Dendritic Kv4.2 potassium channels selectively mediate spatial pattern separation in the dentate gyrus
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Dendritic Kv4.2 potassium channels selectively mediate spatial pattern separation in the dentate gyrus. / Oulé, Marie; Atucha, Erika; Wells, Tenyse M; Macharadze, Tamar; Sauvage, Magdalena M; Kreutz, Michael R; Lopez-Rojas, Jeffrey.
In: ISCIENCE, Vol. 24, No. 8, 102876, 20.08.2021.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Dendritic Kv4.2 potassium channels selectively mediate spatial pattern separation in the dentate gyrus
AU - Oulé, Marie
AU - Atucha, Erika
AU - Wells, Tenyse M
AU - Macharadze, Tamar
AU - Sauvage, Magdalena M
AU - Kreutz, Michael R
AU - Lopez-Rojas, Jeffrey
N1 - © 2021 The Author(s).
PY - 2021/8/20
Y1 - 2021/8/20
N2 - The capacity to distinguish comparable experiences is fundamental for the recall of similar memories and has been proposed to require pattern separation in the dentate gyrus (DG). However, the cellular mechanisms by which mature granule cells (GCs) of the DG accomplish this function are poorly characterized. Here, we show that Kv4.2 channels selectively modulate the excitability of medial dendrites of dentate GCs. These dendrites are targeted by the medial entorhinal cortex, the main source of spatial inputs to the DG. Accordingly, we found that the spatial pattern separation capability of animals lacking the Kv4.2 channel is significantly impaired. This points to the role of intrinsic excitability in supporting the mnemonic function of the dentate and to the Kv4.2 channel as a candidate substrate promoting spatial pattern separation.
AB - The capacity to distinguish comparable experiences is fundamental for the recall of similar memories and has been proposed to require pattern separation in the dentate gyrus (DG). However, the cellular mechanisms by which mature granule cells (GCs) of the DG accomplish this function are poorly characterized. Here, we show that Kv4.2 channels selectively modulate the excitability of medial dendrites of dentate GCs. These dendrites are targeted by the medial entorhinal cortex, the main source of spatial inputs to the DG. Accordingly, we found that the spatial pattern separation capability of animals lacking the Kv4.2 channel is significantly impaired. This points to the role of intrinsic excitability in supporting the mnemonic function of the dentate and to the Kv4.2 channel as a candidate substrate promoting spatial pattern separation.
U2 - 10.1016/j.isci.2021.102876
DO - 10.1016/j.isci.2021.102876
M3 - SCORING: Journal article
C2 - 34386734
VL - 24
JO - ISCIENCE
JF - ISCIENCE
SN - 2589-0042
IS - 8
M1 - 102876
ER -