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Depletion of CD4+ T cells during immunization with nonviable Listeria monocytogenes causes enhanced CD8+ T cell-mediated protection against listeriosis

Standard

Depletion of CD4+ T cells during immunization with nonviable Listeria monocytogenes causes enhanced CD8+ T cell-mediated protection against listeriosis. / Kursar, Mischo; Köhler, Anne; Kaufmann, Stefan H E; Mittrücker, Hans-Willi.

In: J IMMUNOL, Vol. 172, No. 5, 01.03.2004, p. 3167-72.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kursar, M, Köhler, A, Kaufmann, SHE & Mittrücker, H-W 2004, 'Depletion of CD4+ T cells during immunization with nonviable Listeria monocytogenes causes enhanced CD8+ T cell-mediated protection against listeriosis', J IMMUNOL, vol. 172, no. 5, pp. 3167-72.

APA

Kursar, M., Köhler, A., Kaufmann, S. H. E., & Mittrücker, H-W. (2004). Depletion of CD4+ T cells during immunization with nonviable Listeria monocytogenes causes enhanced CD8+ T cell-mediated protection against listeriosis. J IMMUNOL, 172(5), 3167-72.

Vancouver

Kursar M, Köhler A, Kaufmann SHE, Mittrücker H-W. Depletion of CD4+ T cells during immunization with nonviable Listeria monocytogenes causes enhanced CD8+ T cell-mediated protection against listeriosis. J IMMUNOL. 2004 Mar 1;172(5):3167-72.

Bibtex

@article{fb6df847f799495dbc6b8a19fb09c86d,
title = "Depletion of CD4+ T cells during immunization with nonviable Listeria monocytogenes causes enhanced CD8+ T cell-mediated protection against listeriosis",
abstract = "Immunization of mice with nonviable Listeria monocytogenes generates an insufficient CD8(+) T cell response and consequently only limited protection against subsequent L. monocytogenes infection. We have recently demonstrated that depletion of regulatory CD4(+) T cells during immunization significantly enhances CD8(+) T cell responses. In the present study, we determined the impact of CD4(+) T cell depletion on the CD8(+) T cell response against heat-killed Listeria. Treatment of mice with anti-CD4 mAb during boost immunization with heat-killed Listeria significantly increased numbers of Listeria-specific CD8(+) T cells and improved protection against subsequent infection with L. monocytogenes. During challenge infection, numbers of Listeria-specific CD8(+) T cells were enhanced, and these cells expressed effector functions in terms of IFN-gamma production. In summary, we demonstrate that combining nonviable L. monocytogenes vaccination and CD4(+) T cell depletion improves generation of long-lasting and functional Listeria-specific CD8(+) memory T cells.",
keywords = "Animals, Antibodies, Monoclonal, Antigens, CD4, Bacterial Vaccines, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Cytotoxicity, Immunologic, Immunization, Secondary, Injections, Intraperitoneal, Listeria monocytogenes, Listeriosis, Lymphocyte Activation, Lymphocyte Count, Lymphocyte Depletion, Mice, Mice, Inbred BALB C",
author = "Mischo Kursar and Anne K{\"o}hler and Kaufmann, {Stefan H E} and Hans-Willi Mittr{\"u}cker",
year = "2004",
month = mar,
day = "1",
language = "English",
volume = "172",
pages = "3167--72",
journal = "J IMMUNOL",
issn = "0022-1767",
publisher = "American Association of Immunologists",
number = "5",

}

RIS

TY - JOUR

T1 - Depletion of CD4+ T cells during immunization with nonviable Listeria monocytogenes causes enhanced CD8+ T cell-mediated protection against listeriosis

AU - Kursar, Mischo

AU - Köhler, Anne

AU - Kaufmann, Stefan H E

AU - Mittrücker, Hans-Willi

PY - 2004/3/1

Y1 - 2004/3/1

N2 - Immunization of mice with nonviable Listeria monocytogenes generates an insufficient CD8(+) T cell response and consequently only limited protection against subsequent L. monocytogenes infection. We have recently demonstrated that depletion of regulatory CD4(+) T cells during immunization significantly enhances CD8(+) T cell responses. In the present study, we determined the impact of CD4(+) T cell depletion on the CD8(+) T cell response against heat-killed Listeria. Treatment of mice with anti-CD4 mAb during boost immunization with heat-killed Listeria significantly increased numbers of Listeria-specific CD8(+) T cells and improved protection against subsequent infection with L. monocytogenes. During challenge infection, numbers of Listeria-specific CD8(+) T cells were enhanced, and these cells expressed effector functions in terms of IFN-gamma production. In summary, we demonstrate that combining nonviable L. monocytogenes vaccination and CD4(+) T cell depletion improves generation of long-lasting and functional Listeria-specific CD8(+) memory T cells.

AB - Immunization of mice with nonviable Listeria monocytogenes generates an insufficient CD8(+) T cell response and consequently only limited protection against subsequent L. monocytogenes infection. We have recently demonstrated that depletion of regulatory CD4(+) T cells during immunization significantly enhances CD8(+) T cell responses. In the present study, we determined the impact of CD4(+) T cell depletion on the CD8(+) T cell response against heat-killed Listeria. Treatment of mice with anti-CD4 mAb during boost immunization with heat-killed Listeria significantly increased numbers of Listeria-specific CD8(+) T cells and improved protection against subsequent infection with L. monocytogenes. During challenge infection, numbers of Listeria-specific CD8(+) T cells were enhanced, and these cells expressed effector functions in terms of IFN-gamma production. In summary, we demonstrate that combining nonviable L. monocytogenes vaccination and CD4(+) T cell depletion improves generation of long-lasting and functional Listeria-specific CD8(+) memory T cells.

KW - Animals

KW - Antibodies, Monoclonal

KW - Antigens, CD4

KW - Bacterial Vaccines

KW - CD4-Positive T-Lymphocytes

KW - CD8-Positive T-Lymphocytes

KW - Cytotoxicity, Immunologic

KW - Immunization, Secondary

KW - Injections, Intraperitoneal

KW - Listeria monocytogenes

KW - Listeriosis

KW - Lymphocyte Activation

KW - Lymphocyte Count

KW - Lymphocyte Depletion

KW - Mice

KW - Mice, Inbred BALB C

M3 - SCORING: Journal article

C2 - 14978123

VL - 172

SP - 3167

EP - 3172

JO - J IMMUNOL

JF - J IMMUNOL

SN - 0022-1767

IS - 5

ER -