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Dendritic Kv4.2 potassium channels selectively mediate spatial pattern separation in the dentate gyrus

Standard

Dendritic Kv4.2 potassium channels selectively mediate spatial pattern separation in the dentate gyrus. / Oulé, Marie; Atucha, Erika; Wells, Tenyse M; Macharadze, Tamar; Sauvage, Magdalena M; Kreutz, Michael R; Lopez-Rojas, Jeffrey.

in: ISCIENCE, Jahrgang 24, Nr. 8, 102876, 20.08.2021.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Oulé, M, Atucha, E, Wells, TM, Macharadze, T, Sauvage, MM, Kreutz, MR & Lopez-Rojas, J 2021, 'Dendritic Kv4.2 potassium channels selectively mediate spatial pattern separation in the dentate gyrus', ISCIENCE, Jg. 24, Nr. 8, 102876. https://doi.org/10.1016/j.isci.2021.102876

APA

Oulé, M., Atucha, E., Wells, T. M., Macharadze, T., Sauvage, M. M., Kreutz, M. R., & Lopez-Rojas, J. (2021). Dendritic Kv4.2 potassium channels selectively mediate spatial pattern separation in the dentate gyrus. ISCIENCE, 24(8), [102876]. https://doi.org/10.1016/j.isci.2021.102876

Vancouver

Oulé M, Atucha E, Wells TM, Macharadze T, Sauvage MM, Kreutz MR et al. Dendritic Kv4.2 potassium channels selectively mediate spatial pattern separation in the dentate gyrus. ISCIENCE. 2021 Aug 20;24(8). 102876. https://doi.org/10.1016/j.isci.2021.102876

Bibtex

@article{98363639b69c4b36b60b338fca54ca05,
title = "Dendritic Kv4.2 potassium channels selectively mediate spatial pattern separation in the dentate gyrus",
abstract = "The capacity to distinguish comparable experiences is fundamental for the recall of similar memories and has been proposed to require pattern separation in the dentate gyrus (DG). However, the cellular mechanisms by which mature granule cells (GCs) of the DG accomplish this function are poorly characterized. Here, we show that Kv4.2 channels selectively modulate the excitability of medial dendrites of dentate GCs. These dendrites are targeted by the medial entorhinal cortex, the main source of spatial inputs to the DG. Accordingly, we found that the spatial pattern separation capability of animals lacking the Kv4.2 channel is significantly impaired. This points to the role of intrinsic excitability in supporting the mnemonic function of the dentate and to the Kv4.2 channel as a candidate substrate promoting spatial pattern separation.",
author = "Marie Oul{\'e} and Erika Atucha and Wells, {Tenyse M} and Tamar Macharadze and Sauvage, {Magdalena M} and Kreutz, {Michael R} and Jeffrey Lopez-Rojas",
note = "{\textcopyright} 2021 The Author(s).",
year = "2021",
month = aug,
day = "20",
doi = "10.1016/j.isci.2021.102876",
language = "English",
volume = "24",
journal = "ISCIENCE",
issn = "2589-0042",
publisher = "Elsevier Inc.",
number = "8",

}

RIS

TY - JOUR

T1 - Dendritic Kv4.2 potassium channels selectively mediate spatial pattern separation in the dentate gyrus

AU - Oulé, Marie

AU - Atucha, Erika

AU - Wells, Tenyse M

AU - Macharadze, Tamar

AU - Sauvage, Magdalena M

AU - Kreutz, Michael R

AU - Lopez-Rojas, Jeffrey

N1 - © 2021 The Author(s).

PY - 2021/8/20

Y1 - 2021/8/20

N2 - The capacity to distinguish comparable experiences is fundamental for the recall of similar memories and has been proposed to require pattern separation in the dentate gyrus (DG). However, the cellular mechanisms by which mature granule cells (GCs) of the DG accomplish this function are poorly characterized. Here, we show that Kv4.2 channels selectively modulate the excitability of medial dendrites of dentate GCs. These dendrites are targeted by the medial entorhinal cortex, the main source of spatial inputs to the DG. Accordingly, we found that the spatial pattern separation capability of animals lacking the Kv4.2 channel is significantly impaired. This points to the role of intrinsic excitability in supporting the mnemonic function of the dentate and to the Kv4.2 channel as a candidate substrate promoting spatial pattern separation.

AB - The capacity to distinguish comparable experiences is fundamental for the recall of similar memories and has been proposed to require pattern separation in the dentate gyrus (DG). However, the cellular mechanisms by which mature granule cells (GCs) of the DG accomplish this function are poorly characterized. Here, we show that Kv4.2 channels selectively modulate the excitability of medial dendrites of dentate GCs. These dendrites are targeted by the medial entorhinal cortex, the main source of spatial inputs to the DG. Accordingly, we found that the spatial pattern separation capability of animals lacking the Kv4.2 channel is significantly impaired. This points to the role of intrinsic excitability in supporting the mnemonic function of the dentate and to the Kv4.2 channel as a candidate substrate promoting spatial pattern separation.

U2 - 10.1016/j.isci.2021.102876

DO - 10.1016/j.isci.2021.102876

M3 - SCORING: Journal article

C2 - 34386734

VL - 24

JO - ISCIENCE

JF - ISCIENCE

SN - 2589-0042

IS - 8

M1 - 102876

ER -