Decrease of lethal infectious complications in the context of causes of death (COD) after hematopoietic cell transplantation: COD-2 and COD-1 study of the Infectious Diseases Working Party EBMT
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Decrease of lethal infectious complications in the context of causes of death (COD) after hematopoietic cell transplantation: COD-2 and COD-1 study of the Infectious Diseases Working Party EBMT. / Styczynski, Jan; Tridello, Gloria; Koster, Linda; Knelange, Nina; Wendel, Lotus; van Biezen, Anja; van der Werf, Steffie; Mikulska, Malgorzata; Gil, Lidia; Cordonnier, Catherine; Ljungman, Per; Averbuch, Diana; Cesaro, Simone; Baldomero, Helen; Chabannon, Christian; Corbacioglu, Selim; Dolstra, Harry; Glass, Bertram; Greco, Raffaella; Kröger, Nicolaus; de Latour, Régis Peffault; Mohty, Mohamad; Neven, Benedicte; Peric, Zinaida; Snowden, John A; Sureda, Anna; Yakoub-Agha, Ibrahim; de la Camara, Rafael.
in: BONE MARROW TRANSPL, Jahrgang 58, Nr. 8, 08.2023, S. 881-892.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Decrease of lethal infectious complications in the context of causes of death (COD) after hematopoietic cell transplantation: COD-2 and COD-1 study of the Infectious Diseases Working Party EBMT
AU - Styczynski, Jan
AU - Tridello, Gloria
AU - Koster, Linda
AU - Knelange, Nina
AU - Wendel, Lotus
AU - van Biezen, Anja
AU - van der Werf, Steffie
AU - Mikulska, Malgorzata
AU - Gil, Lidia
AU - Cordonnier, Catherine
AU - Ljungman, Per
AU - Averbuch, Diana
AU - Cesaro, Simone
AU - Baldomero, Helen
AU - Chabannon, Christian
AU - Corbacioglu, Selim
AU - Dolstra, Harry
AU - Glass, Bertram
AU - Greco, Raffaella
AU - Kröger, Nicolaus
AU - de Latour, Régis Peffault
AU - Mohty, Mohamad
AU - Neven, Benedicte
AU - Peric, Zinaida
AU - Snowden, John A
AU - Sureda, Anna
AU - Yakoub-Agha, Ibrahim
AU - de la Camara, Rafael
N1 - © 2023. The Author(s), under exclusive licence to Springer Nature Limited.
PY - 2023/8
Y1 - 2023/8
N2 - We previously analyzed trends in incidence and factors associated with lethal complications in ALL/AML/CML patients (causes of deaths; COD-1 study). The objective of this study was the analysis of incidence and specific causes of death after HCT, with focus on infectious deaths in two time periods, 1980-2001 (cohort-1) and 2002-2015 (cohort-2). All patients with HCT for lymphoma, plasma cell disorders, chronic leukemia (except CML), myelodysplastic/myeloproliferative disorders, registered in the EBMT-ProMISe-database were included (n = 232,618) (COD-2 study). Results were compared to those in the ALL/AML/CML COD-1 study. Mortality from bacterial, viral, fungal, and parasitic infections decreased in very early, early and intermediate phases. In the late phase, mortality from bacterial infections increased, while mortality from fungal, viral, or unknown infectious etiology did not change. This pattern was similar for allo- and auto-HCT in COD-1 and COD-2 studies, with a distinct and constant lower incidence of all types of infections at all phases, after auto-HCT. In conclusion, infections were the main cause of death before day +100, followed by relapse. Mortality from infectious deaths significantly decreased, except late phase. Post-transplant mortality has significantly decreased in all phases, from all causes after auto-HCT; it has decreased in all phases after allo-HCT except late phase.
AB - We previously analyzed trends in incidence and factors associated with lethal complications in ALL/AML/CML patients (causes of deaths; COD-1 study). The objective of this study was the analysis of incidence and specific causes of death after HCT, with focus on infectious deaths in two time periods, 1980-2001 (cohort-1) and 2002-2015 (cohort-2). All patients with HCT for lymphoma, plasma cell disorders, chronic leukemia (except CML), myelodysplastic/myeloproliferative disorders, registered in the EBMT-ProMISe-database were included (n = 232,618) (COD-2 study). Results were compared to those in the ALL/AML/CML COD-1 study. Mortality from bacterial, viral, fungal, and parasitic infections decreased in very early, early and intermediate phases. In the late phase, mortality from bacterial infections increased, while mortality from fungal, viral, or unknown infectious etiology did not change. This pattern was similar for allo- and auto-HCT in COD-1 and COD-2 studies, with a distinct and constant lower incidence of all types of infections at all phases, after auto-HCT. In conclusion, infections were the main cause of death before day +100, followed by relapse. Mortality from infectious deaths significantly decreased, except late phase. Post-transplant mortality has significantly decreased in all phases, from all causes after auto-HCT; it has decreased in all phases after allo-HCT except late phase.
KW - Humans
KW - Cause of Death
KW - Hematopoietic Stem Cell Transplantation/methods
KW - Communicable Diseases/etiology
KW - Lymphoma
KW - Chronic Disease
KW - Leukemia, Myeloid, Acute/etiology
KW - Retrospective Studies
U2 - 10.1038/s41409-023-01998-2
DO - 10.1038/s41409-023-01998-2
M3 - SCORING: Journal article
C2 - 37149673
VL - 58
SP - 881
EP - 892
JO - BONE MARROW TRANSPL
JF - BONE MARROW TRANSPL
SN - 0268-3369
IS - 8
ER -