2, 2002, p. 59-63.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Depression in Alzheimer's disease might be associated with apolipoprotein E epsilon 4 allele frequency in women but not in men.
AU - Müller-Thomsen, Thomas
AU - Arlt, Sönke
AU - Ganzer, Stefanie
AU - Mann, Ulrike
AU - Mass, Reinhard
AU - Naber, Dieter
AU - Beisiegel, Ulrike
PY - 2002
Y1 - 2002
N2 - The association between depression and apolipoprotein E (apoE) was investigated in 137 out-patients with Alzheimer's disease. An ICD-10 diagnosis of depression was found in 21.1% of all patients. There was a good correlation between clinicians' diagnoses and blinded rating by the Montgomery-Asberg Depression Rating Scale (r = 0.70). In male patients, apoE 3/3 was detected in 34.1%, 3/4 in 38.6%, 4/4 in 13.6%, 2/4 in 6.8% and 2/3 in 6.8% of cases. In female patients, apoE 3/3 was detected in 35.5%, 3/4 in 45.2%, 4/4 in 12.8%, 2/4 in 3.2% and 2/3 in 3.2% of cases. When analyzing the variance of gene dosage effect, the frequency of the apoE epsilon 4 allele was significantly increased in depressed women but not in men. This effect remained stable in stepwise regression analysis when depression as the dependent variable was tested against the independent variables age, age of onset, duration of disease, cognitive status and years of school education.
AB - The association between depression and apolipoprotein E (apoE) was investigated in 137 out-patients with Alzheimer's disease. An ICD-10 diagnosis of depression was found in 21.1% of all patients. There was a good correlation between clinicians' diagnoses and blinded rating by the Montgomery-Asberg Depression Rating Scale (r = 0.70). In male patients, apoE 3/3 was detected in 34.1%, 3/4 in 38.6%, 4/4 in 13.6%, 2/4 in 6.8% and 2/3 in 6.8% of cases. In female patients, apoE 3/3 was detected in 35.5%, 3/4 in 45.2%, 4/4 in 12.8%, 2/4 in 3.2% and 2/3 in 3.2% of cases. When analyzing the variance of gene dosage effect, the frequency of the apoE epsilon 4 allele was significantly increased in depressed women but not in men. This effect remained stable in stepwise regression analysis when depression as the dependent variable was tested against the independent variables age, age of onset, duration of disease, cognitive status and years of school education.
M3 - SCORING: Zeitschriftenaufsatz
VL - 14
SP - 59
EP - 63
JO - DEMENT GERIATR COGN
JF - DEMENT GERIATR COGN
SN - 1420-8008
IS - 2
M1 - 2
ER -