Death begets a new beginning
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Death begets a new beginning. / Bosurgi, Lidia; Hughes, Lindsey D; Rothlin, Carla V; Ghosh, Sourav.
In: IMMUNOL REV, Vol. 280, No. 1, 11.2017, p. 8-25.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Death begets a new beginning
AU - Bosurgi, Lidia
AU - Hughes, Lindsey D
AU - Rothlin, Carla V
AU - Ghosh, Sourav
N1 - © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
PY - 2017/11
Y1 - 2017/11
N2 - Cell death is a perpetual feature of tissue microenvironments; each day under homeostatic conditions, billions of cells die and must be swiftly cleared by phagocytes. However, cell death is not limited to this natural turnover-apoptotic cell death can be induced by infection, inflammation, or severe tissue injury. Phagocytosis of apoptotic cells is thus coupled to specific functions, from the induction of growth factors that can stimulate the replacement of dead cells to the promotion of tissue repair or tissue remodeling in the affected site. In this review, we outline the mechanisms by which phagocytes sense apoptotic cell death and discuss how phagocytosis is integrated with environmental cues to drive appropriate responses.
AB - Cell death is a perpetual feature of tissue microenvironments; each day under homeostatic conditions, billions of cells die and must be swiftly cleared by phagocytes. However, cell death is not limited to this natural turnover-apoptotic cell death can be induced by infection, inflammation, or severe tissue injury. Phagocytosis of apoptotic cells is thus coupled to specific functions, from the induction of growth factors that can stimulate the replacement of dead cells to the promotion of tissue repair or tissue remodeling in the affected site. In this review, we outline the mechanisms by which phagocytes sense apoptotic cell death and discuss how phagocytosis is integrated with environmental cues to drive appropriate responses.
KW - Journal Article
KW - Review
U2 - 10.1111/imr.12585
DO - 10.1111/imr.12585
M3 - SCORING: Review article
C2 - 29027219
VL - 280
SP - 8
EP - 25
JO - IMMUNOL REV
JF - IMMUNOL REV
SN - 0105-2896
IS - 1
ER -