PortalPublikationenDepression in Alzheimer's disease might be associated with a...

Depression in Alzheimer's disease might be associated with apolipoprotein E epsilon 4 allele frequency in women but not in men.

Standard

Depression in Alzheimer's disease might be associated with apolipoprotein E epsilon 4 allele frequency in women but not in men. / Müller-Thomsen, Thomas; Arlt, Sönke; Ganzer, Stefanie; Mann, Ulrike; Mass, Reinhard; Naber, Dieter; Beisiegel, Ulrike.

in: DEMENT GERIATR COGN, Jahrgang 14, Nr. 2, 2, 2002, S. 59-63.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Müller-Thomsen, T, Arlt, S, Ganzer, S, Mann, U, Mass, R, Naber, D & Beisiegel, U 2002, 'Depression in Alzheimer's disease might be associated with apolipoprotein E epsilon 4 allele frequency in women but not in men.', DEMENT GERIATR COGN, Jg. 14, Nr. 2, 2, S. 59-63. <http://www.ncbi.nlm.nih.gov/pubmed/12145452?dopt=Citation>

APA

Müller-Thomsen, T., Arlt, S., Ganzer, S., Mann, U., Mass, R., Naber, D., & Beisiegel, U. (2002). Depression in Alzheimer's disease might be associated with apolipoprotein E epsilon 4 allele frequency in women but not in men. DEMENT GERIATR COGN, 14(2), 59-63. [2]. http://www.ncbi.nlm.nih.gov/pubmed/12145452?dopt=Citation

Vancouver

Müller-Thomsen T, Arlt S, Ganzer S, Mann U, Mass R, Naber D et al. Depression in Alzheimer's disease might be associated with apolipoprotein E epsilon 4 allele frequency in women but not in men. DEMENT GERIATR COGN. 2002;14(2):59-63. 2.

Bibtex

@article{5c380d1ca01743659b62a813541dc123,
title = "Depression in Alzheimer's disease might be associated with apolipoprotein E epsilon 4 allele frequency in women but not in men.",
abstract = "The association between depression and apolipoprotein E (apoE) was investigated in 137 out-patients with Alzheimer's disease. An ICD-10 diagnosis of depression was found in 21.1% of all patients. There was a good correlation between clinicians' diagnoses and blinded rating by the Montgomery-Asberg Depression Rating Scale (r = 0.70). In male patients, apoE 3/3 was detected in 34.1%, 3/4 in 38.6%, 4/4 in 13.6%, 2/4 in 6.8% and 2/3 in 6.8% of cases. In female patients, apoE 3/3 was detected in 35.5%, 3/4 in 45.2%, 4/4 in 12.8%, 2/4 in 3.2% and 2/3 in 3.2% of cases. When analyzing the variance of gene dosage effect, the frequency of the apoE epsilon 4 allele was significantly increased in depressed women but not in men. This effect remained stable in stepwise regression analysis when depression as the dependent variable was tested against the independent variables age, age of onset, duration of disease, cognitive status and years of school education.",
author = "Thomas M{\"u}ller-Thomsen and S{\"o}nke Arlt and Stefanie Ganzer and Ulrike Mann and Reinhard Mass and Dieter Naber and Ulrike Beisiegel",
year = "2002",
language = "Deutsch",
volume = "14",
pages = "59--63",
journal = "DEMENT GERIATR COGN",
issn = "1420-8008",
publisher = "S. Karger AG",
number = "2",

}

RIS

TY - JOUR

T1 - Depression in Alzheimer's disease might be associated with apolipoprotein E epsilon 4 allele frequency in women but not in men.

AU - Müller-Thomsen, Thomas

AU - Arlt, Sönke

AU - Ganzer, Stefanie

AU - Mann, Ulrike

AU - Mass, Reinhard

AU - Naber, Dieter

AU - Beisiegel, Ulrike

PY - 2002

Y1 - 2002

N2 - The association between depression and apolipoprotein E (apoE) was investigated in 137 out-patients with Alzheimer's disease. An ICD-10 diagnosis of depression was found in 21.1% of all patients. There was a good correlation between clinicians' diagnoses and blinded rating by the Montgomery-Asberg Depression Rating Scale (r = 0.70). In male patients, apoE 3/3 was detected in 34.1%, 3/4 in 38.6%, 4/4 in 13.6%, 2/4 in 6.8% and 2/3 in 6.8% of cases. In female patients, apoE 3/3 was detected in 35.5%, 3/4 in 45.2%, 4/4 in 12.8%, 2/4 in 3.2% and 2/3 in 3.2% of cases. When analyzing the variance of gene dosage effect, the frequency of the apoE epsilon 4 allele was significantly increased in depressed women but not in men. This effect remained stable in stepwise regression analysis when depression as the dependent variable was tested against the independent variables age, age of onset, duration of disease, cognitive status and years of school education.

AB - The association between depression and apolipoprotein E (apoE) was investigated in 137 out-patients with Alzheimer's disease. An ICD-10 diagnosis of depression was found in 21.1% of all patients. There was a good correlation between clinicians' diagnoses and blinded rating by the Montgomery-Asberg Depression Rating Scale (r = 0.70). In male patients, apoE 3/3 was detected in 34.1%, 3/4 in 38.6%, 4/4 in 13.6%, 2/4 in 6.8% and 2/3 in 6.8% of cases. In female patients, apoE 3/3 was detected in 35.5%, 3/4 in 45.2%, 4/4 in 12.8%, 2/4 in 3.2% and 2/3 in 3.2% of cases. When analyzing the variance of gene dosage effect, the frequency of the apoE epsilon 4 allele was significantly increased in depressed women but not in men. This effect remained stable in stepwise regression analysis when depression as the dependent variable was tested against the independent variables age, age of onset, duration of disease, cognitive status and years of school education.

M3 - SCORING: Zeitschriftenaufsatz

VL - 14

SP - 59

EP - 63

JO - DEMENT GERIATR COGN

JF - DEMENT GERIATR COGN

SN - 1420-8008

IS - 2

M1 - 2

ER -