Decrease in adhesion molecules on polymorphonuclear leukocytes of patients with fibromyalgia.
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Decrease in adhesion molecules on polymorphonuclear leukocytes of patients with fibromyalgia. / Kaufmann, Ines; Schelling, Gustav; Eisner, Christoph; Richter, Hans Peter; Beyer, Antje; Krauseneck, Till; Chouker, Alexander; Thiel, Manfred.
In: RHEUMATOL INT, Vol. 29, No. 9, 9, 2009, p. 1109-1111.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Decrease in adhesion molecules on polymorphonuclear leukocytes of patients with fibromyalgia.
AU - Kaufmann, Ines
AU - Schelling, Gustav
AU - Eisner, Christoph
AU - Richter, Hans Peter
AU - Beyer, Antje
AU - Krauseneck, Till
AU - Chouker, Alexander
AU - Thiel, Manfred
PY - 2009
Y1 - 2009
N2 - Fibromyalgia (FM) is a chronic widespread pain condition in highly stressed humans. Because stress is known to modulate adhesion molecule expression, we determined L: -selectin (CD62L) and beta(2)-integrin (CD11b/CD18) expression on the surface of polymorphonuclear leukocytes in 22 patients with FM. As compared to age and sex-matched healthy controls, FM patients showed a significantly decreased expression of CD62L (p <0.01) and CD11b/CD18 (p <0.05) on polymorphonuclear leukocytes. These changes might lower the rate of polymorphonuclear leukocyte migration to sites of inflammation and thereby compromise defense against infections and pain control.
AB - Fibromyalgia (FM) is a chronic widespread pain condition in highly stressed humans. Because stress is known to modulate adhesion molecule expression, we determined L: -selectin (CD62L) and beta(2)-integrin (CD11b/CD18) expression on the surface of polymorphonuclear leukocytes in 22 patients with FM. As compared to age and sex-matched healthy controls, FM patients showed a significantly decreased expression of CD62L (p <0.01) and CD11b/CD18 (p <0.05) on polymorphonuclear leukocytes. These changes might lower the rate of polymorphonuclear leukocyte migration to sites of inflammation and thereby compromise defense against infections and pain control.
M3 - SCORING: Zeitschriftenaufsatz
VL - 29
SP - 1109
EP - 1111
JO - RHEUMATOL INT
JF - RHEUMATOL INT
SN - 0172-8172
IS - 9
M1 - 9
ER -