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Decrease of lethal infectious complications in the context of causes of death (COD) after hematopoietic cell transplantation: COD-2 and COD-1 study of the Infectious Diseases Working Party EBMT

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Decrease of lethal infectious complications in the context of causes of death (COD) after hematopoietic cell transplantation: COD-2 and COD-1 study of the Infectious Diseases Working Party EBMT. / Styczynski, Jan; Tridello, Gloria; Koster, Linda; Knelange, Nina; Wendel, Lotus; van Biezen, Anja; van der Werf, Steffie; Mikulska, Malgorzata; Gil, Lidia; Cordonnier, Catherine; Ljungman, Per; Averbuch, Diana; Cesaro, Simone; Baldomero, Helen; Chabannon, Christian; Corbacioglu, Selim; Dolstra, Harry; Glass, Bertram; Greco, Raffaella; Kröger, Nicolaus; de Latour, Régis Peffault; Mohty, Mohamad; Neven, Benedicte; Peric, Zinaida; Snowden, John A; Sureda, Anna; Yakoub-Agha, Ibrahim; de la Camara, Rafael.

In: BONE MARROW TRANSPL, Vol. 58, No. 8, 08.2023, p. 881-892.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Styczynski, J, Tridello, G, Koster, L, Knelange, N, Wendel, L, van Biezen, A, van der Werf, S, Mikulska, M, Gil, L, Cordonnier, C, Ljungman, P, Averbuch, D, Cesaro, S, Baldomero, H, Chabannon, C, Corbacioglu, S, Dolstra, H, Glass, B, Greco, R, Kröger, N, de Latour, RP, Mohty, M, Neven, B, Peric, Z, Snowden, JA, Sureda, A, Yakoub-Agha, I & de la Camara, R 2023, 'Decrease of lethal infectious complications in the context of causes of death (COD) after hematopoietic cell transplantation: COD-2 and COD-1 study of the Infectious Diseases Working Party EBMT', BONE MARROW TRANSPL, vol. 58, no. 8, pp. 881-892. https://doi.org/10.1038/s41409-023-01998-2

APA

Styczynski, J., Tridello, G., Koster, L., Knelange, N., Wendel, L., van Biezen, A., van der Werf, S., Mikulska, M., Gil, L., Cordonnier, C., Ljungman, P., Averbuch, D., Cesaro, S., Baldomero, H., Chabannon, C., Corbacioglu, S., Dolstra, H., Glass, B., Greco, R., ... de la Camara, R. (2023). Decrease of lethal infectious complications in the context of causes of death (COD) after hematopoietic cell transplantation: COD-2 and COD-1 study of the Infectious Diseases Working Party EBMT. BONE MARROW TRANSPL, 58(8), 881-892. https://doi.org/10.1038/s41409-023-01998-2

Vancouver

Styczynski J, Tridello G, Koster L, Knelange N, Wendel L, van Biezen A et al. Decrease of lethal infectious complications in the context of causes of death (COD) after hematopoietic cell transplantation: COD-2 and COD-1 study of the Infectious Diseases Working Party EBMT. BONE MARROW TRANSPL. 2023 Aug;58(8):881-892. https://doi.org/10.1038/s41409-023-01998-2

Bibtex

@article{fbdf4feec57e4ccd94d23f6709f30c1d,
title = "Decrease of lethal infectious complications in the context of causes of death (COD) after hematopoietic cell transplantation: COD-2 and COD-1 study of the Infectious Diseases Working Party EBMT",
abstract = "We previously analyzed trends in incidence and factors associated with lethal complications in ALL/AML/CML patients (causes of deaths; COD-1 study). The objective of this study was the analysis of incidence and specific causes of death after HCT, with focus on infectious deaths in two time periods, 1980-2001 (cohort-1) and 2002-2015 (cohort-2). All patients with HCT for lymphoma, plasma cell disorders, chronic leukemia (except CML), myelodysplastic/myeloproliferative disorders, registered in the EBMT-ProMISe-database were included (n = 232,618) (COD-2 study). Results were compared to those in the ALL/AML/CML COD-1 study. Mortality from bacterial, viral, fungal, and parasitic infections decreased in very early, early and intermediate phases. In the late phase, mortality from bacterial infections increased, while mortality from fungal, viral, or unknown infectious etiology did not change. This pattern was similar for allo- and auto-HCT in COD-1 and COD-2 studies, with a distinct and constant lower incidence of all types of infections at all phases, after auto-HCT. In conclusion, infections were the main cause of death before day +100, followed by relapse. Mortality from infectious deaths significantly decreased, except late phase. Post-transplant mortality has significantly decreased in all phases, from all causes after auto-HCT; it has decreased in all phases after allo-HCT except late phase.",
keywords = "Humans, Cause of Death, Hematopoietic Stem Cell Transplantation/methods, Communicable Diseases/etiology, Lymphoma, Chronic Disease, Leukemia, Myeloid, Acute/etiology, Retrospective Studies",
author = "Jan Styczynski and Gloria Tridello and Linda Koster and Nina Knelange and Lotus Wendel and {van Biezen}, Anja and {van der Werf}, Steffie and Malgorzata Mikulska and Lidia Gil and Catherine Cordonnier and Per Ljungman and Diana Averbuch and Simone Cesaro and Helen Baldomero and Christian Chabannon and Selim Corbacioglu and Harry Dolstra and Bertram Glass and Raffaella Greco and Nicolaus Kr{\"o}ger and {de Latour}, {R{\'e}gis Peffault} and Mohamad Mohty and Benedicte Neven and Zinaida Peric and Snowden, {John A} and Anna Sureda and Ibrahim Yakoub-Agha and {de la Camara}, Rafael",
note = "{\textcopyright} 2023. The Author(s), under exclusive licence to Springer Nature Limited.",
year = "2023",
month = aug,
doi = "10.1038/s41409-023-01998-2",
language = "English",
volume = "58",
pages = "881--892",
journal = "BONE MARROW TRANSPL",
issn = "0268-3369",
publisher = "NATURE PUBLISHING GROUP",
number = "8",

}

RIS

TY - JOUR

T1 - Decrease of lethal infectious complications in the context of causes of death (COD) after hematopoietic cell transplantation: COD-2 and COD-1 study of the Infectious Diseases Working Party EBMT

AU - Styczynski, Jan

AU - Tridello, Gloria

AU - Koster, Linda

AU - Knelange, Nina

AU - Wendel, Lotus

AU - van Biezen, Anja

AU - van der Werf, Steffie

AU - Mikulska, Malgorzata

AU - Gil, Lidia

AU - Cordonnier, Catherine

AU - Ljungman, Per

AU - Averbuch, Diana

AU - Cesaro, Simone

AU - Baldomero, Helen

AU - Chabannon, Christian

AU - Corbacioglu, Selim

AU - Dolstra, Harry

AU - Glass, Bertram

AU - Greco, Raffaella

AU - Kröger, Nicolaus

AU - de Latour, Régis Peffault

AU - Mohty, Mohamad

AU - Neven, Benedicte

AU - Peric, Zinaida

AU - Snowden, John A

AU - Sureda, Anna

AU - Yakoub-Agha, Ibrahim

AU - de la Camara, Rafael

N1 - © 2023. The Author(s), under exclusive licence to Springer Nature Limited.

PY - 2023/8

Y1 - 2023/8

N2 - We previously analyzed trends in incidence and factors associated with lethal complications in ALL/AML/CML patients (causes of deaths; COD-1 study). The objective of this study was the analysis of incidence and specific causes of death after HCT, with focus on infectious deaths in two time periods, 1980-2001 (cohort-1) and 2002-2015 (cohort-2). All patients with HCT for lymphoma, plasma cell disorders, chronic leukemia (except CML), myelodysplastic/myeloproliferative disorders, registered in the EBMT-ProMISe-database were included (n = 232,618) (COD-2 study). Results were compared to those in the ALL/AML/CML COD-1 study. Mortality from bacterial, viral, fungal, and parasitic infections decreased in very early, early and intermediate phases. In the late phase, mortality from bacterial infections increased, while mortality from fungal, viral, or unknown infectious etiology did not change. This pattern was similar for allo- and auto-HCT in COD-1 and COD-2 studies, with a distinct and constant lower incidence of all types of infections at all phases, after auto-HCT. In conclusion, infections were the main cause of death before day +100, followed by relapse. Mortality from infectious deaths significantly decreased, except late phase. Post-transplant mortality has significantly decreased in all phases, from all causes after auto-HCT; it has decreased in all phases after allo-HCT except late phase.

AB - We previously analyzed trends in incidence and factors associated with lethal complications in ALL/AML/CML patients (causes of deaths; COD-1 study). The objective of this study was the analysis of incidence and specific causes of death after HCT, with focus on infectious deaths in two time periods, 1980-2001 (cohort-1) and 2002-2015 (cohort-2). All patients with HCT for lymphoma, plasma cell disorders, chronic leukemia (except CML), myelodysplastic/myeloproliferative disorders, registered in the EBMT-ProMISe-database were included (n = 232,618) (COD-2 study). Results were compared to those in the ALL/AML/CML COD-1 study. Mortality from bacterial, viral, fungal, and parasitic infections decreased in very early, early and intermediate phases. In the late phase, mortality from bacterial infections increased, while mortality from fungal, viral, or unknown infectious etiology did not change. This pattern was similar for allo- and auto-HCT in COD-1 and COD-2 studies, with a distinct and constant lower incidence of all types of infections at all phases, after auto-HCT. In conclusion, infections were the main cause of death before day +100, followed by relapse. Mortality from infectious deaths significantly decreased, except late phase. Post-transplant mortality has significantly decreased in all phases, from all causes after auto-HCT; it has decreased in all phases after allo-HCT except late phase.

KW - Humans

KW - Cause of Death

KW - Hematopoietic Stem Cell Transplantation/methods

KW - Communicable Diseases/etiology

KW - Lymphoma

KW - Chronic Disease

KW - Leukemia, Myeloid, Acute/etiology

KW - Retrospective Studies

U2 - 10.1038/s41409-023-01998-2

DO - 10.1038/s41409-023-01998-2

M3 - SCORING: Journal article

C2 - 37149673

VL - 58

SP - 881

EP - 892

JO - BONE MARROW TRANSPL

JF - BONE MARROW TRANSPL

SN - 0268-3369

IS - 8

ER -