Decreased demand for olfactory periglomerular cells impacts on neural precursor cell viability in the rostral migratory stream

Standard

Decreased demand for olfactory periglomerular cells impacts on neural precursor cell viability in the rostral migratory stream. / Langenfurth, Anika; Gu, Song; Bautze, Verena; Zhang, Caiyi; Neumann, Julia E; Schüller, Ulrich; Stock, Kristin; Wolf, Susanne A; Maier, Anna-Maria; Mastrella, Giorgia; Pak, Andrew; Cheng, Hongwei; Kälin, Roland E; Holmbeck, Kenn; Strotmann, Jörg; Kettenmann, Helmut; Glass, Rainer.

In: SCI REP-UK, Vol. 6, 30.08.2016, p. 32203.

Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

Harvard

Langenfurth, A, Gu, S, Bautze, V, Zhang, C, Neumann, JE, Schüller, U, Stock, K, Wolf, SA, Maier, A-M, Mastrella, G, Pak, A, Cheng, H, Kälin, RE, Holmbeck, K, Strotmann, J, Kettenmann, H & Glass, R 2016, 'Decreased demand for olfactory periglomerular cells impacts on neural precursor cell viability in the rostral migratory stream', SCI REP-UK, vol. 6, pp. 32203. https://doi.org/10.1038/srep32203

APA

Langenfurth, A., Gu, S., Bautze, V., Zhang, C., Neumann, J. E., Schüller, U., Stock, K., Wolf, S. A., Maier, A-M., Mastrella, G., Pak, A., Cheng, H., Kälin, R. E., Holmbeck, K., Strotmann, J., Kettenmann, H., & Glass, R. (2016). Decreased demand for olfactory periglomerular cells impacts on neural precursor cell viability in the rostral migratory stream. SCI REP-UK, 6, 32203. https://doi.org/10.1038/srep32203

Vancouver

Bibtex

@article{3b172698c3fe4ff196c245c90500cde5,
title = "Decreased demand for olfactory periglomerular cells impacts on neural precursor cell viability in the rostral migratory stream",
abstract = "The subventricular zone (SVZ) provides a constant supply of new neurons to the olfactory bulb (OB). Different studies have investigated the role of olfactory sensory input to neural precursor cell (NPC) turnover in the SVZ but it was not addressed if a reduced demand specifically for periglomerular neurons impacts on NPC-traits in the rostral migratory stream (RMS). We here report that membrane type-1 matrix metalloproteinase (MT1-MMP) deficient mice have reduced complexity of the nasal turbinates, decreased sensory innervation of the OB, reduced numbers of olfactory glomeruli and reduced OB-size without alterations in SVZ neurogenesis. Large parts of the RMS were fully preserved in MT1-MMP-deficient mice, but we detected an increase in cell death-levels and a decrease in SVZ-derived neuroblasts in the distal RMS, as compared to controls. BrdU-tracking experiments showed that homing of NPCs specifically to the glomerular layer was reduced in MT1-MMP-deficient mice in contrast to controls while numbers of tracked cells remained equal in other OB-layers throughout all experimental groups. Altogether, our data show the demand for olfactory interneurons in the glomerular layer modulates cell turnover in the RMS, but has no impact on subventricular neurogenesis.",
keywords = "Journal Article",
author = "Anika Langenfurth and Song Gu and Verena Bautze and Caiyi Zhang and Neumann, {Julia E} and Ulrich Sch{\"u}ller and Kristin Stock and Wolf, {Susanne A} and Anna-Maria Maier and Giorgia Mastrella and Andrew Pak and Hongwei Cheng and K{\"a}lin, {Roland E} and Kenn Holmbeck and J{\"o}rg Strotmann and Helmut Kettenmann and Rainer Glass",
year = "2016",
month = aug,
day = "30",
doi = "10.1038/srep32203",
language = "English",
volume = "6",
pages = "32203",
journal = "SCI REP-UK",
issn = "2045-2322",
publisher = "NATURE PUBLISHING GROUP",

}

RIS

TY - JOUR

T1 - Decreased demand for olfactory periglomerular cells impacts on neural precursor cell viability in the rostral migratory stream

AU - Langenfurth, Anika

AU - Gu, Song

AU - Bautze, Verena

AU - Zhang, Caiyi

AU - Neumann, Julia E

AU - Schüller, Ulrich

AU - Stock, Kristin

AU - Wolf, Susanne A

AU - Maier, Anna-Maria

AU - Mastrella, Giorgia

AU - Pak, Andrew

AU - Cheng, Hongwei

AU - Kälin, Roland E

AU - Holmbeck, Kenn

AU - Strotmann, Jörg

AU - Kettenmann, Helmut

AU - Glass, Rainer

PY - 2016/8/30

Y1 - 2016/8/30

N2 - The subventricular zone (SVZ) provides a constant supply of new neurons to the olfactory bulb (OB). Different studies have investigated the role of olfactory sensory input to neural precursor cell (NPC) turnover in the SVZ but it was not addressed if a reduced demand specifically for periglomerular neurons impacts on NPC-traits in the rostral migratory stream (RMS). We here report that membrane type-1 matrix metalloproteinase (MT1-MMP) deficient mice have reduced complexity of the nasal turbinates, decreased sensory innervation of the OB, reduced numbers of olfactory glomeruli and reduced OB-size without alterations in SVZ neurogenesis. Large parts of the RMS were fully preserved in MT1-MMP-deficient mice, but we detected an increase in cell death-levels and a decrease in SVZ-derived neuroblasts in the distal RMS, as compared to controls. BrdU-tracking experiments showed that homing of NPCs specifically to the glomerular layer was reduced in MT1-MMP-deficient mice in contrast to controls while numbers of tracked cells remained equal in other OB-layers throughout all experimental groups. Altogether, our data show the demand for olfactory interneurons in the glomerular layer modulates cell turnover in the RMS, but has no impact on subventricular neurogenesis.

AB - The subventricular zone (SVZ) provides a constant supply of new neurons to the olfactory bulb (OB). Different studies have investigated the role of olfactory sensory input to neural precursor cell (NPC) turnover in the SVZ but it was not addressed if a reduced demand specifically for periglomerular neurons impacts on NPC-traits in the rostral migratory stream (RMS). We here report that membrane type-1 matrix metalloproteinase (MT1-MMP) deficient mice have reduced complexity of the nasal turbinates, decreased sensory innervation of the OB, reduced numbers of olfactory glomeruli and reduced OB-size without alterations in SVZ neurogenesis. Large parts of the RMS were fully preserved in MT1-MMP-deficient mice, but we detected an increase in cell death-levels and a decrease in SVZ-derived neuroblasts in the distal RMS, as compared to controls. BrdU-tracking experiments showed that homing of NPCs specifically to the glomerular layer was reduced in MT1-MMP-deficient mice in contrast to controls while numbers of tracked cells remained equal in other OB-layers throughout all experimental groups. Altogether, our data show the demand for olfactory interneurons in the glomerular layer modulates cell turnover in the RMS, but has no impact on subventricular neurogenesis.

KW - Journal Article

U2 - 10.1038/srep32203

DO - 10.1038/srep32203

M3 - SCORING: Journal article

C2 - 27573347

VL - 6

SP - 32203

JO - SCI REP-UK

JF - SCI REP-UK

SN - 2045-2322

ER -